Erik J. Sorensen
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View article: Nanoscale Precise Stamping of Biomolecule Patterns Using DNA Origami
Nanoscale Precise Stamping of Biomolecule Patterns Using DNA Origami Open
Understanding the importance of ligand patterning in biological processes requires precise control over molecular positioning and spacing. While DNA origami structures offer nanoscale precision in biomolecule arrangement, their biological …
View article: Nanoscale precise stamping of biomolecule patterns using DNA origami
Nanoscale precise stamping of biomolecule patterns using DNA origami Open
Understanding the importance of ligand patterning in biological processes requires precise control over molecular positioning and spacing. While DNA origami structures offer nanoscale precision in biomolecule arrangement, their biological …
View article: Hirocidins, Cytotoxic Metabolites from <i>Streptomyces hiroshimensis</i>, Induce Mitochondrion‐Mediated Apoptosis
Hirocidins, Cytotoxic Metabolites from <i>Streptomyces hiroshimensis</i>, Induce Mitochondrion‐Mediated Apoptosis Open
Recent advances in whole genome sequencing have revealed an immense microbial potential for the production of therapeutic small molecules, even from well‐known producers. To access this potential, we subjected prominent antimicrobial produ…
View article: Nitrogen-to-Carbon Single Atom Point Mutation of Pyridine N-Oxides
Nitrogen-to-Carbon Single Atom Point Mutation of Pyridine N-Oxides Open
Single-atom editing has emerged as a powerful process for altering molecular structures with precision. Within this growing class of transformations, reactions that replace one atom for another in heterocycles, while desirable, remain limi…
View article: CCDC 2181283: Experimental Crystal Structure Determination
CCDC 2181283: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: A Concise Synthesis of Pleurotin Enabled by a Nontraditional C–H Epimerization
A Concise Synthesis of Pleurotin Enabled by a Nontraditional C–H Epimerization Open
An 8-step synthesis of a known pentacyclic intermediate towards the natural product pleurotin (1) is described. Pleurotin and related benzoquinone natural products are of great interest for their powerful anticancer and antibiotic activiti…
View article: A Concise Synthesis of Pleurotin Enabled by a Nontraditional C–H Epimerization
A Concise Synthesis of Pleurotin Enabled by a Nontraditional C–H Epimerization Open
An 8-step synthesis of a known pentacyclic intermediate towards the natural product pleurotin (1) is described. Pleurotin and related benzoquinone natural products are of great interest for their powerful anticancer and antibiotic activiti…
View article: Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp3)‒H Arylation with a Transient Directing Group
Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp3)‒H Arylation with a Transient Directing Group Open
Methylene-selective C‒H functionalization is a significant hurdle that remains to be addressed in the field of Pd(II) cataly-sis. In this paper we report a Pd(II) catalyzed synthesis of benzocyclobutenes by methylene-selective C(sp3)‒H ary…
View article: Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp3)‒H Arylation with a Transient Directing Group
Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp3)‒H Arylation with a Transient Directing Group Open
Methylene-selective C‒H functionalization is a significant hurdle that remains to be addressed in the field of Pd(II) cataly-sis. In this paper we report a Pd(II) catalyzed synthesis of benzocyclobutenes by methylene-selective C(sp3)‒H ary…
View article: Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp3)‒H Arylation with a Transient Directing Group
Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp3)‒H Arylation with a Transient Directing Group Open
Methylene-selective C‒H functionalization is a significant hurdle that remains to be addressed in the field of Pd(II) cataly-sis. In this paper we report a Pd(II) catalyzed synthesis of benzocyclobutenes by methylene-selective C(sp3)‒H ary…
View article: Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp3)‒H Arylation with a Transient Directing Group
Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp3)‒H Arylation with a Transient Directing Group Open
Methylene-selective C‒H functionalization is a significant hurdle that remains to be addressed in the field of Pd(II) cataly-sis. In this paper we report a Pd(II) catalyzed synthesis of benzocyclobutenes by methylene-selective C(sp3)‒H ary…
View article: CCDC 1952011: Experimental Crystal Structure Determination
CCDC 1952011: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1952012: Experimental Crystal Structure Determination
CCDC 1952012: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands
Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands Open
It has been proposed that one of the mechanisms of taxane-site ligand-mediated tubulin activation is modulation of the structure of a switch element (the M-loop) from a disordered form in dimeric tubulin to a folded helical structure in mi…
View article: Ir(<scp>iii</scp>)-catalyzed<i>ortho</i>C–H alkylations of (hetero)aromatic aldehydes using alkyl boron reagents
Ir(<span>iii</span>)-catalyzed<i>ortho</i>C–H alkylations of (hetero)aromatic aldehydes using alkyl boron reagents Open
The direct Ir(iii)-catalyzed ortho C–H alkylations of (hetero)aromatic aldehydes have been accomplished using aniline as the transient ligand and alkyl boron reagents as the coupling partner.
View article: <i>In Vitro</i> Reconstitution of OxyA Enzymatic Activity Clarifies Late Steps in Vancomycin Biosynthesis
<i>In Vitro</i> Reconstitution of OxyA Enzymatic Activity Clarifies Late Steps in Vancomycin Biosynthesis Open
Studies on the biosynthesis of glycopeptide antibiotics have provided many insights into the strategies that Nature employs to build architecturally strained molecules. A key structural feature of vancomycin, the founding member of this cl…
View article: Toward a mild dehydroformylation using base-metal catalysis
Toward a mild dehydroformylation using base-metal catalysis Open
Dehydroformylation, a challenging, underexplored reaction, can be performed under mild conditions using a designed cooperative base metal catalyst system.