Erik Schéle
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View article: Unfermented High‐Fiber Rye Crispbread Increases Plasma HDL and Reduces Hepatic Lipids Compared to Refined Wheat in Rats Fed a High‐Fat Diet
Unfermented High‐Fiber Rye Crispbread Increases Plasma HDL and Reduces Hepatic Lipids Compared to Refined Wheat in Rats Fed a High‐Fat Diet Open
Fiber‐rich rye foods reduced body weight in overweight or obese individuals compared to refined wheat, though the underlying mechanisms remain unclear. This study compared the effects of whole grain fermented and unfermented rye with refin…
View article: Chemogenetic re-activation of a neuronal ensemble in the lateral hypothalamus that is active during activity-based anorexia in mice modulates feeding and running activity
Chemogenetic re-activation of a neuronal ensemble in the lateral hypothalamus that is active during activity-based anorexia in mice modulates feeding and running activity Open
A high level of physical activity is common in patients with anorexia nervosa and can exacerbate symptoms and recovery prognosis. The underlying cause is not known but is most likely regulated by the brain and may derive from energy defici…
View article: Intranasal Delivery of a Ghrelin Mimetic Engages the Brain Ghrelin Signaling System in Mice
Intranasal Delivery of a Ghrelin Mimetic Engages the Brain Ghrelin Signaling System in Mice Open
Ghrelin, the endogenous ligand of the growth hormone secretagogue receptor (GHSR), promotes food intake and other feeding behaviors, and stimulates growth hormone (GH) release from the pituitary. Growth hormone secretagogues (GHS), such as…
View article: To eat or not to eat: A role for ghrelin and LEAP2 in eating disorders?
To eat or not to eat: A role for ghrelin and LEAP2 in eating disorders? Open
Ghrelin is an orexigenic hormone that orchestrates many diverse behaviours of relevance for feeding control. It appears to operate as a hunger hormone, organizing food intake into meals and ensuring that we seek out and consume a variety o…
View article: Ghrelin is related to lower brain reward activation during touch
Ghrelin is related to lower brain reward activation during touch Open
The gut hormone ghrelin drives food motivation and increases food intake, but it is also involved in the anticipation of and response to rewards other than food. This pre‐registered study investigated how naturally varying ghrelin concentr…
View article: The dual hypothesis of homeostatic body weight regulation, including gravity-dependent and leptin-dependent actions
The dual hypothesis of homeostatic body weight regulation, including gravity-dependent and leptin-dependent actions Open
Body weight is tightly regulated when outside the normal range. It has been proposed that there are individual-specific lower and upper intervention points for when the homeostatic regulation of body weight is initiated. The nature of the …
View article: Engagement of the brain orexin system in activity-based anorexia behaviour in mice
Engagement of the brain orexin system in activity-based anorexia behaviour in mice Open
While excessive physical activity is common amongst anorexia nervosa (AN) patients, contributing to their low body weight, little is known about the underlying biology and effective treatments targeting the hyperactivity are lacking. Given…
View article: Ghrelin is related to lower brain reward activation during touch
Ghrelin is related to lower brain reward activation during touch Open
The gut hormone ghrelin drives food motivation and increases food intake, but it is also involved in the anticipation of and response to rewards other than food. This pre-registered study investigated how naturally varying ghrelin concentr…
View article: TRAPing Ghrelin-Activated Circuits: A Novel Tool to Identify, Target and Control Hormone-Responsive Populations in TRAP2 Mice
TRAPing Ghrelin-Activated Circuits: A Novel Tool to Identify, Target and Control Hormone-Responsive Populations in TRAP2 Mice Open
The availability of Cre-based mouse lines for visualizing and targeting populations of hormone-sensitive cells has helped identify the neural circuitry driving hormone effects. However, these mice have limitations and may not even be avail…
View article: A skeleton in the cupboard in ghrelin research: Where are the skinny dwarfs?
