Explanipedia

Epitopes targeted by autoantibodies in presymptomatic individuals predict early rheumatoid arthritis Open

Yibo He, Outi Sareila, Linda Johansson, Monica Leu Agelii, Lei Cheng , et al. · 2025

Autoantibodies to joint-related peptides as predictive markers in early rheumatoid arthritis Open

Monica Leu Agelii, Outi Sareila, Erik Lönnblom, Lei Cheng, Kristina Forslind , et al. · 2024

Objective For better management of RA, new biomarkers are needed to predict the development of different disease courses. This study aims to identify autoantibodies against epitopes on proteins in the joints and to predict disease outcome …

Correction: Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice Open

Mike Aoun, Ana Coelho, Alexander Krämer, Amit Saxena, Pierre Sabatier , et al. · 2023

In the originally published article, the figure images for Figs. 4 and S4 were accidentally swapped with Figs. 5 and S5, respectively; the legends remain unchanged.The corrected figures and their legends are shown here.In addition, figure …

A subset of type-II collagen-binding antibodies prevents experimental arthritis by inhibiting FCGR3 signaling in neutrophils Open

Zhongwei Xu, Bingze Xu, Susanna L. Lundström, Àlex Moreno‐Giró, Danxia Zhao , et al. · 2023

Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice Open

Mike Aoun, Ana Coelho, Alexander Krämer, Amit Saxena, Pierre Sabatier , et al. · 2023

B cells undergo several rounds of selection to eliminate potentially pathogenic autoreactive clones, but in contrast to T cells, evidence of positive selection of autoreactive B cells remains moot. Using unique tetramers, we traced natural…

OP0123 AUTOANTIBODIES TO JOINT-RELATED PROTEINS PREDICT REMISSION IN NEW ONSET RA WITH HIGH SPECIFICITY Open

Monica Leu Agelii, Outi Sareila, Erik Lönnblom, Kristina Forslind, Ingiäld Hafström , et al. · 2023

A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis Open

Yibo He, Changrong Ge, Àlex Moreno‐Giró, Bingze Xu, Christian M. Beusch , et al. · 2023

Autoantibodies to <span>Disease‐Related</span> Proteins in Joints as Novel Biomarkers for the Diagnosis of Rheumatoid Arthritis Open

Erik Lönnblom, Monica Leu Agelii, Outi Sareila, Lei Cheng, Bingze Xu , et al. · 2023

Objective This study was undertaken to develop and characterize a multiplex immunoassay for detection of autoantibodies against peptides derived from proteins known to play a role in development of arthritis and that are also expressed in …

Rheumatoid arthritis sera antibodies to citrullinated collagen type II bind to joint cartilage Open

Qixing Li, Yanpeng Li, Bibo Liang, Rui Xu, Bingze Xu , et al. · 2022

Early Increase of Circulating Transitional B Cells and Autoantibodies to <span>Joint‐Related</span> Proteins in Patients With Metastatic Melanoma Developing Checkpoint Inhibitor–Induced Inflammatory Arthritis Open

Mariele Gatto, Sara Bjursten, Charlotte Jonsson, Monica Leu Agelii, Caroline Jonell , et al. · 2022

Objective To investigate potential associations between B cell–related immunologic changes and development of inflammatory arthritis (IA) after treatment with immune checkpoint inhibitors (ICIs). Methods Patients who developed ICI‐induced …

POS0562 AUTOANTIBODIES TO JOINT PROTEINS AS NOVEL BIOMARKERS FOR THE DIAGNOSIS OF UNTREATED EARLY RHEUMATOID ARTHRITIS Open

Erik Lönnblom, Monica Leu Agelii, Outi Sareila, I Hafström, M. Andersson , et al. · 2022

Antibodies to Cartilage Oligomeric Matrix Protein Are Pathogenic in Mice and May Be Clinically Relevant in Rheumatoid Arthritis Open

Changrong Ge, Dongmei Tong, Erik Lönnblom, Bibo Liang, Weiwei Cai , et al. · 2022

Objective Cartilage oligomeric matrix protein (COMP) is an autoantigen in rheumatoid arthritis (RA) and experimental models of arthritis. This study was undertaken to investigate the structure, function, and relevance of anti‐COMP antibodi…

Rheumatoid arthritis chondrocytes produce increased levels of pro-inflammatory proteins Open

Karin Önnheim, Shan Huang, Alexander Strid Holmertz, S. Andersson, Erik Lönnblom , et al. · 2022

Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases Open

Gonzalo Fernandez Lahore, Michael Förster, Martina Johannesson, Pierre Sabatier, Erik Lönnblom , et al. · 2021

Antibodies as pathogenic factors and biomarkers in rheumatoid arthritis Open

Erik Lönnblom · 2021

Ever since the evolution of an adaptive immune system capable of creating immune receptors that may recognize self-antigens, we have been at risk of autoimmunity. There are over 100 different types of autoimmune diseases targeting almost e…

Polymorphic estrogen receptor binding site causes CD2-dependent sex bias in the susceptibility to autoimmune diseases Open

Gonzalo Fernandez Lahore, Michael Förster, Martina Johannesson, Pierre Sabatier, Erik Lönnblom , et al. · 2021

Complex autoimmune diseases are sexually dimorphic. An interplay between predisposing genetics and sex-related factors likely determines the sex discrepancy in the immune response, but conclusive evidence is lacking regarding the underlyin…

Natural polymorphism of Ym1 regulates pneumonitis through alternative activation of macrophages Open

Wenhua Zhu, Erik Lönnblom, Michael Förster, Martina Johannesson, Pei Tao , et al. · 2020

Ym1 polymorphism regulates alternative activation of macrophages leading to variable susceptibility to inflammatory diseases.

Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis Open

Yanpeng Li, Dongmei Tong, Peibin Liang, Erik Lönnblom, Johan Viljanen , et al. · 2020

Structural Basis of Cross‐Reactivity of Anti–Citrullinated Protein Antibodies Open

Changrong Ge, Bingze Xu, Bibo Liang, Erik Lönnblom, Susanna L. Lundström , et al. · 2018

Objective Anti–citrullinated protein antibodies ( ACPA s) develop many years before the clinical onset of rheumatoid arthritis ( RA ). This study was undertaken to address the molecular basis of the specificity and cross‐reactivity of ACPA…

The involvement of Toll‐like receptor 9 in the pathogenesis of erosive autoimmune arthritis Open

Anita Fischer, Shahla Abdollahi‐Roodsaz, Christina Böhm, Birgit Niederreiter, Brigitte Meyer , et al. · 2018

Endogenous nucleic acids and their receptors may be involved in the initiation of systemic autoimmune diseases including rheumatoid arthritis ( RA ). As the role of the DNA sensing Toll‐like receptor ( TLR ) 9 in RA is unclear, we aimed to…

A Shared Epitope of Collagen Type XI and Type II Is Recognized by Pathogenic Antibodies in Mice and Humans with Arthritis Open

Dongmei Tong, Erik Lönnblom, Anthony C. Y. Yau, Kutty Selva Nandakumar, Bibo Liang , et al. · 2018

CXI is immunologically not exposed in healthy cartilage but contains T and B cell epitopes cross-reactive with CII, which could be activated in both mouse and human arthritis and could evoke an arthritogenic response.

P020 Toll-like receptor 9 influences inflammatory arthritis and osteoclastogenesis Open

Anita Fischer, S Abdollahi-Rodsaz, ACY Yau, Erik Lönnblom, Rikard Holmdahl , et al. · 2018

Influence of hydrocarbon oil structure on adjuvanticity and autoimmunity Open

Anthony C. Y. Yau, Erik Lönnblom, Jianghong Zhong, Rikard Holmdahl · 2017

Mineral oils are extensively used in our daily life, in food, cosmetics, biomedicine, vaccines and in different industrial applications. However, exposure to these mineral oils has been associated with immune adjuvant effects and the devel…

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage Open

Changrong Ge, Dongmei Tong, Bibo Liang, Erik Lönnblom, Nadine Schneider , et al. · 2017

Today, it is known that autoimmune diseases start a long time before clinical symptoms appear. Anti-citrullinated protein antibodies (ACPAs) appear many years before the clinical onset of rheumatoid arthritis (RA). However, it is still unc…

SAT0031 Detection and isolation of antigen specific b cells in patients with rheumatoid arthritis Open

Jenny Nilsson, Maria Bergquist, Karin Önnheim, Inga‐Lill Mårtensson, Johan Viljanen , et al. · 2017

Regulation of autoantibody activity by the IL-23–TH17 axis determines the onset of autoimmune disease Open

René Pfeifle, Tobias Rothe, Natacha Ipseiz, Hans Ulrich Scherer, Stephan Culemann , et al. · 2016

Effects by periodontitis on pristane-induced arthritis in rats Open

Kaja Eriksson, Erik Lönnblom, Gregory Tour, Anna Kats, Piotr Mydel , et al. · 2016

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