Elisa Aguirre
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View article: Remote, lower-intensity, multidomain lifestyle intervention for subjective cognitive decline or mild cognitive impairment (APPLE-Tree): a multicentre, single-masked, randomised controlled trial
Remote, lower-intensity, multidomain lifestyle intervention for subjective cognitive decline or mild cognitive impairment (APPLE-Tree): a multicentre, single-masked, randomised controlled trial Open
Economic and Social Research Council and National Institute for Health and Care Research programme grant.
View article: Advancements in Facial Reconstruction Surgery: The Role of Bioengineered Materials, Artificial Intelligence, and 3D Printing in Addressing Economic Disparities
Advancements in Facial Reconstruction Surgery: The Role of Bioengineered Materials, Artificial Intelligence, and 3D Printing in Addressing Economic Disparities Open
The advancement of science and technology is an undeniable phenomenon that is progressively transforming all aspects of human life, including scientific, social, humanitarian, and environmental fields, among others. Facial reconstruction s…
View article: Group cognitive stimulation therapy for people with intellectual disability and dementia: feasibility randomised controlled trial
Group cognitive stimulation therapy for people with intellectual disability and dementia: feasibility randomised controlled trial Open
Background Group cognitive stimulation therapy (CST) has been shown to improve cognition and quality of life of people with dementia in multiple trials, but there has been scant research involving people with intellectual disability and de…
View article: Cognitive Stimulation Therapy—Spain (CST‐ES): Cultural Adaptation Process and Pilot Study
Cognitive Stimulation Therapy—Spain (CST‐ES): Cultural Adaptation Process and Pilot Study Open
Objectives To assess the validity and acceptability of an adapted version of Cognitive Stimulation Therapy (CST) for the Spanish population and culturally adapt the original UK manuals. Methods The process followed the Formative Method for…
View article: Process Evaluation of APPLE-Tree (Active Prevention in People at risk of dementia through Lifestyle bEhaviour Change and Technology to build REsiliEnce), a Dementia-Prevention Study focused on Health and Lifestyle changes
Process Evaluation of APPLE-Tree (Active Prevention in People at risk of dementia through Lifestyle bEhaviour Change and Technology to build REsiliEnce), a Dementia-Prevention Study focused on Health and Lifestyle changes Open
Introduction In a mixed-methods process evaluation embedded within a randomised controlled trial, we aimed to investigate how the APPLE-Tree secondary dementia prevention intervention might support behavioural and lifestyle goal attainment…
View article: Protocol to evaluate the effectiveness of the implementation of transdiagnostic cognitive behavioural therapy for emotional disorders in primary care and its mechanisms of change: a randomized step-wedge clinical trial (PsicAP-CV)
Protocol to evaluate the effectiveness of the implementation of transdiagnostic cognitive behavioural therapy for emotional disorders in primary care and its mechanisms of change: a randomized step-wedge clinical trial (PsicAP-CV) Open
Introduction Emotional disorders (ED) are highly prevalent worldwide. The PsicAP trial, conducted in Spain, demonstrated the benefits of adding transdiagnostic cognitive behavioural therapy (TD-CBT) to treatment as usual (TAU) for the atte…
View article: Enrollment of Females in Randomized Trials for Glucagon-Like Peptide 1 Receptor Agonists
Enrollment of Females in Randomized Trials for Glucagon-Like Peptide 1 Receptor Agonists Open
View article: Predictors of primary care psychological therapy outcomes for depression and anxiety in people living with dementia: evidence from national healthcare records in England
Predictors of primary care psychological therapy outcomes for depression and anxiety in people living with dementia: evidence from national healthcare records in England Open
Background Psychological therapies can be effective in reducing symptoms of depression and anxiety in people living with dementia (PLWD). However, factors associated with better therapy outcomes in PLWD are currently unknown. Aims To inves…
View article: Predictors of primary care psychological therapy outcomes for treatment of depression and anxiety in people living with dementia: evidence from national healthcare records in England
Predictors of primary care psychological therapy outcomes for treatment of depression and anxiety in people living with dementia: evidence from national healthcare records in England Open
Background Primary care psychological therapy services can be effective in reducing symptoms of depression and anxiety in people living with dementia (PLWD) and are recommended in national guidelines (e.g., NICE, UK). However, it is curren…
