Erin C. Dunn
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View article: A methylome-wide association study of major depression with out-of-sample case–control classification and trans-ancestry comparison
A methylome-wide association study of major depression with out-of-sample case–control classification and trans-ancestry comparison Open
Major depression (MD) is a leading cause of global disease burden, and both experimental and population-based studies suggest that differences in DNA methylation may be associated with the condition. However, previous DNA methylation studi…
View article: Associations between epigenetic age and brain age in young people
Associations between epigenetic age and brain age in young people Open
Recent research suggests biological age, based on epigenetic or neuroimaging measures, may predict health traits in adulthood more accurately than chronological age. However, it is unclear if these findings apply earlier in life. We aimed …
View article: Latent Class Analysis of Household and Community Adversity Among Pre-Adolescent Youth in the United States
Latent Class Analysis of Household and Community Adversity Among Pre-Adolescent Youth in the United States Open
The purpose of this study was to: 1) examine the co-occurrence of household and community adverse childhood experiences (ACEs) among preadolescent youth using latent class analysis (LCA), and 2) examine the association of ACE latent cluste…
View article: Home and epigenome: exploring the role of DNA methylation in the relationship between poor housing quality and depressive symptoms
Home and epigenome: exploring the role of DNA methylation in the relationship between poor housing quality and depressive symptoms Open
Introduction Poor housing quality associates with risk for depression. However, previous research often lacks consideration of socioeconomic status (SES) baseline depressive symptoms and biological processes, leading to concerns of confoun…
View article: Type and developmental timing of childhood adversity predicts psychopathology symptoms in a South African birth cohort
Type and developmental timing of childhood adversity predicts psychopathology symptoms in a South African birth cohort Open
Background Childhood adversity is widespread globally and is one of the strongest predictors of later psychopathology. However, the differential effects of type and timing of childhood adversities on childhood psychopathology remain unclea…
View article: Inter-rater reliability of stress signatures in exfoliated primary dentition - Improving scientific rigor and reproducibility in histological data collection
Inter-rater reliability of stress signatures in exfoliated primary dentition - Improving scientific rigor and reproducibility in histological data collection Open
Accentuated Lines (ALs) in tooth enamel can reflect metabolic disruptions from physiological or psychological stresses during development. They can therefore serve as a retrospective biomarker of generalized stress exposure in archaeologic…
View article: Brain health Begins Before Birth (B4): A “learning” pregnancy and birth cohort study
Brain health Begins Before Birth (B4): A “learning” pregnancy and birth cohort study Open
Mental health disorders affect over 1 billion people worldwide, profoundly impacting individuals, families, and the global economy. Risk for psychopathology begins early in life, with the perinatal period representing a critical window of …
View article: Sensitive periods for exposure to indoor air pollutants and psychosocial factors in association with symptoms of psychopathology at school-age in a South African birth cohort
Sensitive periods for exposure to indoor air pollutants and psychosocial factors in association with symptoms of psychopathology at school-age in a South African birth cohort Open
Exposure to environmental toxicants and psychosocial stressors during gestation and early life are particularly harmful and may impact brain development. Specifically, exposure to indoor air pollutants (IAP) and psychosocial factors (PF) d…
View article: Stress reactivity moderates the association between stressful life events and depressive symptoms in adolescents: Results from a population-based study
Stress reactivity moderates the association between stressful life events and depressive symptoms in adolescents: Results from a population-based study Open
When resources are limited, interventions should prioritise individuals with high stress reactivity who have experienced multiple stressful life events, as these individuals may be at greater risk for depression.
