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View article: Cardiopulmonary and Immune Alterations in the Ts65Dn Mouse Model of Down Syndrome and Modulation by Epigallocatechin-3-Gallate-Enriched Green Tea Extract
Cardiopulmonary and Immune Alterations in the Ts65Dn Mouse Model of Down Syndrome and Modulation by Epigallocatechin-3-Gallate-Enriched Green Tea Extract Open
Background/Objectives: Cardiovascular and pulmonary diseases are leading comorbidities n individuals with Down syndrome (DS). Although clinically well described, preclinical models fully characterizing these cardiopulmonary alterations are…
View article: Transvalvular Mechanical Circulatory Support Reverse Remodels the Ischemic Chronic Failing Heart in an Ovine Model
Transvalvular Mechanical Circulatory Support Reverse Remodels the Ischemic Chronic Failing Heart in an Ovine Model Open
View article: Damping excessive viral-induced IFN-γ rescues the impaired anti-Aspergillus host immune response in influenza-associated pulmonary aspergillosis
Damping excessive viral-induced IFN-γ rescues the impaired anti-Aspergillus host immune response in influenza-associated pulmonary aspergillosis Open
View article: The nature of chronic rejection after lung transplantation: a murine orthotopic lung transplant study
The nature of chronic rejection after lung transplantation: a murine orthotopic lung transplant study Open
Introduction Chronic rejection is a major complication post-transplantation. Within lung transplantation, chronic rejection was considered as airway centred. Chronic Lung Allograft Dysfunction (CLAD), defined to cover all late chronic comp…
View article: Transvalvular Mechanical Circulatory Support Reverse Remodels the Ischemic Chronic Failing Heart in an Ovine Model
Transvalvular Mechanical Circulatory Support Reverse Remodels the Ischemic Chronic Failing Heart in an Ovine Model Open
View article: A Pathology-based Case Series of Influenza- and COVID-19–associated Pulmonary Aspergillosis: The Proof Is in the Tissue
A Pathology-based Case Series of Influenza- and COVID-19–associated Pulmonary Aspergillosis: The Proof Is in the Tissue Open
Rationale: Invasive pulmonary aspergillosis has emerged as a frequent coinfection in severe coronavirus disease (COVID-19), similarly to influenza, yet the clinical invasiveness is more debated. Objectives: We investigated th…
View article: Visualising SARS-CoV-2 infection of the lung in deceased COVID-19 patients
Visualising SARS-CoV-2 infection of the lung in deceased COVID-19 patients Open
View article: Cardiopulmonary structural, functional and immune-alterations in a Down syndrome mouse model and upon modulation of EGCG
Cardiopulmonary structural, functional and immune-alterations in a Down syndrome mouse model and upon modulation of EGCG Open
In individuals with Down syndrome (DS), cardiovascular and pulmonary diseases are the most common health problem and result in increased mortality and morbidity. Although these clinical comorbidities are well described, no preclinical mode…
View article: Intra-host emergence of an enterovirus A71 variant with enhanced PSGL1 usage and neurovirulence
Intra-host emergence of an enterovirus A71 variant with enhanced PSGL1 usage and neurovirulence Open
Enterovirus A71 (EV-A71) is one of the main causative agents of hand-foot-and-mouth disease and is occasionally associated with severe neurological complications. EV-A71 pathophysiology is poorly understood due to the lack of small animal …
View article: Effects of repeated infections with non-typeable Haemophilus influenzae on lung in vitamin D deficient and smoking mice
Effects of repeated infections with non-typeable Haemophilus influenzae on lung in vitamin D deficient and smoking mice Open
View article: Overcome Double Trouble: Baloxavir Marboxil Suppresses Influenza Thereby Mitigating Secondary Invasive Pulmonary Aspergillosis
Overcome Double Trouble: Baloxavir Marboxil Suppresses Influenza Thereby Mitigating Secondary Invasive Pulmonary Aspergillosis Open
Influenza-associated pulmonary aspergillosis (IAPA) is a global recognized superinfection in critically ill influenza patients. Baloxavir marboxil, a cap-dependent endonuclease inhibitor, is a newly approved anti-influenza therapeutic. Alt…
View article: Oxygenated machine perfusion at room temperature as an alternative for static cold storage in porcine donor hearts
Oxygenated machine perfusion at room temperature as an alternative for static cold storage in porcine donor hearts Open
Background There is a continued interest in ex situ heart perfusion as an alternative strategy for donor heart preservation. We hypothesize that oxygenated machine perfusion of donor hearts at a temperature that avoids both normothermia an…
View article: Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model
Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model Open
Invasive pulmonary aspergillosis (IPA) is a life-threatening fungal infection occurring mainly in immunocompromised patients. We recently identified IPA as an emerging co-infection with high mortality in critically ill, but otherwise immun…
View article: Connective Tissue Growth Factor Is Overexpressed in Explant Lung Tissue and Broncho-Alveolar Lavage in Transplant-Related Pulmonary Fibrosis
Connective Tissue Growth Factor Is Overexpressed in Explant Lung Tissue and Broncho-Alveolar Lavage in Transplant-Related Pulmonary Fibrosis Open
Background Connective tissue growth factor (CTGF) is an important mediator in several fibrotic diseases, including lung fibrosis. We investigated CTGF-expression in chronic lung allograft dysfunction (CLAD) and pulmonary graft-versus-host …
