Erik R. Swenson
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View article: Mechanisms of ventilatory acclimatization to high altitude
Mechanisms of ventilatory acclimatization to high altitude Open
View article: Prophylactic caffeine mitigates systemic hypercapnia and headache during graded carbon dioxide exposure in healthy males and females: a randomized crossover trial
Prophylactic caffeine mitigates systemic hypercapnia and headache during graded carbon dioxide exposure in healthy males and females: a randomized crossover trial Open
In this study, we first characterized systemic hypercapnia and headache severity during graded CO 2 exposures (sequential 12-min stages of 0%, 2%, 4%, 6%, and 8% inspired CO 2 ). Using a randomized, double-blind, crossover trial, we then s…
View article: Correction to: The Lungs at the Extremes of Environment and Age
Correction to: The Lungs at the Extremes of Environment and Age Open
View article: A Triple Threat: A Case Report Detailing Surgical Management for Hypertrophic Cardiomyopathy, Flail Mitral Valve and Severe Pulmonary Hypertension
A Triple Threat: A Case Report Detailing Surgical Management for Hypertrophic Cardiomyopathy, Flail Mitral Valve and Severe Pulmonary Hypertension Open
The combination of hypertrophic cardiomyopathy with outflow tract obstruction, severe pre-capillary and post-capillary pulmonary hypertension, and severe primary mitral regurgitation is rare and presents distinct management challenges. Bac…
View article: Acute effect of acetazolamide on exercise haemodynamics in patients with pulmonary arterial and chronic thromboembolic pulmonary hypertension: a randomised controlled trial
Acute effect of acetazolamide on exercise haemodynamics in patients with pulmonary arterial and chronic thromboembolic pulmonary hypertension: a randomised controlled trial Open
Background The aim of this study was to investigate the acute effect of acetazolamide on pulmonary haemodynamics during exercise in patients with pulmonary vascular disease (PVD). Methods Patients with PVD diagnosed as pulmonary arterial (…
View article: Unsupervised Exercise in Interstitial Lung Disease
Unsupervised Exercise in Interstitial Lung Disease Open
View article: Individual assessment of ventilatory acclimatization at high altitude
Individual assessment of ventilatory acclimatization at high altitude Open
Acclimatization to high altitude is essential for the prevention of high-altitude illnesses such as acute mountain sickness (AMS), or life-threatening high-altitude cerebral and pulmonary oedemas, but also for the partial restoration of th…
View article: Asymmetric and symmetric dimethylarginine in high altitude pulmonary hypertension (HAPH) and high altitude pulmonary edema (HAPE)
Asymmetric and symmetric dimethylarginine in high altitude pulmonary hypertension (HAPH) and high altitude pulmonary edema (HAPE) Open
Introduction: High altitude exposure may lead to high altitude pulmonary hypertension (HAPH) and high altitude pulmonary edema (HAPE). The pathophysiologic processes of both entities have been linked to decreased nitric oxide (NO) availabi…
View article: Exercise in hypoxia: a model from laboratory to on-field studies
Exercise in hypoxia: a model from laboratory to on-field studies Open
Clinical outcome and quality of life of patients with chronic heart failure (HF) have greatly improved over the last two decades. These results and the availability of modern lifts allow many cardiac patients to spend leisure time at altit…
View article: European Respiratory Society/American Thoracic Society technical statement: standardisation of the measurement of lung volumes, 2023 update
European Respiratory Society/American Thoracic Society technical statement: standardisation of the measurement of lung volumes, 2023 update Open
This document updates the 2005 European Respiratory Society (ERS) and American Thoracic Society (ATS) technical standard for the measurement of lung volumes. The 2005 document integrated the recommendations of an ATS/ERS task force with th…
View article: Race and Ethnicity in Pulmonary Function Test Interpretation: An Official American Thoracic Society Statement
Race and Ethnicity in Pulmonary Function Test Interpretation: An Official American Thoracic Society Statement Open
Current American Thoracic Society (ATS) standards promote the use of race and ethnicity-specific reference equations for pulmonary function test (PFT) interpretation. There is rising concern that the use of race and ethnicity in PFT interp…
View article: Flying to high-altitude destinations: Is the risk of acute mountain sickness greater?
Flying to high-altitude destinations: Is the risk of acute mountain sickness greater? Open
Background Altitude sojourns increasingly attract individuals of all ages and different health statuses due to the appeal of high-altitude destinations worldwide and easy access to air travel. The risk of acute mountain sickness (AMS) when…
View article: Effect of 5 weeks of oral acetazolamide on patients with pulmonary vascular disease: A randomized, double-blind, cross-over trial
Effect of 5 weeks of oral acetazolamide on patients with pulmonary vascular disease: A randomized, double-blind, cross-over trial Open
NCT02755298.
