Erik W. Holy
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View article: Cocaine-induced acute myocardial infarction: angiographic features and outcomes
Cocaine-induced acute myocardial infarction: angiographic features and outcomes Open
Background Cocaine is a global health burden and the cause of a significant number of emergency department consultations. Its association with acute myocardial infarction (AMI) is known, however, data are still rare. The aim of this study …
View article: The effect of antibody-mediated PCSK9 inhibitor on bare-metal stent implantation outcome
The effect of antibody-mediated PCSK9 inhibitor on bare-metal stent implantation outcome Open
Introduction Percutaneous coronary intervention (PCI) is the gold standard for the management of acute coronary syndrome, and has been benefited from advances in pharmacotherapy and device innovation. Nevertheless, in-stent restenosis and …
View article: Clinical outcomes of a balloon-expandable stent for symptomatic obstructions of the subclavian or innominate arteries
Clinical outcomes of a balloon-expandable stent for symptomatic obstructions of the subclavian or innominate arteries Open
Summary: Background: Upper-extremity peripheral arterial disease (PAD) may present with a broad spectrum of signs and symptoms. If an endovascular treatment is planned, percutaneous angioplasty and stent placement may lead to a better pate…
View article: Antibody-mediated PCSK9 neutralization worsens outcome after bare-metal stent implantation in mice
Antibody-mediated PCSK9 neutralization worsens outcome after bare-metal stent implantation in mice Open
Antibody-based PCSK9 inhibition promotes in-stent intimal hyperplasia and blunts vascular healing by increasing VSMC migration, while reducing that of EC. This effect is likely mediated, at least in part, by a differential effect on VSMC a…
View article: Clinical outcomes of ultrasound-assisted coagulation monitoring-adjusted catheter-directed thrombolysis for acute pulmonary embolism
Clinical outcomes of ultrasound-assisted coagulation monitoring-adjusted catheter-directed thrombolysis for acute pulmonary embolism Open
View article: Percutaneous large-bore aspiration embolectomy with veno-arterial extracorporal membrane oxygenation support or standby in patients with high-risk pulmonary embolism and contraindications to thrombolysis: a preliminary single centre experience
Percutaneous large-bore aspiration embolectomy with veno-arterial extracorporal membrane oxygenation support or standby in patients with high-risk pulmonary embolism and contraindications to thrombolysis: a preliminary single centre experience Open
Aims Large-bore catheter aspiration embolectomy reduces thrombus burden and right ventricle strain and improves haemodynamics after pulmonary embolism (PE). Sparse data are available for patients with high-risk PE and contraindications to …
View article: Major adverse limb events in patients with femoro-popliteal and below-the-knee peripheral arterial disease treated with either sirolimus-coated balloon or standard uncoated balloon angioplasty: a structured protocol summary of the “SirPAD” randomized controlled trial
Major adverse limb events in patients with femoro-popliteal and below-the-knee peripheral arterial disease treated with either sirolimus-coated balloon or standard uncoated balloon angioplasty: a structured protocol summary of the “SirPAD” randomized controlled trial Open
View article: Postprocedural Troponin Elevation and Mortality After Transcatheter Aortic Valve Implantation
Postprocedural Troponin Elevation and Mortality After Transcatheter Aortic Valve Implantation Open
Background This study sought to investigate the role of postprocedural troponin elevations in mortality prediction after transcatheter aortic valve implantation and to define the threshold at which clinically relevant postprocedure myocard…
View article: Outcomes of acute coronary syndromes in coronavirus disease 2019
Outcomes of acute coronary syndromes in coronavirus disease 2019 Open
View article: A young woman with recurrent spontaneous coronary artery dissection
A young woman with recurrent spontaneous coronary artery dissection Open
View article: Impact of a nationwide COVID-19 lockdown on acute coronary syndrome referrals
Impact of a nationwide COVID-19 lockdown on acute coronary syndrome referrals Open
View article: Myocardial edema in COVID-19 on cardiac MRI
Myocardial edema in COVID-19 on cardiac MRI Open
View article: Interleukin-1β Mediates Arterial Thrombus Formation via NET-Associated Tissue Factor
Interleukin-1β Mediates Arterial Thrombus Formation via NET-Associated Tissue Factor Open
CANTOS reported reduced secondary atherothrombotic events in patients with residual inflammatory risk treated with the inhibitory anti-IL-1β antibody, Canakinumab. Yet, mechanisms that underlie this benefit remain elusive. Recent work has …
View article: Incidence, predictors and cerebrovascular consequences of leaflet thrombosis after transcatheter aortic valve implantation: a systematic review and meta-analysis
Incidence, predictors and cerebrovascular consequences of leaflet thrombosis after transcatheter aortic valve implantation: a systematic review and meta-analysis Open
OBJECTIVES We examined the incidence, the impact of subsequent cerebrovascular events and the clinical or procedural predictors of leaflet thrombosis (LT) in patients undergoing transcatheter aortic valve implantation (TAVI). METHODS MEDLI…
View article: P2260Long-term durability and hemodynamic performance of a self-expanding transcatheter heart valve beyond 5 years after implantation: a prospective observational study applying the standardized definition
P2260Long-term durability and hemodynamic performance of a self-expanding transcatheter heart valve beyond 5 years after implantation: a prospective observational study applying the standardized definition Open
View article: Long-term durability and haemodynamic performance of a self-expanding transcatheter heart valve beyond five years after implantation: a prospective observational study applying the standardised definitions of structural deterioration and valve failure
Long-term durability and haemodynamic performance of a self-expanding transcatheter heart valve beyond five years after implantation: a prospective observational study applying the standardised definitions of structural deterioration and valve failure Open
Long-term follow-up up to 8.9 years after TAVI documents favourable performance of the self-expanding CoreValve with low rates of BVF.