View article: Lung Functioning and Inflammation in a Mouse Model of Systemic Juvenile Idiopathic Arthritis
Lung Functioning and Inflammation in a Mouse Model of Systemic Juvenile Idiopathic Arthritis Open
Systemic juvenile idiopathic arthritis (sJIA) is an immune disorder characterized by fever, skin rash, arthritis and splenomegaly. Recently, increasing number of sJIA patients were reported having lung disease. Here, we explored lung abnor…
View article: Vitamin D Deficiency Enhances Non-typeable Haemophilus Influenzae Clearance During Repeated Infections but Worsens Lung Function, Irrespective of Cigarette Smoke Exposure
Vitamin D Deficiency Enhances Non-typeable Haemophilus Influenzae Clearance During Repeated Infections but Worsens Lung Function, Irrespective of Cigarette Smoke Exposure Open
View article: Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model
Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model Open
Invasive pulmonary aspergillosis (IPA) is a life-threatening fungal infection occurring mainly in immunocompromised patients. We recently identified IPA as an emerging co-infection with high mortality in critically ill, but otherwise immun…
View article: Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model
Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model Open
Invasive pulmonary aspergillosis (IPA) is a life-threatening fungal infection occurring mainly in immunocompromised patients. We recently identified IPA as an emerging co-infection with high mortality in critically ill, but otherwise immun…
View article: Intra-host emergence of an enterovirus A71 variant with enhanced PSGL1 usage and neurovirulence
Intra-host emergence of an enterovirus A71 variant with enhanced PSGL1 usage and neurovirulence Open
Enterovirus A71 (EV-A71) is one of the main causative agents of hand-foot-and-mouth disease and is occasionally associated with severe neurological complications. EV-A71 pathophysiology is poorly understood due to the lack of small animal …
View article: Involvement of Innate Lymphoid Cells and Dendritic Cells in a Mouse Model of Chemical-induced Asthma
Involvement of Innate Lymphoid Cells and Dendritic Cells in a Mouse Model of Chemical-induced Asthma Open
TDI-induced asthma is mediated by a predominant type 2 immune response, with the involvement of adaptive Th2 cells. However, from our study we suggest that the innate ILC2 cells are important additional players in the development of TDI-in…
View article: Free Airway C4d after Lung Transplantation - A Quantitative Analysis of Bronchoalveolar Lavage Fluid
Free Airway C4d after Lung Transplantation - A Quantitative Analysis of Bronchoalveolar Lavage Fluid Open
View article: Common occurrence of Belerina virus, a novel paramyxovirus found in Belgian hedgehogs
Common occurrence of Belerina virus, a novel paramyxovirus found in Belgian hedgehogs Open
View article: Longitudinal micro-computed tomography-derived biomarkers quantify non-resolving lung fibrosis in a silicosis mouse model
Longitudinal micro-computed tomography-derived biomarkers quantify non-resolving lung fibrosis in a silicosis mouse model Open
In spite of many compounds identified as antifibrotic in preclinical studies, pulmonary fibrosis remains a life-threatening condition for which highly effective treatment is still lacking. Towards improving the success-rate of bench-to-bed…
View article: From Mouse to Man and Back: Closing the Correlation Gap between Imaging and Histopathology for Lung Diseases
From Mouse to Man and Back: Closing the Correlation Gap between Imaging and Histopathology for Lung Diseases Open
Lung diseases such as fibrosis, asthma, cystic fibrosis, infection and cancer are life-threatening conditions that slowly deteriorate quality of life and for which our diagnostic power is high, but our knowledge on etiology and/or effectiv…
View article: Cobalt exposure via skin alters immune cells in lung and enhances pulmonary responses to cobalt in a mouse model
Cobalt exposure via skin alters immune cells in lung and enhances pulmonary responses to cobalt in a mouse model Open
Background: Cobalt has been associated with allergic contact dermatitis and occupational asthma. However, the link between skin exposure and lung responses to cobalt is currently unknown. We investigated the effect of prior dermal sensitiz…
View article: An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates
An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates Open
View article: Quantitative analysis of airway obstruction in lymphangioleiomyomatosis
Quantitative analysis of airway obstruction in lymphangioleiomyomatosis Open
Lymphangioleiomyomatosis (LAM) is a rare, cystic lung disease with progressive pulmonary function loss caused by progressively proliferating LAM cells. The degree of airway obstruction has not been well investigated within the pathogenesis…
View article: Small airways pathology in idiopathic pulmonary fibrosis: a retrospective cohort study
Small airways pathology in idiopathic pulmonary fibrosis: a retrospective cohort study Open
View article: Identification and characterization of chronic lung allograft dysfunction patients with mixed phenotype: A single‐center study
Identification and characterization of chronic lung allograft dysfunction patients with mixed phenotype: A single‐center study Open
Rationale Patients can change chronic lung allograft dysfunction (CLAD) phenotype, especially from BOS to mixed phenotype. Our aim was to further characterize these patients. Method Mixed CLAD was defined as a restrictive physiology with p…
View article: An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates
An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates Open