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View article: Patient characteristics and perioperative outcomes in the Bypass Equipoise Sleeve Trial (BEST) compared to general metabolic bariatric practice in Sweden
Patient characteristics and perioperative outcomes in the Bypass Equipoise Sleeve Trial (BEST) compared to general metabolic bariatric practice in Sweden Open
View article: The effect of weight change on death and cardiovascular events after Roux-en-Y gastric bypass
The effect of weight change on death and cardiovascular events after Roux-en-Y gastric bypass Open
Background Weight changes after Roux-en-Y gastric bypass (RYGB) follow different trajectories, but the effects of different trajectories on death and cardiovascular events are largely unknown. The aim of the current study was therefore to …
View article: Superior normalization using total protein for western blot analysis of human adipocytes
Superior normalization using total protein for western blot analysis of human adipocytes Open
Western blotting has been a pivotal method for analyzing protein expression since the late 1970s, yet there is no established consensus on an optimal normalization strategy. In this study, primary mature human adipocytes were used to inves…
View article: Cardiovascular and diabetes outcomes among patients with obesity and type 2 diabetes after metabolic bariatric surgery or glucagon-like peptide 1 receptor agonist treatment
Cardiovascular and diabetes outcomes among patients with obesity and type 2 diabetes after metabolic bariatric surgery or glucagon-like peptide 1 receptor agonist treatment Open
Background With the increasing prevalence of obesity and type 2 diabetes, the availability of different treatment options remains essential. Studies comparing the outcomes of glucagon-like peptide 1 receptor agonists with those of metaboli…
View article: LLMSecCode: Evaluating Large Language Models for Secure Coding
LLMSecCode: Evaluating Large Language Models for Secure Coding Open
The rapid deployment of Large Language Models (LLMs) requires careful consideration of their effect on cybersecurity. Our work aims to improve the selection process of LLMs that are suitable for facilitating Secure Coding (SC). This raises…
View article: Senescence detection using reflected light
Senescence detection using reflected light Open
Senescence is an important cellular program occurring in development, tissue repair, cancer, and aging. Increased senescence is also associated with disease states, including obesity and Type 2 diabetes (T2D). Characterizing and quantifyin…
View article: 72269 - Ten-year results after primary gastric bypass for severe obesity: results from the Scandinavian Obesity Registry (SOReg)
72269 - Ten-year results after primary gastric bypass for severe obesity: results from the Scandinavian Obesity Registry (SOReg) Open
Introduction Metabolic and bariatric surgery (MBS) is part of routine care for patients with severe obesity (BMI >35 kg/m2). In Sweden, the Scandinavian Obesity Registry (SOReg) collects data on all MBS with follow-up at 1, 2, 5 and 10 …
View article: Comparison of Sleeve Gastrectomy vs Roux-en-Y Gastric Bypass
Comparison of Sleeve Gastrectomy vs Roux-en-Y Gastric Bypass Open
Importance Laparoscopic sleeve gastrectomy (SG) and laparoscopic Roux-en-Y gastric bypass (RYGB) are widely used bariatric procedures for which comparative efficacy and safety remain unclear. Objective To compare perioperative outcomes in …
View article: Decreased sarcomeric mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function independently of insulin action in type 2 diabetes
Decreased sarcomeric mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function independently of insulin action in type 2 diabetes Open
SUMMARY Plasma creatine levels are associated with risk of type 2 diabetes. Since skeletal muscle is the main disposal site of both creatine and glucose, we investigated the role of intramuscular creatine metabolism in the pathophysiology …
View article: Results from the Scandinavian Obesity Surgery Registry: A narrative review
Results from the Scandinavian Obesity Surgery Registry: A narrative review Open
Summary In 2007, the Scandinavian Obesity Surgery Registry (SOReg) was started by the profession to monitor the results of bariatric surgery and to provide a high‐quality database for research. In the end of August 2023, SOReg contains 88,…
View article: Human resident liver myeloid cells protect against metabolic stress in obesity
Human resident liver myeloid cells protect against metabolic stress in obesity Open
View article: Impact of socioeconomic status on new chronic opioid use after gastric bypass surgery
Impact of socioeconomic status on new chronic opioid use after gastric bypass surgery Open
Given that long-term opioid use has detrimental effects after bariatric surgery, it is important that information and follow-up are optimized for patients with shorter education, lower income, and disability pension or early retirement bec…
View article: Long-term Safety and Efficacy of Closure of Mesenteric Defects in Laparoscopic Gastric Bypass Surgery
Long-term Safety and Efficacy of Closure of Mesenteric Defects in Laparoscopic Gastric Bypass Surgery Open
Importance Short-term and midterm data suggest that mesenteric defects closure during laparoscopic Roux-en-Y gastric bypass (LRYGB) surgery reduces the risk of internal herniation with small bowel obstruction (SBO) but may increase risk of…
View article: Incidence of Kidney Stones After Metabolic and Bariatric Surgery—Data from the Scandinavian Obesity Surgery Registry
Incidence of Kidney Stones After Metabolic and Bariatric Surgery—Data from the Scandinavian Obesity Surgery Registry Open
View article: Major adverse cardiovascular events among patients with type-2 diabetes, a nationwide cohort study comparing primary metabolic and bariatric surgery to GLP-1 receptor agonist treatment
Major adverse cardiovascular events among patients with type-2 diabetes, a nationwide cohort study comparing primary metabolic and bariatric surgery to GLP-1 receptor agonist treatment Open
Background Glucagon-like Peptide-1 receptor agonists (GLP-1 RA) and metabolic and bariatric surgery (MBS) both improve cardiovascular outcomes in patients with severe obesity and type-2 diabetes (T2D). The aim of the present study was to a…
View article: Incidence of self‐harm after bariatric surgery: A nationwide registry‐based matched cohort study
Incidence of self‐harm after bariatric surgery: A nationwide registry‐based matched cohort study Open
