E. Klar
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View article: Von der Evidenz in die Versorgung: Chancen und Risiken für Gesundheits- und Wissenschaftspolitik. Ein Positionspapier der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF)
Von der Evidenz in die Versorgung: Chancen und Risiken für Gesundheits- und Wissenschaftspolitik. Ein Positionspapier der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) Open
Objective: After over 25 years of developing clinical practice guidelines, the Association of the Scientific Medical Societies in Germany (AWMF) held a symposium to discuss the following topics in order to improve the way evidence is imple…
View article: Effect of Early Removal of Urinary Catheter in Patients Undergoing Abdominal and Thoracic Surgeries with Continuous Thoracic Epidural Analgesia on Postoperative Urinary Retention
Effect of Early Removal of Urinary Catheter in Patients Undergoing Abdominal and Thoracic Surgeries with Continuous Thoracic Epidural Analgesia on Postoperative Urinary Retention Open
Background: Postoperative continuous thoracic epidural analgesia (TEA) is an integral aspect of pain management after major abdominal and thoracic surgery. Under TEA, postoperative urinary retention (POUR) is frequently noted, prompting a …
View article: Die EU-Verordnung für In-vitro-Diagnostika (IVDR) in der Praxis: Umsetzung und Anwendung – Ergebnisse einer öffentlichen Veranstaltung der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) im März 2023
Die EU-Verordnung für In-vitro-Diagnostika (IVDR) in der Praxis: Umsetzung und Anwendung – Ergebnisse einer öffentlichen Veranstaltung der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) im März 2023 Open
In order to discuss first experiences with the implementation of the EU Regulation on In Vitro Diagnostic Medical Devices (IVDR) about one year after its entry into force, the German Association of the Scientific Medical Societies (AWMF e.…
View article: Randomized Registry Trials - efficient post market clinical follow-up for medical devices
Randomized Registry Trials - efficient post market clinical follow-up for medical devices Open
In spite of advances in the treatment of cardiovascular disease, there remains a significant need for high-quality evidence for clinical practice given the rising prevalence worldwide. Next to the increase of regulatory requirements, poor …
View article: Die Medical Device Regulation nach Geltungsbeginn: Wie können Gestaltungsspielräume zur Praktikabilität genutzt werden?
Die Medical Device Regulation nach Geltungsbeginn: Wie können Gestaltungsspielräume zur Praktikabilität genutzt werden? Open
Ziel der Medical Device Regulation (MDR) ist die Erhöhung der Patientensicherheit mit Schutz vor Täuschung und Gefährdung. Der PIP-Skandal um Industriesilikon in Brustimplantaten 2012 war nicht der Auslöser, aber ein wesentlicher Katalysat…
View article: Conservative therapy of severe acute pancreatitis is a safe option – results of a 15-year long-term follow-up cohort study
Conservative therapy of severe acute pancreatitis is a safe option – results of a 15-year long-term follow-up cohort study Open
Background: Treatment of severe acute pancreatitis can be challenging with high mortality. In 2012 we reported a significantly reduced in-hospital mortality if these patients are treated conservatively for at least the first 3 weeks in the…
View article: Hydatid Disease of the Liver
Hydatid Disease of the Liver Open
Background: Echinococcosis also known as hydatid disease is a zoonotic parasitic disease caused by a tapeworm. It has a worldwide distribution. For long, it was thought to be a problem of the poorly sanitized “third world” an…
View article: Parasitic Disease of the Gastrointestinal Tract: Surgical Aspects
Parasitic Disease of the Gastrointestinal Tract: Surgical Aspects Open
View article: Acute Mesenteric Ischemia: Preexisting Comorbidity Determines Short-Term Outcome and Quality of Life in Long-Term Survivors
Acute Mesenteric Ischemia: Preexisting Comorbidity Determines Short-Term Outcome and Quality of Life in Long-Term Survivors Open
Introduction: Acute mesenteric ischemia (AMI), either arterial or venous, is still a devastating disease with poor prognosis. It is unknown, whether AMI is associated with impaired quality of life (QoL) in long-term survivors…
View article: Medical Device Regulation and current challenges for the implementation of new technologies
Medical Device Regulation and current challenges for the implementation of new technologies Open
The European Parliament and the European Council on May 26, 2017 decided to introduce the new regulatory framework for medical devices. The transitional period of the so called Medical Device Regulation (EU 2017/745, MDR) should end on May…
View article: Comparison Between Endoscopic Vacuum Therapy and Conventional Treatment for Leakage After Rectal Resection
Comparison Between Endoscopic Vacuum Therapy and Conventional Treatment for Leakage After Rectal Resection Open
Background Anastomotic leakage after rectal resection represents a severe complication for the patient and requires an early and appropriate management. Endoscopic vacuum therapy (EVT) has become the treatment of choice for anastomotic lea…
View article: Acute Mesenteric Ischemia
Acute Mesenteric Ischemia Open
Background: Despite constant improvements in diagnostic as well as interventional and surgical techniques, acute mesenteric ischemia (AMI) remains a life-threatening emergency with high mortality rates. The time to diagnosis …
View article: Rare cause of upper gastrointestinal bleeding due to primary aortoesophageal fistula - a case report
Rare cause of upper gastrointestinal bleeding due to primary aortoesophageal fistula - a case report Open
Background: The incidence of acute upper gastrointestinal bleeding (UGIB) has declined over the recent decades, and nowadays, due to improved endoscopic treatment options, only 2.6% of the patients with UGIB need additional surgical or ang…
View article: Quality of Life after Complex Abdominal Wall Reconstruction
Quality of Life after Complex Abdominal Wall Reconstruction Open