View article: A Novel Angiographic Quantification of Aortic Regurgitation After TAVR Provides an Accurate Estimation of Regurgitation Fraction Derived From Cardiac Magnetic Resonance Imaging
A Novel Angiographic Quantification of Aortic Regurgitation After TAVR Provides an Accurate Estimation of Regurgitation Fraction Derived From Cardiac Magnetic Resonance Imaging Open
View article: Long-Term Clinical Outcome of Early Generation Versus New-Generation Drug-Eluting Stents in 481 Patients Undergoing Rotational Atherectomy: A Retrospective Analysis
Long-Term Clinical Outcome of Early Generation Versus New-Generation Drug-Eluting Stents in 481 Patients Undergoing Rotational Atherectomy: A Retrospective Analysis Open
View article: P2966Quantitative assessment of prosthetic valve regurgitation after TAVI by angiography and cardiac magnetic resonance imaging
P2966Quantitative assessment of prosthetic valve regurgitation after TAVI by angiography and cardiac magnetic resonance imaging Open
View article: Shifting paradigms for treatment of symptomatic aortic stenosis in lower risk populations: role of a newer generation balloon-expandable transcatheter aortic valve implantation device
Shifting paradigms for treatment of symptomatic aortic stenosis in lower risk populations: role of a newer generation balloon-expandable transcatheter aortic valve implantation device Open
Over the last decade, transcatheter aortic valve implantation (TAVI) has emerged as the treatment of choice for patients with symptomatic severe aortic valve stenosis at a prohibitive or high risk for surgical valve replacement. Since its …
View article: Comparison of dual antiplatelet therapy versus oral anticoagulation following transcatheter aortic valve replacement: A retrospective single-center registry analysis
Comparison of dual antiplatelet therapy versus oral anticoagulation following transcatheter aortic valve replacement: A retrospective single-center registry analysis Open
OAC after TAVR seems to reduce the risk of clinical valve thrombosis without a statisti-cally significant increase in bleeding complications.
View article: Outcomes in Transcatheter Aortic Valve Replacement for Bicuspid Versus Tricuspid Aortic Valve Stenosis
Outcomes in Transcatheter Aortic Valve Replacement for Bicuspid Versus Tricuspid Aortic Valve Stenosis Open
Compared with tricuspid AS, TAVR in bicuspid AS was associated with a similar prognosis, but lower device success rate. Procedural differences were observed in patients treated with the early-generation devices, whereas no differences were…
View article: Endothelial LOX-1 activation differentially regulates arterial thrombus formation depending on oxLDL levels: role of the Oct-1/SIRT1 and ERK1/2 pathways
Endothelial LOX-1 activation differentially regulates arterial thrombus formation depending on oxLDL levels: role of the Oct-1/SIRT1 and ERK1/2 pathways Open
Thus, LOX-1 differentially regulates thrombus formation in vivo depending on the degree of activation by oxLDL. At low oxLDL levels LOX-1 activates the protective Oct-1/SIRT1 pathway, while at higher levels of the lipoprotein switches to t…
View article: Ticagrelor, but not clopidogrel active metabolite, displays antithrombotic properties in the left atrial endocardium
Ticagrelor, but not clopidogrel active metabolite, displays antithrombotic properties in the left atrial endocardium Open
Ticagrelor, but not CAM, reduces expression and activity of TF and PAI-1 in LAA endocardial cells isolated from patients with AF, indicating possible local antithrombotic effects. Such pleiotropic properties of ticagrelor may contribute to…