Explanipedia

Utility of transepidermal water loss‐stratum corneum hydration ratio in atopic dermatitis Open

Shreya Sreekantaswamy, Jason M. Meyer, Erin E. Grinich, Yael A. Leshem, Eric L. Simpson , et al. · 2024

The epidermis plays a key role in maintaining homeostasis via its regulation of water loss through the skin. Epidermal water barrier and binding characteristics are typically assessed via transepidermal water loss (TEWL) and stratum corneu…

Topical steroid withdrawal treated with ruxolitinib cream Open

M. Shea, Erin E. Grinich, Eric L. Simpson · 2024

Factors Associated with Eczema Clinical Trial Awareness, Interest, and Participation in Adults Open

Erin E. Grinich, Isabelle J. Thibau, Emile Latour, Kyla N. Price, Allison R. Loiselle , et al. · 2023

Despite the need for improved eczema therapies and a rapid increase in available eczema clinical trials, participation remains low. The aim of this study was to identify factors associated with clinical trial awareness, interest, and barri…

Measuring Atopic Eczema Control and Itch Intensity in Clinical Practice Open

Yael A. Leshem, Joanne R Chalmers, Christian Apfelbacher, Norito Katoh, Louise A. A. Gerbens , et al. · 2022

Importance Measuring outcomes in clinical practice can aid patient care, quality improvement, and real-world evidence generation. The Harmonising Outcome Measures for Eczema (HOME) Clinical Practice initiative is developing a list of valid…

The Eczema Area and Severity Index—A Practical Guide Open

Jon M. Hanifin, Wenelia Baghoomian, Erin E. Grinich, Yael A. Leshem, M. E. Jacobson , et al. · 2022

Atopic dermatitis is a chronic inflammatory skin condition that affects approximately 18 million people in the United States. Assessing the extent and severity of atopic dermatitis is critical for determining baseline disease burden and tr…

Measurement properties of patient‐reported outcome measures for eczema control: a systematic review Open

Beth Stuart, Laura Howells, Rachael Pattinson, Joanne R Chalmers, D. J. C. Grindlay , et al. · 2021

Atopic eczema (herein referred to as ‘eczema’) is a skin disease characterized by remitting and relapsing symptoms. The Harmonising Outcome Measures for Eczema (HOME) initiative was developed to establish a core outcome set (COS) for eczem…

Recommended core outcome instruments for health‐related quality of life, long‐term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting* Open

Kim S Thomas, Christian Apfelbacher, Joanne R Chalmers, Eric L. Simpson, Phyllis I. Spuls , et al. · 2021

For now, the core outcome set for clinical trials in AE is complete. The specified domains and instruments should be used in all new clinical trials and systematic reviews of eczema treatments.

Recommended core outcome instruments for health‐related quality of life, long‐term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting Open

Kim S Thomas, Christian Apfelbacher, Joanne R Chalmers, Eric L. Simpson, Phyllis I. Spuls , et al. · 2020

For now, the core outcome set for clinical trials in atopic eczema is complete. The specified domains and instruments should be used in all new clinical trials and systematic reviews of eczema treatments.

557 Patient-reported disease trajectory for adults with atopic dermatitis- A pilot study Open

Erin E. Grinich, Janice Chung, Christina Topham, Eric L. Simpson · 2019

Standardized reporting of the Eczema Area and Severity Index (EASI) and the Patient-Oriented Eczema Measure (POEM): a recommendation by the Harmonising Outcome Measures for Eczema (HOME) Initiative Open

Erin E. Grinich, Jochen Schmitt, Denise Küster, Phyllis I. Spuls, Hywel C Williams , et al. · 2018

Several organizations from multiple fields of medicine are setting standards for clinical research including protocol development,1 harmonization of outcome reporting,2 statistical analysis,3 quality assessment4 and reporting of findings.1…

686 The validity of a novel patient-operated device for measuring skin barrier function Open

Erin E. Grinich, Anuja V. Shah, Eric L. Simpson · 2018

Subcutaneous panniculitis-like T-cell lymphoma responsive to combination therapy with methotrexate and corticosteroids Open

Erin E. Grinich, Stephanie Mengden Koon, Michael J. Cascio, Nicole Fett · 2018

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare condition that falls underneath the umbrella of primary cutaneous T-cell lymphomas (CTCLs). SPTCL can be very difficult to diagnose as it may mimic other subtypes of CTCL, su…

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