View article: Maximizing insights from longitudinal epigenetic age data: simulations, applications, and practical guidance
Maximizing insights from longitudinal epigenetic age data: simulations, applications, and practical guidance Open
Background Epigenetic age (EA) is an age estimate, developed using DNA methylation (DNAm) states of selected CpG sites across the genome. Although EA and chronological age are highly correlated, EA may not increase uniformly with time. Dep…
View article: Environmental impact, cost, and acceptability of a laboratory sustainability certification program for biomedical research in an academic medical center
Environmental impact, cost, and acceptability of a laboratory sustainability certification program for biomedical research in an academic medical center Open
Introduction: The healthcare sector contributes considerably to greenhouse gas emissions in the U.S. Biomedical research within academic medical centers (AMCs) is particularly energy- and resource-intensive. This study sought to assess the…
View article: Developmental Timing of Associations Among Parenting, Brain Architecture, and Mental Health
Developmental Timing of Associations Among Parenting, Brain Architecture, and Mental Health Open
Importance Parenting is associated with brain development and long-term health outcomes, although whether these associations depend on the developmental timing of exposure remains understudied. Identifying these sensitive periods can infor…
View article: Home and Epigenome: DNA Methylation as a Link Between Poor Housing Quality and Depressive Symptoms
Home and Epigenome: DNA Methylation as a Link Between Poor Housing Quality and Depressive Symptoms Open
Poor housing quality associates with risk for depression. However, previous research often lacks consideration of socioeconomic status (SES) baseline depressive symptoms and biological processes, leading to concerns of confounding and reve…
View article: Maximizing Insights from Longitudinal Epigenetic Age Data: Simulations, Applications, and Practical Guidance
Maximizing Insights from Longitudinal Epigenetic Age Data: Simulations, Applications, and Practical Guidance Open
Background Epigenetic Age (EA) is an age estimate, developed using DNA methylation (DNAm) states of selected CpG sites across the genome. Although EA and chronological age are highly correlated, EA may not increase uniformly with time. Dep…
View article: Depressive symptoms in adolescence and adult educational and employment outcomes: a structured life course analysis
Depressive symptoms in adolescence and adult educational and employment outcomes: a structured life course analysis Open
Background Depression is a common mental health disorder that often starts during adolescence, with potentially important future consequences including ‘Not in Education, Employment or Training’ (NEET) status. Methods We took a structured …
View article: The Prevalence, Predictors, and Health Consequences of Disagreement in Reports of Child Maltreatment Exposure
The Prevalence, Predictors, and Health Consequences of Disagreement in Reports of Child Maltreatment Exposure Open
The purpose of this study was to examine the prevalence, predictors, and consequences of disagreement between prospective caregiver and retrospective child reports of childhood physical and emotional maltreatment. The design was a secondar…
View article: DNA methylation as a possible mechanism linking childhood adversity and health: results from a 2-sample mendelian randomization study
DNA methylation as a possible mechanism linking childhood adversity and health: results from a 2-sample mendelian randomization study Open
Childhood adversity is an important risk factor for adverse health across the life course. Epigenetic modifications, such as DNA methylation (DNAm), are a hypothesized mechanism linking adversity to disease susceptibility. Yet, few studies…
View article: Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference Open
Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to …
View article: A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparison
A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparison Open
Major Depression (MD) is a leading cause of global disease burden, and both experimental and population-based studies suggest that differences in DNA methylation (DNAm) may be associated with the condition. However, previous DNAm studies h…
View article: An Industry Proposal for a Cell and Gene Therapy Safety Data Sheet
An Industry Proposal for a Cell and Gene Therapy Safety Data Sheet Open
This initial CGT SDS communicates workplace hazards and assesses the unique risks posed by these biological materials and can assist in creating exposure control plans specific to the workplace hazards.
View article: Sensitive periods for exposure to indoor air pollutants and psychosocial factors in association with symptoms of psychopathology at school-age in a South African birth cohort
Sensitive periods for exposure to indoor air pollutants and psychosocial factors in association with symptoms of psychopathology at school-age in a South African birth cohort Open
Background Gestation and the first few months of life are important periods for brain development. During these periods, exposure to environmental toxicants and psychosocial stressors are particularly harmful and may impact brain developme…