A skeleton in the cupboard in ghrelin research: Where are the skinny dwarfs? Open
Based on studies delivering ghrelin or ghrelin receptor agonists, we have learned a great deal about the importance of the brain ghrelin signalling system for a wide range of physiological processes that include feeding behaviours, growth …
View article: A Body Weight Sensor Regulates Prepubertal Growth via the Somatotropic Axis in Male Rats
A Body Weight Sensor Regulates Prepubertal Growth via the Somatotropic Axis in Male Rats Open
In healthy conditions, prepubertal growth follows an individual specific growth channel. Growth hormone (GH) is undoubtedly the major regulator of growth. However, the homeostatic regulation to maintain the individual specific growth chann…
View article: Functional and Neurochemical Identification of Ghrelin Receptor (GHSR)-Expressing Cells of the Lateral Parabrachial Nucleus in Mice
Functional and Neurochemical Identification of Ghrelin Receptor (GHSR)-Expressing Cells of the Lateral Parabrachial Nucleus in Mice Open
The lateral parabrachial nucleus (lPBN), located in the pons, is a well-recognized anorexigenic center harboring, amongst others, the calcitonin gene-related peptide (CGRP)-expressing neurons that play a key role. The receptor for the orex…
View article: Zona incerta neurons projecting to the ventral tegmental area promote action initiation towards feeding
Zona incerta neurons projecting to the ventral tegmental area promote action initiation towards feeding Open
Key points The zona incerta (ZI) and ventral tegmental area (VTA) are brain areas that are both implicated in feeding behaviour. The ZI projects to the VTA, although it has not yet been investigated whether this projection regulates feedin…
View article: 0317 Impact of Recurrent Partial Sleep Loss Combined with Acute Exercise on Circulating and Adipose Tissue Levels of Leptin, Adiponectin and Ghrelin in Healthy Young Individuals
0317 Impact of Recurrent Partial Sleep Loss Combined with Acute Exercise on Circulating and Adipose Tissue Levels of Leptin, Adiponectin and Ghrelin in Healthy Young Individuals Open
Introduction Chronic sleep loss and aerobic exercise have opposing effects on body weight maintenance. The effects of sleep loss on circulating levels of the orexigenic hormone ghrelin and the anorexigenic hormone leptin have been extensiv…
View article: Rats that are predisposed to excessive obesity show reduced (leptin‐induced) thermoregulation even in the preobese state
Rats that are predisposed to excessive obesity show reduced (leptin‐induced) thermoregulation even in the preobese state Open
Both feeding behavior and thermogenesis are regulated by leptin. The sensitivity to leptin's anorexigenic effects on chow diet was previously shown to predict the development of diet-induced obesity. In this study, we determined whether th…
View article: Divergent Metabolic Effects of Acute Versus Chronic Repeated Forced Swim Stress in the Rat
Divergent Metabolic Effects of Acute Versus Chronic Repeated Forced Swim Stress in the Rat Open
Objective This study sought to examine divergence regarding the impact of acute versus chronic repeated stress on energy balance. Methods Rats were exposed to either chronic repeated forced swim (FS) stress for 7 days or an acute stress (a…
View article: Impact of Free‐Choice Diets High in Fat and Different Sugars on Metabolic Outcome and Anxiety‐Like Behavior in Rats
Impact of Free‐Choice Diets High in Fat and Different Sugars on Metabolic Outcome and Anxiety‐Like Behavior in Rats Open
Objective Rats were exposed to free‐choice diets (fat plus one of two different sugar solutions, glucose or sucrose), and the metabolic consequences and impact on locomotor activity and anxiety‐like behavior were explored. Methods For 3 we…
View article: Activation of the rat hypothalamic supramammillary nucleus by food anticipation, food restriction or ghrelin administration
Activation of the rat hypothalamic supramammillary nucleus by food anticipation, food restriction or ghrelin administration Open
The circulating orexigenic hormone ghrelin targets many brain areas involved in feeding control and signals via a dedicated receptor, the growth hormone secretagogue receptor 1A. One unexplored target area for ghrelin is the supramammillar…
View article: Body weight homeostat that regulates fat mass independently of leptin in rats and mice
Body weight homeostat that regulates fat mass independently of leptin in rats and mice Open
Significance The only known homeostatic regulator of fat mass is the leptin system. We hypothesized that there is a second homeostat regulating body weight with an impact on fat mass. In this study we have added and removed weight loads fr…
View article: Functional interleukin‐6 receptor‐α is located in tanycytes at the base of the third ventricle
Functional interleukin‐6 receptor‐α is located in tanycytes at the base of the third ventricle Open
Interleukin ( IL )‐6 − / − mice develop mature onset obesity, whereas i.c.v. injection of IL ‐6 decreases obesity in rodents. Moreover, levels of IL ‐6 in cerebrospinal fluid ( CSF ) were reported to be inversely correlated with obesity in…
View article: Central administration of ghrelin induces conditioned avoidance in rodents
Central administration of ghrelin induces conditioned avoidance in rodents Open
Feelings of hunger carry a negative-valence (emotion) signal that appears to be conveyed through agouti-related peptide (AgRP) neurons in the hypothalamic arcuate nucleus. The circulating hunger hormone, ghrelin, activates these neurons al…
View article: Female Mice Lacking Estrogen Receptor-α in Hypothalamic Proopiomelanocortin (POMC) Neurons Display Enhanced Estrogenic Response on Cortical Bone Mass
Female Mice Lacking Estrogen Receptor-α in Hypothalamic Proopiomelanocortin (POMC) Neurons Display Enhanced Estrogenic Response on Cortical Bone Mass Open
Estrogens are important regulators of bone mass and their effects are mainly mediated via estrogen receptor (ER)α. Central ERα exerts an inhibitory role on bone mass. ERα is highly expressed in the arcuate (ARC) and the ventromedial (VMN) …
View article: Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca<sup>2+</sup> influx in response to IL-6
Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca<sup>2+</sup> influx in response to IL-6 Open
Neuronal circuits in the hypothalamus and hindbrain are of importance for control of food intake, energy expenditure, and fat mass. We have recently shown that treatment with exendin-4 (Ex-4), an analog of the proglucagon-derived molecule …