Erik Henke
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View article: Assessing the Influence of Feedback Strategies on Errors in Crowdsourced Annotation of Tumor Images
Assessing the Influence of Feedback Strategies on Errors in Crowdsourced Annotation of Tumor Images Open
Crowdsourcing enables the acquisition of distributed human intelligence for solving tasks involving human judgments in scalable ways, with many use cases in various application areas accessing human intelligence. However, crowdworkers comp…
View article: A humanized breast cancer microorganoid platform for the ranked evaluation of tumor microenvironment-targeted drugs by light sheet fluorescence microscopy
A humanized breast cancer microorganoid platform for the ranked evaluation of tumor microenvironment-targeted drugs by light sheet fluorescence microscopy Open
Targeting the supportive tumor microenvironment (TME) is an approach of high interest in cancer drug development. However, assessing TME-targeted drug candidates presents a unique set of challenges: Adequate assays need to recreate the TME…
View article: Normalization of Snai1-mediated vessel dysfunction increases drug response in cancer
Normalization of Snai1-mediated vessel dysfunction increases drug response in cancer Open
Blood vessels in tumors are often dysfunctional. This impairs the delivery of therapeutic agents to and distribution among the cancer cells and subsequently reduces treatment efficacy. The dysfunctional vessel phenotypes are attributed to …
View article: Data from Selective Killing of Tumor Neovasculature Paradoxically Improves Chemotherapy Delivery to Tumors
Data from Selective Killing of Tumor Neovasculature Paradoxically Improves Chemotherapy Delivery to Tumors Open
Antiangiogenic therapies are frequently used with concomitantly administered cancer chemotherapy to improve outcomes, but the mechanism for the benefit of the combination is uncertain. We describe a mechanism by which a specific, cytotoxic…
View article: Data from Selective Killing of Tumor Neovasculature Paradoxically Improves Chemotherapy Delivery to Tumors
Data from Selective Killing of Tumor Neovasculature Paradoxically Improves Chemotherapy Delivery to Tumors Open
Antiangiogenic therapies are frequently used with concomitantly administered cancer chemotherapy to improve outcomes, but the mechanism for the benefit of the combination is uncertain. We describe a mechanism by which a specific, cytotoxic…
View article: Supplementary Methods, Figures 1-3 from Selective Killing of Tumor Neovasculature Paradoxically Improves Chemotherapy Delivery to Tumors
Supplementary Methods, Figures 1-3 from Selective Killing of Tumor Neovasculature Paradoxically Improves Chemotherapy Delivery to Tumors Open
Supplementary Methods, Figures 1-3 from Selective Killing of Tumor Neovasculature Paradoxically Improves Chemotherapy Delivery to Tumors
View article: Supplementary Methods, Figures 1-3 from Selective Killing of Tumor Neovasculature Paradoxically Improves Chemotherapy Delivery to Tumors
Supplementary Methods, Figures 1-3 from Selective Killing of Tumor Neovasculature Paradoxically Improves Chemotherapy Delivery to Tumors Open
Supplementary Methods, Figures 1-3 from Selective Killing of Tumor Neovasculature Paradoxically Improves Chemotherapy Delivery to Tumors
View article: Imaged-based modeling of vascular organization to evaluate anti-angiogenic therapy
Imaged-based modeling of vascular organization to evaluate anti-angiogenic therapy Open
In tumor therapy anti-angiogenic approaches have the potential to increase the efficacy of a wide variety of subsequently or co-administered agents, possibly by improving or normalizing the defective tumor vasculature. Successful implement…
View article: Taxanes act as vascular disrupting agents and increase rate of metastasis when combined with anti-angiogenic therapy
Taxanes act as vascular disrupting agents and increase rate of metastasis when combined with anti-angiogenic therapy Open
Taxanes are known to have a profound effect on endothelial cells and the vasculature even at low doses. Here, we show that taxanes, rather than being anti-angiogenic, function more as vascular disrupting agents (VDAs), although they exert …
View article: U1 snRNP suppresses microRNA biogenesis by alternative intronic polyadenylation in melanoma
