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View article: RNA dysfunction in age-related macular degeneration: the role of U1 snRNP complex and neurodegenerative diseases
RNA dysfunction in age-related macular degeneration: the role of U1 snRNP complex and neurodegenerative diseases Open
View article: Cecal Slurry-Induced Sepsis in Mice Impairs Cognition and Decreases Sumo-2/3 Conjugation
Cecal Slurry-Induced Sepsis in Mice Impairs Cognition and Decreases Sumo-2/3 Conjugation Open
View article: Effects of the therapeutic correction of U1 snRNP complex on Alzheimer’s disease
Effects of the therapeutic correction of U1 snRNP complex on Alzheimer’s disease Open
The U1 snRNP complex recognizes pre-mRNA splicing sites in the early stages of spliceosome assembly and suppresses premature cleavage and polyadenylation. Its dysfunction may precede Alzheimer’s disease (AD) hallmarks. Here we evaluated th…
View article: Effect of the therapeutic modulation of APT20TTMG on U1 snRNP complex assembly in Alzheimer’s disease
Effect of the therapeutic modulation of APT20TTMG on U1 snRNP complex assembly in Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is the most common cause of dementia worldwide. It is characterized by dysfunction in the U1 small nuclear ribonucleoproteins (snRNPs) complex, which may precede TAU aggregation, enhancing premature poly…
View article: SUMOylation modulates mitochondrial dynamics in an in vitro rotenone model of Parkinson's disease
SUMOylation modulates mitochondrial dynamics in an in vitro rotenone model of Parkinson's disease Open
SUMOylation is a post-translational modification essential for various biological processes. SUMO proteins bind to target substrates in a three-step enzymatic pathway, which is rapidly reversible by the action of specific proteases, known …
View article: Circadian rhythm alterations affecting the pathology of neurodegenerative diseases
Circadian rhythm alterations affecting the pathology of neurodegenerative diseases Open
The circadian rhythm is a nearly 24‐h oscillation found in various physiological processes in the human brain and body that is regulated by environmental and genetic factors. It is responsible for maintaining body homeostasis and it is cri…
View article: Grupos antitabagismo em Balneário Camboriú (Santa Catarina, Brasil): fatores preditivos de cessação a curto e a longo prazo
Grupos antitabagismo em Balneário Camboriú (Santa Catarina, Brasil): fatores preditivos de cessação a curto e a longo prazo Open
Introdução: O tabagismo é responsável por milhões de mortes anualmente e é um fator de risco para diversas doenças crônicas não transmissíveis, com significante impacto socioeconômico no mundo inteiro. No Brasil, o atendimento aos paciente…
View article: SUMO-modifying Huntington’s disease
SUMO-modifying Huntington’s disease Open
View article: Effects of amyloid-β on protein SUMOylation and levels of mitochondrial proteins in primary cortical neurons
Effects of amyloid-β on protein SUMOylation and levels of mitochondrial proteins in primary cortical neurons Open
View article: Participação dos receptores hipocampais do neuropeptídeo Y na modulação da memória avaliada no labirinto aquático
Participação dos receptores hipocampais do neuropeptídeo Y na modulação da memória avaliada no labirinto aquático Open
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2019.
View article: Towards Therapeutic Alternatives for Mercury Neurotoxicity in the Amazon: Unraveling the Pre-Clinical Effects of the Superfruit Açaí (Euterpe oleracea, Mart.) as Juice for Human Consumption
Towards Therapeutic Alternatives for Mercury Neurotoxicity in the Amazon: Unraveling the Pre-Clinical Effects of the Superfruit Açaí (Euterpe oleracea, Mart.) as Juice for Human Consumption Open
Methylmercury (MeHg) exposure is a serious problem of public health, especially in the Amazon. Exposure in riverine populations is responsible for neurobehavioral abnormalities. It was hypothesized that consumption of Amazonian fruits coul…