View article: APPLE‐Tree remote secondary dementia prevention; opportunities for scalable public health interventions to reduce dementia risk
APPLE‐Tree remote secondary dementia prevention; opportunities for scalable public health interventions to reduce dementia risk Open
Background Nearly half of people aged 60+ experience memory impairments that infer an increased risk of dementia. The UK APPLE‐Tree (Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to buil…
View article: Psychological therapies for depression and cardiovascular risk: evidence from national healthcare records in England
Psychological therapies for depression and cardiovascular risk: evidence from national healthcare records in England Open
Aims People with depression are up to 72% more at risk to develop cardiovascular disease (CVD) in their lifetime. Evidence-based psychotherapies are first-line interventions for the treatment of depression and are delivered nationally in E…
View article: Group cognitive stimulation therapy versus usual care for people with intellectual disabilities and dementia (CST-IDD) in the UK: protocol for a mixed-methods feasibility randomised controlled trial
Group cognitive stimulation therapy versus usual care for people with intellectual disabilities and dementia (CST-IDD) in the UK: protocol for a mixed-methods feasibility randomised controlled trial Open
Introduction The prevalence of dementia is almost five times higher in people with intellectual disabilities compared with the general population. However, evidence-based treatments for this population are lacking, as most randomised contr…
View article: Clinical outcomes and antibody transfer in a cohort of infants born to mothers with SARS-COV-2 infection during pregnancy (Coronascope Study)
Clinical outcomes and antibody transfer in a cohort of infants born to mothers with SARS-COV-2 infection during pregnancy (Coronascope Study) Open
Purpose: We aimed to describe the outcomes, focusing on the hearing and neurological development, of children born to mothers with SARS-CoV-2 infection during pregnancy, and to evaluate the persistence of maternal antibodies in the first m…
View article: Cognitive stimulation to improve cognitive functioning in people with dementia
Cognitive stimulation to improve cognitive functioning in people with dementia Open
In this updated review, now with a much more extensive evidence base, we have again identified small, short-term cognitive benefits for people with mild to moderate dementia participating in CS programmes. From a smaller number of studies,…
View article: Associations between psychological intervention for anxiety disorders and risk of dementia: a prospective cohort study using national health-care records data in England
Associations between psychological intervention for anxiety disorders and risk of dementia: a prospective cohort study using national health-care records data in England Open
View article: Effectiveness of primary care psychological therapy services for the treatment of depression and anxiety in people living with dementia: Evidence from national healthcare records in England
Effectiveness of primary care psychological therapy services for the treatment of depression and anxiety in people living with dementia: Evidence from national healthcare records in England Open
This work was supported by the Alzheimer's Society.
View article: Associations between psychological therapy outcomes for depression and incidence of dementia
Associations between psychological therapy outcomes for depression and incidence of dementia Open
Background Depression is an important, potentially modifiable dementia risk factor. However, it is not known whether effective treatment of depression through psychological therapies is associated with reduced dementia incidence. The aim o…
View article: Salivary cortisol in longitudinal associations between affective symptoms and midlife cognitive function: A British birth cohort study
Salivary cortisol in longitudinal associations between affective symptoms and midlife cognitive function: A British birth cohort study Open
View article: Understanding differences in mental health service use by men: an intersectional analysis of routine data
Understanding differences in mental health service use by men: an intersectional analysis of routine data Open
Purpose Rates of help-seeking for common mental health problems are lower for men, but less is known about patterns of engagement once they are in contact with services. Previous research has been limited in its ability to understand the i…
View article: Improving Access to Psychological Therapies in Spain: From IAPT to PsicAP
Improving Access to Psychological Therapies in Spain: From IAPT to PsicAP Open
This brief psychological treatment should be implemented in the Spanish public health system, similar to the precedent set by the IAPT initiative.