U1 snRNP suppresses microRNA biogenesis by alternative intronic polyadenylation in melanoma Open
Activation of intronic polyadenylation signals results in premature cleavage and polyadenylation (PCPA). The majority of mammalian miRNAs are also located within intronic regions of protein-coding genes and are transcriptionally co-express…
View article: Fibrin and Extracellular Matrix: Scaffolds and Network for Malignant Cells
Fibrin and Extracellular Matrix: Scaffolds and Network for Malignant Cells Open
Malignant cells build up a protective shield in form of a fibrin meshwork surrounding the tumor which helps it to escape the body’s immune system. In addition, tumor and stromal cells provide with an abundant extracellular matrix (ECM) con…
View article: Halting the vicious cycle within the multiple myeloma ecosystem: blocking JAM-A on bone marrow endothelial cells restores angiogenic homeostasis and suppresses tumor progression
Halting the vicious cycle within the multiple myeloma ecosystem: blocking JAM-A on bone marrow endothelial cells restores angiogenic homeostasis and suppresses tumor progression Open
Interactions of malignant multiple myeloma (MM) plasma cells (MM-cells) with the microenvironment control MM-cell growth, survival, drug-resistance and dissemination. As in MM microvascular density increases in the bone marrow (BM), we inv…
View article: Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy
Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy Open
Solid tumors are complex organ-like structures that consist not only of tumor cells but also of vasculature, extracellular matrix (ECM), stromal, and immune cells. Often, this tumor microenvironment (TME) comprises the larger part of the o…
View article: Generation of complex human organoid models including vascular networks by incorporation of mesodermal progenitor cells
Generation of complex human organoid models including vascular networks by incorporation of mesodermal progenitor cells Open
View article: The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells
The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells Open
Pluripotent stem cells give rise to reproductively enabled offsprings by generating progressively lineage-restricted multipotent stem cells that would differentiate into lineage-committed stem and progenitor cells. These lineage-committed …
View article: Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice
Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice Open
Maintenance of tumor vasculature integrity is indispensable for tumor growth and thus affects tumor progression. Previous studies have identified platelets as major regulators of tumor vascular integrity, as their depletion selectively ren…
View article: LOX-catalyzed collagen stabilization is a proximal cause for intrinsic resistance to chemotherapy
LOX-catalyzed collagen stabilization is a proximal cause for intrinsic resistance to chemotherapy Open
View article: VEGF-ablation therapy reduces drug delivery and therapeutic response in ECM-dense tumors
VEGF-ablation therapy reduces drug delivery and therapeutic response in ECM-dense tumors Open
The inadequate transport of drugs into the tumor tissue caused by its abnormal vasculature is a major obstacle to the treatment of cancer. Anti-vascular endothelial growth factor (anti-VEGF) drugs can cause phenotypic alteration and matura…
View article: Inhibition of Lysyl Oxidases Improves Drug Diffusion and Increases Efficacy of Cytotoxic Treatment in 3D Tumor Models
Inhibition of Lysyl Oxidases Improves Drug Diffusion and Increases Efficacy of Cytotoxic Treatment in 3D Tumor Models Open
Tumors are characterized by a rigid, highly cross-linked extracellular matrix (ECM), which impedes homogeneous drug distribution and potentially protects malignant cells from exposure to therapeutics. Lysyl oxidases are major contributors …
View article: Centralizers of normal subgroups and the<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.gif" overflow="scroll"><mml:msup><mml:mrow><mml:mi>Z</mml:mi></mml:mrow><mml:mrow><mml:mo>⁎</mml:mo></mml:mrow></mml:msup></mml:math>-theorem
Centralizers of normal subgroups and the-theorem Open
View article: Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer
Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer Open