Erick Giang
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View article: The conserved bridging domain on HCV E1E2 glycoprotein complex is targeted by neutralizing antibodies from diverse lineages
The conserved bridging domain on HCV E1E2 glycoprotein complex is targeted by neutralizing antibodies from diverse lineages Open
The induction of potent and cross-reactive neutralizing antibody (nAb) responses remains a challenge in vaccine development against antigenically diverse viruses such as hepatitis C virus (HCV). The HCV E1E2 glycoprotein complex contains t…
View article: In Vivo Determinants of Hepatitis C Virus Adaptation and Escape From Neutralizing Antibody AR5A
In Vivo Determinants of Hepatitis C Virus Adaptation and Escape From Neutralizing Antibody AR5A Open
We show that L665S is an AR5A escape mutation in vivo, supporting the use of cost-effective vaccine escape studies in vitro. We also identify novel in vivo adaptive mutations and characterize their mechanism of action, thus facilitating in…
View article: Structural and genetic signatures of two classes of HCV E2 neutralizing face antibodies from non-human primates immunized with a recombinant E1E2
Structural and genetic signatures of two classes of HCV E2 neutralizing face antibodies from non-human primates immunized with a recombinant E1E2 Open
Hepatitis C continues to be a significant public health problem despite advancements in antiviral therapeutics. To eliminate this disease, an effective vaccine against new infections and re-infections is needed. However, to date only one H…
View article: Antigenic and EM characterization of the Chiron experimental hepatitis C virus vaccine
Antigenic and EM characterization of the Chiron experimental hepatitis C virus vaccine Open
The Chiron experimental HCV vaccine, the only envelope-based HCV vaccine candidate to date, was immunogenic and safe in a phase 1 trial, though its efficacy remains untested. This study examined the antigenic properties of the vaccine anti…
View article: Native-like soluble E1E2 glycoprotein heterodimers on self-assembling protein nanoparticles for hepatitis C virus vaccine design
Native-like soluble E1E2 glycoprotein heterodimers on self-assembling protein nanoparticles for hepatitis C virus vaccine design Open
Hepatitis C virus (HCV) is a leading cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma worldwide. E1E2-based HCV vaccine development has been hindered by the challenge of producing a soluble E1E2 (sE1E2) antigen that …
View article: Virus reactivation in a non-cirrhotic HBV patient requiring liver transplantation after cessation of nucleoside analogue therapy
Virus reactivation in a non-cirrhotic HBV patient requiring liver transplantation after cessation of nucleoside analogue therapy Open
Nucleos(t)ide analogues (NAs) are a mainstay of therapy for chronic hepatitis B (CHB) infections and have a profound effect on hepatitis B virus (HBV) suppression. We report a rare case of HBV reactivation in a CHB patient without cirrhosi…
View article: Evaluation of a Series of Lipidated Tucaresol Adjuvants in a Hepatitis C Virus Vaccine Model
Evaluation of a Series of Lipidated Tucaresol Adjuvants in a Hepatitis C Virus Vaccine Model Open
Hepatitis C virus (HCV) infections represent a global health challenge; however, developing a vaccine for treatment of HCV infection has remained difficult as heterogeneous HCV contains distinct genotypes, and each genotype contains variou…
View article: An alternate conformation of HCV E2 neutralizing face as an additional vaccine target
An alternate conformation of HCV E2 neutralizing face as an additional vaccine target Open
An alternate conformation is found for the major antibody target on hepatitis C virus to aid in rational vaccine design.
View article: Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines
Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines Open
An HCV vaccine strategy displays optimized E2 cores on nanoparticles for eliciting a cross-neutralizing B cell response.
View article: Rational design of hepatitis C virus E2 core nanoparticle vaccines
Rational design of hepatitis C virus E2 core nanoparticle vaccines Open
Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 are critical for cell entry with E2 being the major target of neutralizing antibodies (NAbs). Here, we present a comprehensive strategy for B cell-based HCV vaccine development throu…
View article: Genetic and structural insights into broad neutralization of hepatitis C virus by human V <sub>H</sub> 1-69 antibodies
Genetic and structural insights into broad neutralization of hepatitis C virus by human V <sub>H</sub> 1-69 antibodies Open
We elucidate the role of human V H 1-69 antibodies in broad neutralization of HCV to facilitate rational vaccine design.
View article: Interrogation of Antigen Display on Individual Vaccine Nanoparticles for Achieving Neutralizing Antibody Responses against Hepatitis C Virus
Interrogation of Antigen Display on Individual Vaccine Nanoparticles for Achieving Neutralizing Antibody Responses against Hepatitis C Virus Open
Elicitation of neutralizing antibody responses against hepatitis C virus (HCV) has been a challenging goal. While the E2 subunit of the HCV envelope glycoprotein complex is a promising target for generating cross-genotype neutralizing anti…
View article: Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis
Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis Open
The hepatitis C virus (HCV) envelope glycoproteins E1 and E2 form a non-covalently linked heterodimer on the viral surface that mediates viral entry. E1, E2 and the heterodimer complex E1E2 are candidate vaccine antigens, but are technical…
View article: Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 Trimers
Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 Trimers Open
Broadly neutralizing antibodies (bNAbs) have provided valuable insights into the humoral immune response to HIV-1. While rationally designed epitope scaffolds and well-folded gp140 trimers have been proposed as vaccine antigens, a comparat…
View article: Structural flexibility at a major conserved antibody target on hepatitis C virus E2 antigen
Structural flexibility at a major conserved antibody target on hepatitis C virus E2 antigen Open
Significance Hepatitis C virus is an important human pathogen, and its E2 envelope glycoprotein is the major target of neutralizing antibodies (NAbs) and, hence, a promising vaccine candidate. Many broadly NAbs (bNAbs) to E2 recognize the …