View article: Understanding the psychological therapy treatment outcomes for young adults who are not in education, employment, or training (NEET), moderators of outcomes, and what might be done to improve them
Understanding the psychological therapy treatment outcomes for young adults who are not in education, employment, or training (NEET), moderators of outcomes, and what might be done to improve them Open
Background To determine: whether young adults (aged 18–24) not in education, employment or training (NEET) have different psychological treatment outcomes to other young adults; any socio-demographic or treatment-related moderators of diff…
View article: The effect of remotely delivered lifestyle interventions on cognition in older adults without dementia: A systematic review and meta-analysis
The effect of remotely delivered lifestyle interventions on cognition in older adults without dementia: A systematic review and meta-analysis Open
View article: Mindfulness-based cognitive therapy for depression in people with dementia: A qualitative study on participant, carer and facilitator experiences
Mindfulness-based cognitive therapy for depression in people with dementia: A qualitative study on participant, carer and facilitator experiences Open
Background Depression in dementia is common and associated with negative health outcomes. Mindfulness-based cognitive therapy is a recommended treatment of choice for recurrent depression, but its use for depression in dementia is yet to b…
View article: Older adults respond better to psychological therapy than working-age adults: evidence from a large sample of mental health service attendees.
Older adults respond better to psychological therapy than working-age adults: evidence from a large sample of mental health service attendees. Open
View article: Social connectedness and dementia prevention: Pilot of the APPLE-Tree video-call intervention during the Covid-19 pandemic
Social connectedness and dementia prevention: Pilot of the APPLE-Tree video-call intervention during the Covid-19 pandemic Open
Background and Objectives The Covid-19 pandemic reduced access to social activities and routine health care that are central to dementia prevention. We developed a group-based, video-call, cognitive well-being intervention; and investigate…
View article: Cost-effectiveness of feedback-informed psychological treatment: Evidence from the IAPT-FIT trial
Cost-effectiveness of feedback-informed psychological treatment: Evidence from the IAPT-FIT trial Open
View article: Stakeholders’ views around the concept and diagnosis of mild cognitive impairment and their understanding of dementia prevention: A qualitative study
Stakeholders’ views around the concept and diagnosis of mild cognitive impairment and their understanding of dementia prevention: A qualitative study Open
Background Many people live with an awareness of mild cognitive changes and an associated dementia risk. Previous authors describe the uncertainties of this liminal state between cognitive health and dementia. The interface of this group w…
View article: Effectiveness of lifestyle and psychosocial interventions in reducing cognitive decline in older people: Systematic review
Effectiveness of lifestyle and psychosocial interventions in reducing cognitive decline in older people: Systematic review Open
Background Observational findings suggest that a third of dementia cases are attributable to modifiable risk factors (Livingston et al, 2017). However, we are still unclear on what non‐pharmacological interventions should look like or what…
View article: Cognitive Stimulation Therapy
Cognitive Stimulation Therapy Open
Cognitive stimulation therapy (CST) is a manualized psychosocial group intervention for people with mild to moderate dementia. Because of its broad scientific evidence and cost effectiveness, CST is now used globally. To ensure replicabili…
View article: “<i>Falling through the cracks</i>”; Stakeholders' views around the concept and diagnosis of mild cognitive impairment and their understanding of dementia prevention
“<i>Falling through the cracks</i>”; Stakeholders' views around the concept and diagnosis of mild cognitive impairment and their understanding of dementia prevention Open
Objectives Many people live with an awareness of mild cognitive changes that increase their dementia risk. Previous authors describe the uncertainties of this liminal state, between cognitive health and dementia, where being “at risk” can …