Erik Hasenoehrl
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View article: Outcomes of Hospitalized Patients with Moderate to Severe UC from 1996 to 2021 in a Large Healthcare System in the US
Outcomes of Hospitalized Patients with Moderate to Severe UC from 1996 to 2021 in a Large Healthcare System in the US Open
View article: An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis
An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis Open
View article: Bioenergetic Inhibitors: Antibiotic Efficacy and Mechanisms of Action in Mycobacterium tuberculosis
Bioenergetic Inhibitors: Antibiotic Efficacy and Mechanisms of Action in Mycobacterium tuberculosis Open
Development of novel anti-tuberculosis combination regimens that increase efficacy and reduce treatment timelines will improve patient compliance, limit side-effects, reduce costs, and enhance cure rates. Such advancements would significan…
View article: Dual inhibition of the terminal oxidases eradicates antibiotic‐tolerant <i>Mycobacterium tuberculosis</i>
Dual inhibition of the terminal oxidases eradicates antibiotic‐tolerant <i>Mycobacterium tuberculosis</i> Open
View article: Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection
Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection Open
A major constraint for developing new anti-tuberculosis drugs is the limited number of validated targets that allow eradication of persistent infections. Here, we uncover a vulnerable component of Mycobacterium tuberculosis (Mtb) persisten…
View article: Inhibitors of energy metabolism interfere with antibiotic-induced death in mycobacteria
Inhibitors of energy metabolism interfere with antibiotic-induced death in mycobacteria Open
View article: Exploiting the synthetic lethality between terminal respiratory oxidases to kill <i>Mycobacterium tuberculosis</i> and clear host infection
Exploiting the synthetic lethality between terminal respiratory oxidases to kill <i>Mycobacterium tuberculosis</i> and clear host infection Open
Significance New drugs are needed to combat multidrug-resistant tuberculosis. The electron transport chain (ETC) maintains the electrochemical potential across the cytoplasmic membrane and allows production of ATP, the energy currency of a…
View article: Oxidative Phosphorylation as a Target Space for Tuberculosis: Success, Caution, and Future Directions
Oxidative Phosphorylation as a Target Space for Tuberculosis: Success, Caution, and Future Directions Open
The emergence and spread of drug-resistant pathogens, and our inability to develop new antimicrobials to combat resistance, have inspired scientists to seek out new targets for drug development. The Mycobacterium tuberculosis complex is a …