Erik C. Hett
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View article: Correction: The dark matter in cancer immunology: beyond the visible– unveiling multiomics pathways to breakthrough therapies
Correction: The dark matter in cancer immunology: beyond the visible– unveiling multiomics pathways to breakthrough therapies Open
View article: Nanocarriers for cutting-edge cancer immunotherapies
Nanocarriers for cutting-edge cancer immunotherapies Open
Cancer immunotherapy aims to harness the body's own immune system for effective and long-lasting elimination of malignant neoplastic tissues. Owing to the advance in understanding of cancer pathology and immunology, many novel strategies f…
View article: 1403-B Sonata’s proprietary intrinsic antigen release technology (iART) drives in situ generation of potent anti-tumor immunity across warm and cold tumor models
1403-B Sonata’s proprietary intrinsic antigen release technology (iART) drives in situ generation of potent anti-tumor immunity across warm and cold tumor models Open
Background Despite considerable progress in immunotherapy, the challenge persists in effectively targeting immunologically 'cold' tumors. Cytokine-driven therapy has exhibited promise; however, its integration into clinical practice has be…
View article: 1387 SNT-20109 induces protective immunity in the murine syngeneic tumor cell line, CT26: a dual approach of direct cytotoxicity and defined immune activation
1387 SNT-20109 induces protective immunity in the murine syngeneic tumor cell line, CT26: a dual approach of direct cytotoxicity and defined immune activation Open
Background Despite considerable advances in cancer immunotherapy, it has proven difficult to effectively target 'cold' tumors with limited immune infiltration. Chimeric antigen receptor T cells (CAR-T cells) are one potential solution; how…
View article: High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface
High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface Open
View article: A high‐throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell‐based assays
A high‐throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell‐based assays Open
Cyclic peptides are poised to target historically difficult to drug intracellular protein–protein interactions, however, their general cell impermeability poses a challenge for characterizing function. Recent advances in microfluidics have…
View article: Immunogenic cell death in cancer: concept and therapeutic implications
Immunogenic cell death in cancer: concept and therapeutic implications Open
View article: High resolution photocatalytic mapping of SARS-CoV-2 Spike protein-host cell membrane interactions
High resolution photocatalytic mapping of SARS-CoV-2 Spike protein-host cell membrane interactions Open
Identifying protein environments at the virus-host cell interface can improve our understanding of viral entry and pathogenesis. SARS-CoV-2, the virus behind the ongoing COVID-19 pandemic, uses the cell surface ACE2 protein as a major rece…
View article: Follicular T cells optimize the germinal center response to SARS-CoV-2 protein vaccination in mice
Follicular T cells optimize the germinal center response to SARS-CoV-2 protein vaccination in mice Open
Follicular helper T (Tfh) cells promote, whereas follicular regulatory T (Tfr) cells restrain, germinal center (GC) reactions. However, the precise roles of these cells in the complex GC reaction remain poorly understood. Here, we perturb …
View article: Detection of Cell-Cell Interactions via Photocatalytic Cell Tagging
Detection of Cell-Cell Interactions via Photocatalytic Cell Tagging Open
Cell-cell interactions drive essential biological processes critical to cell and tissue development, function, pathology, and disease outcome. The growing appreciation of immune cell interactions within disease environments has led to sign…
View article: The chemical biology of coronavirus host–cell interactions
The chemical biology of coronavirus host–cell interactions Open
Chemical biology strategies can play important roles in studying the complexity of SARS-CoV-2–host interactions at molecular level detail.
View article: Design of a Multiuse Photoreactor To Enable Visible‐Light Photocatalytic Chemical Transformations and Labeling in Live Cells
Design of a Multiuse Photoreactor To Enable Visible‐Light Photocatalytic Chemical Transformations and Labeling in Live Cells Open
Despite the growing use of visible‐light photochemistry in both chemistry and biology, no general low‐heat photoreactor for use across these different disciplines exists. Herein, we describe the design and use of a standardized photoreacto…
View article: Design of a Multi-Use Photoreactor to Enable Visible Light Photocatalytic Chemical Transformations and Labeling in Live Cells
Design of a Multi-Use Photoreactor to Enable Visible Light Photocatalytic Chemical Transformations and Labeling in Live Cells Open
Despite the growing utilization of visible light photochemistry in both chemistry and biology, a general low-heat photoreactor for use across these different disciplines does not exist. Herein, we describe the design and utilization of a s…
View article: Design of a Multi-Use Photoreactor to Enable Visible Light Photocatalytic Chemical Transformations and Labeling in Live Cells
Design of a Multi-Use Photoreactor to Enable Visible Light Photocatalytic Chemical Transformations and Labeling in Live Cells Open
Despite the growing utilization of visible light photochemistry in both chemistry and biology, a general low-heat photoreactor for use across these different disciplines does not exist. Herein, we describe the design and utilization of a s…
View article: Colorectal cancer-associated anaerobic bacteria proliferate in tumor spheroids and alter the microenvironment
Colorectal cancer-associated anaerobic bacteria proliferate in tumor spheroids and alter the microenvironment Open
Recent reports show that colorectal tumors contain microbiota that are distinct from those that reside in a ‘normal’ colon environment, and that these microbiota can contribute to cancer progression. Fusobacterium nucleatum is the most com…
View article: Microenvironment mapping via Dexter energy transfer on immune cells
Microenvironment mapping via Dexter energy transfer on immune cells Open
Pinpointing proteins To develop drugs that target a specific cell surface protein, it's helpful to know which other proteins reside in its vicinity. Geri et al. report a light-triggered labeling technique that improves the spatial resoluti…
View article: Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition
Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition Open
PF-06651600, a newly discovered potent JAK3-selective inhibitor, is highly efficacious at inhibiting γc cytokine signaling, which is dependent on both JAK1 and JAK3. PF-06651600 allowed the comparison of JAK3-selective inhibition to pan-JA…