Background: Component separation (CS) for tension-free approximation of fascial edges is the established technique for the repair of large ventral hernias mostly regarding midline defects. Recent studies suggest lower complic…
View article: Integrated Biobanking and Tumor Model Establishment of Human Colorectal Carcinoma Provides Excellent Tools for Preclinical Research
Integrated Biobanking and Tumor Model Establishment of Human Colorectal Carcinoma Provides Excellent Tools for Preclinical Research Open
Over the time period from 2006 to 2017, consecutive patients operated on at the University Medical Center Rostock participated in the comprehensive biobanking and tumor-modelling approach known as the HROC collection. Samples were collecte…
View article: No need for surgery? Patterns and outcomes of blunt abdominal trauma
No need for surgery? Patterns and outcomes of blunt abdominal trauma Open
Introduction The management of a patient suffering from blunt abdominal trauma (BAT) remains a challenge for the emergency physician. Within the last few years, the standard therapy for hemodynamically stable patients with BAT has transiti…
View article: HEGPOL: Randomized, placebo controlled, multicenter, double-blind clinical trial to investigate hepatoprotective effects of glycine in the postoperative phase of liver transplantation [ISRCTN69350312]
HEGPOL: Randomized, placebo controlled, multicenter, double-blind clinical trial to investigate hepatoprotective effects of glycine in the postoperative phase of liver transplantation [ISRCTN69350312] Open
Background Kupffer cell-dependent ischemia / reperfusion (I/R) injury after liver transplantation is still of high clinical relevance, as it is strongly associated with primary dysfunction and primary nonfunction of the graft. Glycine, a n…
View article: Targeting Immune-Related Molecules in Cancer Therapy: A Comprehensive<i>In Vitro</i>Analysis on Patient-Derived Tumor Models
Targeting Immune-Related Molecules in Cancer Therapy: A Comprehensive<i>In Vitro</i>Analysis on Patient-Derived Tumor Models Open
This study investigated the impact of immune-related pathway inhibition, among them indolamine 2,3-dioxygenase (IDO), alone and together with immune cells on growth and viability of colorectal cancer (CRC) cells. A panel of patient-derived…
View article: Neoadjuvant radio-chemotherapy prolongs healing of anastomotic leakage after rectal resection treated with endoscopic vacuum therapy
Neoadjuvant radio-chemotherapy prolongs healing of anastomotic leakage after rectal resection treated with endoscopic vacuum therapy Open
Background: Neoadjuvant radiochemotherapy (nRCT) is an important component in the treatment of advanced rectal cancer. Endoscopic vacuum therapy (EVT) has become the treatment of choice for anastomotic leakage after rectal resection in man…
View article: Villus Growth, Increased Intestinal Epithelial Sodium Selectivity, and Hyperaldosteronism Are Mechanisms of Adaptation in a Murine Model of Short Bowel Syndrome
Villus Growth, Increased Intestinal Epithelial Sodium Selectivity, and Hyperaldosteronism Are Mechanisms of Adaptation in a Murine Model of Short Bowel Syndrome Open
View article: Establishment, functional and genetic characterization of three novel patient-derived rectal cancer cell lines
Establishment, functional and genetic characterization of three novel patient-derived rectal cancer cell lines Open
These newly established and in-depth characterized ultra-low passage rectal cancer cell lines provide a useful instrument for analysis of biological characteristics of rectal cancer.
View article: Establishment, functional and genetic characterization of a colon derived large cell neuroendocrine carcinoma cell line
Establishment, functional and genetic characterization of a colon derived large cell neuroendocrine carcinoma cell line Open
We successfully established and characterized a novel patient-derived NEC cell line in parallel to a PDX model as a useful tool for further analysis of the biological characteristics and for development of novel diagnostic and therapeutic …
View article: High compliance with guideline recommendations but low completion rates of adjuvant chemotherapy in resected pancreatic cancer: A cohort study
High compliance with guideline recommendations but low completion rates of adjuvant chemotherapy in resected pancreatic cancer: A cohort study Open
Our results indicate a high acceptance of the S3-guidline recommendation for adCx in resected PDAC in a routine setting, which, however, is completed in only 50% of all patients. Fully completed adCx had the most powerful effect on improvi…
View article: Murine Endogenous Retroviruses Are Detectable in Patient-Derived Xenografts but Not in Patient-Individual Cell Lines of Human Colorectal Cancer
Murine Endogenous Retroviruses Are Detectable in Patient-Derived Xenografts but Not in Patient-Individual Cell Lines of Human Colorectal Cancer Open
Endogenous retroviruses are remnants of retroviral infections. In contrast to their human counterparts, murine endogenous retroviruses (mERV) still can synthesize infectious particles and retrotranspose. Xenotransplanted human cells have o…
View article: Before and after Anorectal Surgery: Which Information Is Needed from the Functional Laboratory
Before and after Anorectal Surgery: Which Information Is Needed from the Functional Laboratory Open
Background: Anorectal surgery covers a wide spectrum of surgery. Diagnostic workup of anorectal disease is based on clinical examination with basic functional tests followed by more elaborate diagnostic tests. Since the incid…
View article: The Ongoing Challenge of Acute Mesenteric Ischemia
The Ongoing Challenge of Acute Mesenteric Ischemia Open
Background: The lethality of acute mesenteric ischemia (AMI) remains quite high with 50-70%. The main reasons for that are the fact that AMI is rarely taken into consideration by the differential diagnosis of acute abdomen, the time-consum…
View article: Professor Joachim Mössner Retires as Editor-in-Chief
Professor Joachim Mössner Retires as Editor-in-Chief Open
View article: Oligometastases of Gastrointestinal Cancer Origin
Oligometastases of Gastrointestinal Cancer Origin Open
View article: PharmaNews
PharmaNews Open
View article: PharmaForum
PharmaForum Open