View article: An update on environment-induced pulmonary edema – “When the lungs leak under water and in thin air”
An update on environment-induced pulmonary edema – “When the lungs leak under water and in thin air” Open
Acute pulmonary edema is a serious condition that may occur as a result of increased hydrostatic forces within the lung microvasculature or increased microvascular permeability. Heart failure or other cardiac or renal disease are common ca…
View article: Strengthening Altitude Knowledge: A Delphi Study to Define Minimum Knowledge of Altitude Illness for Laypersons Traveling to High Altitude
Strengthening Altitude Knowledge: A Delphi Study to Define Minimum Knowledge of Altitude Illness for Laypersons Traveling to High Altitude Open
Berendsen, Remco R., Peter Bärtsch, Buddha Basnyat, Marc Moritz Berger, Peter Hackett, Andrew M. Luks, Jean-Paul Richalet, Ken Zafren, Bengt Kayser, and the STAK Plenary Group. Strengthening altitude knowledge: a Delphi study to define min…
View article: A Celebration of the Extraordinary Life of Late Professor Tatiana V. Serebrovskaya (Kyiv, Ukraine) in Advancing Hypoxia Science and Medicine
A Celebration of the Extraordinary Life of Late Professor Tatiana V. Serebrovskaya (Kyiv, Ukraine) in Advancing Hypoxia Science and Medicine Open
ne of Ukraine's leading scientists and innovators
View article: Author Correction: Care-seeking and delay of care during COPD exacerbations
Author Correction: Care-seeking and delay of care during COPD exacerbations Open
View article: Concomitant Lung and Kidney Disorders in Critically Ill Patients: Core Curriculum 2022
Concomitant Lung and Kidney Disorders in Critically Ill Patients: Core Curriculum 2022 Open
View article: Myocardial and mitochondrial effects of the anhydrase carbonic inhibitor ethoxzolamide in ischemia‐reperfusion
Myocardial and mitochondrial effects of the anhydrase carbonic inhibitor ethoxzolamide in ischemia‐reperfusion Open
We have previously demonstrated that inhibition of extracellularly oriented carbonic anhydrase (CA) isoforms protects the myocardium against ischemia-reperfusion injury. In this study, our aim was to assess the possible further contributio…
View article: ANXIETY AND LOW SOCIAL SUPPORT ARE RISK FACTORS OF DEVELOPING SEVERE ACUTE EXACERBATIONS IN PATIENTS WITH COPD
ANXIETY AND LOW SOCIAL SUPPORT ARE RISK FACTORS OF DEVELOPING SEVERE ACUTE EXACERBATIONS IN PATIENTS WITH COPD Open
View article: Validity of Peripheral Oxygen Saturation Measurements with the Garmin Fēnix® 5X Plus Wearable Device at 4559 m
Validity of Peripheral Oxygen Saturation Measurements with the Garmin Fēnix® 5X Plus Wearable Device at 4559 m Open
Decreased oxygen saturation (SO2) at high altitude is associated with potentially life-threatening diseases, e.g., high-altitude pulmonary edema. Wearable devices that allow continuous monitoring of peripheral oxygen saturation (SpO2), suc…
View article: Does inspiration of exhaled CO2 explain improved oxygenation with a face mask plus high-flow nasal cannula oxygen in severe COVID-19 infection?
Does inspiration of exhaled CO2 explain improved oxygenation with a face mask plus high-flow nasal cannula oxygen in severe COVID-19 infection? Open
View article: Acetazolamide prevents hypoxia‐induced reactive oxygen species generation and calcium release in pulmonary arterial smooth muscle
Acetazolamide prevents hypoxia‐induced reactive oxygen species generation and calcium release in pulmonary arterial smooth muscle Open
Upon sensing a reduction in local oxygen partial pressure, pulmonary vessels constrict, a phenomenon known as hypoxic pulmonary vasoconstriction. Excessive hypoxic pulmonary vasoconstriction can occur with ascent to high altitude and is a …
View article: Acute Hemodynamic Effect of Acetazolamide in Patients With Pulmonary Hypertension Whilst Breathing Normoxic and Hypoxic Gas: A Randomized Cross-Over Trial
Acute Hemodynamic Effect of Acetazolamide in Patients With Pulmonary Hypertension Whilst Breathing Normoxic and Hypoxic Gas: A Randomized Cross-Over Trial Open
Aims: To test the acute hemodynamic effect of acetazolamide in patients with pulmonary hypertension (PH) under ambient air and hypoxia. Methods: Patients with pulmonary arterial or chronic thromboembolic PH (PAH/CTEPH) undergoing right hea…
View article: Pathophysiology of Acute Respiratory Distress Syndrome and COVID-19 Lung Injury
Pathophysiology of Acute Respiratory Distress Syndrome and COVID-19 Lung Injury Open
View article: Discrepancies Between Patient-Reported and Pharmacy Refill Data Measures of Inhaler Adherence in Veterans with COPD
Discrepancies Between Patient-Reported and Pharmacy Refill Data Measures of Inhaler Adherence in Veterans with COPD Open
View article: Acute Hemodynamic Effect of Acetazolamide in Patients with Pulmonary Hypertensionwhilst Breathing Normoxic and Hypoxic Air: A Randomized Cross-Over Trial
Acute Hemodynamic Effect of Acetazolamide in Patients with Pulmonary Hypertensionwhilst Breathing Normoxic and Hypoxic Air: A Randomized Cross-Over Trial Open
View article: In vitro validation and characterization of pulsed inhaled nitric oxide administration during early inspiration
In vitro validation and characterization of pulsed inhaled nitric oxide administration during early inspiration Open
View article: The Pathophysiology and Dangers of Silent Hypoxemia in COVID-19 Lung Injury
The Pathophysiology and Dangers of Silent Hypoxemia in COVID-19 Lung Injury Open
The ongoing coronavirus disease (COVID-19) pandemic has been unprecedented on many levels, not least of which are the challenges in understanding the pathophysiology of these new critically ill patients. One widely reported phenomenon is t…
View article: Chemoreceptor hyperactivity in heart failure: is lactate the culprit?
Chemoreceptor hyperactivity in heart failure: is lactate the culprit? Open
we propose that in patients with HF, the blunted cardiac output during exercise results in inadequate oxygen delivery to working muscle, and earlier anaerobic metabolism which increase both lactate production and H+ and both are stimulus t…