Erin Boland
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View article: Mechanical de-skewing enables high-resolution imaging of thin tissue slices with a mesoSPIM light-sheet microscope
Mechanical de-skewing enables high-resolution imaging of thin tissue slices with a mesoSPIM light-sheet microscope Open
Optical clearing combined with light-sheet microscopy enables high-resolution imaging of extended tissue at scale. However, standard mesoSPIM systems are optimised for intact organs and are not suited to thin tissue slices. We present a no…
View article: Biomechanical and compositional basement membrane defects due to a Col4a1 mutation affect cardiac morphology and function
Biomechanical and compositional basement membrane defects due to a Col4a1 mutation affect cardiac morphology and function Open
Collagen IV is a major constituent of basement membranes and mutations in the genes COL4A1 and COL4A2 present clinically as a variable, multi-system disorder called COL4A1 (Gould) syndrome. Evidence from case reports supports a cardiac com…
View article: Cerebral small vessel disease due to <i>Col4a1</i> mutations include cognitive impairment and white matter defects that can be modulated by targeting protein folding
Cerebral small vessel disease due to <i>Col4a1</i> mutations include cognitive impairment and white matter defects that can be modulated by targeting protein folding Open
White matter abnormalities are a hallmark of cerebral small vessel disease (cSVD) and are closely linked to cognitive decline and dementia. However, despite their clinical importance, underlying mechanisms remain poorly understood. Collage…
View article: SENSE-Cog Residential Care: hearing and vision support for residents with dementia in long-term care in Ireland—protocol for a pilot cluster-randomised controlled trial
SENSE-Cog Residential Care: hearing and vision support for residents with dementia in long-term care in Ireland—protocol for a pilot cluster-randomised controlled trial Open
ISRCTN, ISRCTN14462472. Registered 24 February 2022, https://doi.org/10.1186/ISRCTN14462472.
View article: Through Their Eyes: Defining ‘good life’ in dementia for health economics and outcomes research
Through Their Eyes: Defining ‘good life’ in dementia for health economics and outcomes research Open
Despite progress in involving people living with dementia in health research, disparities remain, particularly in the field of health economics and outcomes research, where excessive reliance on proxy reports from care partners or healthca…
View article: Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage
Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage Open
View article: An investigation of sleep problems, gastrointestinal symptoms, comorbid psychopathology and challenging behavior in children and adolescents with Down Syndrome
An investigation of sleep problems, gastrointestinal symptoms, comorbid psychopathology and challenging behavior in children and adolescents with Down Syndrome Open
Findings indicated a high frequency of sleep problems, comorbid psychopathology, GI symptoms, and challenging behavior and demonstrated a relationship between GI symptoms and self-injurious behavior in children and adolescents with DS. Thi…
View article: A novel method for the percutaneous induction of myocardial infarction by occlusion of small coronary arteries in the rabbit
A novel method for the percutaneous induction of myocardial infarction by occlusion of small coronary arteries in the rabbit Open
Surgical coronary ligation is the standard technique to induce myocardial infarction (MI) in rabbits but is associated with procedural trauma and the generation of thoracic adhesions. Percutaneous coronary occlusion avoids these shortcomin…
View article: The high cost of care and limited evidence on cost-effective strategies for Lewy body dementia: systematic review of evidence
The high cost of care and limited evidence on cost-effective strategies for Lewy body dementia: systematic review of evidence Open
Background Lewy body dementia (LBD) is a prevalent yet frequently underdiagnosed form of dementia, accounting for up to 15% of all dementia cases. Aims This study aims to increase awareness and advocacy for LBD by gathering and critically …
View article: Percutaneous myocardial infarction model in rabbit v1
Percutaneous myocardial infarction model in rabbit v1 Open
This video file contains fluoroscopic recordings of 6 steps of the percutaneous inductions of myocardial infarction in rabbit. 1. Identification of the aortic structures. 2. Insertion of the guide wire. 3. Guidance of 4F catheter over guid…
View article: SENSE-Cog Residential Care: Hearing and vision support for residents with dementia in long-term care in Ireland: Protocol for a pilot cluster randomised controlled trial
SENSE-Cog Residential Care: Hearing and vision support for residents with dementia in long-term care in Ireland: Protocol for a pilot cluster randomised controlled trial Open
Background Hearing and vision loss is highly prevalent in residents with dementia (RwD) living in long-term care (LTC) facilities. Sensory loss often has a negative impact on quality of life and other dementia-related outcomes. Optimising …
View article: A novel binary pesticidal protein from Chryseobacterium arthrosphaerae controls western corn rootworm by a different mode of action to existing commercial pesticidal proteins
A novel binary pesticidal protein from Chryseobacterium arthrosphaerae controls western corn rootworm by a different mode of action to existing commercial pesticidal proteins Open
The western corn rootworm (WCR) Diabrotica virgifera virgifera (Coleoptera: Chrysomelidae) remains one of the economically most important pests of maize ( Zea mays ) due to its adaptive capabilities to pest management options. This include…
View article: The role of basement membranes in cardiac biology and disease
The role of basement membranes in cardiac biology and disease Open
Basement membranes (BMs) are highly specialised extracellular matrix (ECM) structures that within the heart underlie endothelial cells (ECs) and surround cardiomyocytes and vascular smooth muscle cells. They generate a dynamic and structur…
View article: Definition of Treatment-Resistant Depression in the Medicare Population
Definition of Treatment-Resistant Depression in the Medicare Population Open
View article: Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Women
Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Women Open
Hormone therapy for the primary prevention of chronic conditions in menopausal women is associated with some beneficial effects but also with a substantial increase of risks for harms. The available evidence regarding benefits and harms of…
View article: Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Women: Evidence Report and Systematic Review for the US Preventive Services Task Force
Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Women: Evidence Report and Systematic Review for the US Preventive Services Task Force Open
Importance: Postmenopausal status coincides with increased risks for chronic conditions such as heart disease, osteoporosis, cognitive impairment, or some types of cancers. Previously, hormone therapy was used for the primary prevention of…
View article: Primary Care Screening and Treatment for Latent Tuberculosis Infection in Adults: Evidence Report and Systematic Review for the US Preventive Services Task Force
Primary Care Screening and Treatment for Latent Tuberculosis Infection in Adults: Evidence Report and Systematic Review for the US Preventive Services Task Force Open
Five to ten percent of individuals with latent tuberculosis infection (LTBI) progress to active tuberculosis (TB) disease. Identifying and treating LTBI is a key component of the strategy for reducing the burden of TB disease. To review th…
View article: Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: systematic review and meta-analysis
Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: systematic review and meta-analysis Open
Second generation antidepressants and CBT have evidence bases of benefits and harms in major depressive disorder. Available evidence suggests no difference in treatment effects of second generation antidepressants and CBT, either alone or …
View article: Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: systematic review and meta-analysis
Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: systematic review and meta-analysis Open
Study question What are the benefits and harms of second generation antidepressants and cognitive behavioral therapies (CBTs) in the initial treatment of a current episode of major depressive disorder in adults?Methods This was a systemati…