Summary The aims of this study were to evaluate the longitudinal risk of self‐harm and the risk factors for self‐harm after bariatric surgery in patients and control subjects without prior self‐harm. This observational cohort study was bas…
View article: Association between attention deficit hyperactivity disorder and outcomes after metabolic and bariatric surgery: a nationwide propensity-matched cohort study
Association between attention deficit hyperactivity disorder and outcomes after metabolic and bariatric surgery: a nationwide propensity-matched cohort study Open
Compared with patients without ADHD, patients treated pharmacologically for ADHD experience similar weight loss and remission of obesity-related diseases without an increased risk for serious complications but report a lower health-related…
View article: Palmitate impairs circadian transcriptomics in muscle cells through histone modification of enhancers
Palmitate impairs circadian transcriptomics in muscle cells through histone modification of enhancers Open
Obesity and elevated circulating lipids may impair metabolism by disrupting the molecular circadian clock. We tested the hypothesis that lipid overload may interact with the circadian clock and alter the rhythmicity of gene expression thro…
View article: The effect of routine division of the greater omentum on small bowel obstruction after Roux-en-Y gastric bypass
The effect of routine division of the greater omentum on small bowel obstruction after Roux-en-Y gastric bypass Open
Division of the greater omentum is associated with reduced risk for SBO after antecolic, antegastric LRYGB and should be considered as a complement to mesenteric defects closure to further reduce the risk for SBO after LRYGB.
View article: Lipolysis defect in people with obesity who undergo metabolic surgery
Lipolysis defect in people with obesity who undergo metabolic surgery Open
Objective Cross‐sectional studies demonstrate that catecholamine stimulation of fat cell lipolysis is blunted in obesity. We investigated whether this defect persists after substantial weight loss has been induced by metabolic surgery, and…
View article: Safety of bariatric surgery in patients with previous acute coronary events or heart failure: nationwide cohort study
Safety of bariatric surgery in patients with previous acute coronary events or heart failure: nationwide cohort study Open
Background Metabolic (bariatric) surgery for patients with severe obesity and pre-existing heart disease has been reported to reduce the risk for cardiovascular events and mortality; however, concerns of short- and mid-term complications m…
View article: Major cardiovascular events after metabolic surgery in patients with previous heart disease with or without type 2 diabetes: a nationwide cohort study
Major cardiovascular events after metabolic surgery in patients with previous heart disease with or without type 2 diabetes: a nationwide cohort study Open
Metabolic surgery was associated with a reduced risk for MACE and mortality in patients with preexisting heart disease and T2D as well as in patients with heart disease without T2D. Patients with heart disease and T2D seem to experience th…
View article: Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes
Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes Open
Dysregulation of skeletal muscle metabolism influences whole body insulin sensitivity and glucose homeostasis. We hypothesized that type 2 diabetes-associated alterations in the plasma metabolome directly contribute to skeletal muscle immu…
View article: Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes
Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes Open
Dysregulation of skeletal muscle metabolism influences whole body insulin sensitivity and glucose homeostasis. We hypothesized that type 2 diabetes-associated alterations in the plasma metabolome directly contribute to skeletal muscle immu…
View article: Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes
Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes Open
Dysregulation of skeletal muscle metabolism influences whole-body insulin sensitivity and glucose homeostasis. We hypothesized that type 2 diabetes–associated alterations in the plasma metabolome directly contribute to skeletal muscle immu…
View article: Factors affecting relapse of type 2 diabetes after bariatric surgery in Sweden 2007–2015: a registry-based cohort study
Factors affecting relapse of type 2 diabetes after bariatric surgery in Sweden 2007–2015: a registry-based cohort study Open
Longer duration of T2D, higher preoperative HbA1C level, less postoperative weight loss, female sex, and insulin treatment prior to surgery are risk factors for T2D relapse after initial remission.
View article: Remission, relapse, and risk of major cardiovascular events after metabolic surgery in persons with hypertension: A Swedish nationwide registry-based cohort study
Remission, relapse, and risk of major cardiovascular events after metabolic surgery in persons with hypertension: A Swedish nationwide registry-based cohort study Open
Background Several studies have shown that metabolic surgery is associated with remission of diabetes and hypertension. In terms of diabetes, factors such as duration, insulin use, weight loss, and age have been shown to contribute to the …
View article: Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity
Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity Open
View article: Using a Convolutional Neural Network to Predict Remission of Diabetes After Gastric Bypass Surgery: Machine Learning Study From the Scandinavian Obesity Surgery Register
Using a Convolutional Neural Network to Predict Remission of Diabetes After Gastric Bypass Surgery: Machine Learning Study From the Scandinavian Obesity Surgery Register Open
Background Prediction of diabetes remission is an important topic in the evaluation of patients with type 2 diabetes (T2D) before bariatric surgery. Several high-quality predictive indices are available, but artificial intelligence algorit…
View article: Three weeks of interrupting sitting lowers fasting glucose and glycemic variability, but not glucose tolerance, in free-living women and men with obesity
Three weeks of interrupting sitting lowers fasting glucose and glycemic variability, but not glucose tolerance, in free-living women and men with obesity Open
Under free-living conditions, breaking sitting modestly increased activity behavior. Breaking sitting was insufficient to modulate glucose tolerance or the skeletal muscle lipidome. Activity breaks reduced fasting blood glucose levels and …