Eddie Jones
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View article: Assessing healthcare resource utilization burden and unmet treatment needs in patients with Parkinson’s disease: results from a real-world study
Assessing healthcare resource utilization burden and unmet treatment needs in patients with Parkinson’s disease: results from a real-world study Open
Aim: Current Parkinson’s disease (PD) research evaluates patients with early and severe PD, but often overlooks patients with intermediate PD. This study aims to quantify unmet treatment needs, disease burden and healthcare resource utiliz…
View article: Association Between Tremor Severity and Caregiving Intensity in Essential Tremor
Association Between Tremor Severity and Caregiving Intensity in Essential Tremor Open
Background: Essential tremor (ET) is a common movement disorder that affects the upper limbs in vital activities of daily living. Few studies have examined the impact of tremor severity on caregiving intensity. Methods: Clinic-based data w…
View article: Work and Activity Impairment in Individuals with Essential Tremor
Work and Activity Impairment in Individuals with Essential Tremor Open
Work impairment is significantly correlated with tremor severity. Although a minority of patients in this clinic-based cohort were identified as employed, nearly all reported a negative impact on work performance.
View article: MRI versus relapse: optimal activity monitoring for management of progressive multiple sclerosis
MRI versus relapse: optimal activity monitoring for management of progressive multiple sclerosis Open
Secondary progressive multiple sclerosis is often categorized as ‘active’/‘non-active’ based on inflammatory activity on MRI, or relapse; however, the value of MRI/relapse as indicators of disease activity in real-world and clinical trial …
View article: Real‐world analysis of the clinical care pathway of patients living with Alzheimer’s disease in the United States according to stage of cognitive impairment at diagnosis
Real‐world analysis of the clinical care pathway of patients living with Alzheimer’s disease in the United States according to stage of cognitive impairment at diagnosis Open
Background We analyzed the clinical care pathway of patients from symptom development to diagnosis at varying stages of Alzheimer’s disease (AD) to understand the path and barriers to diagnosis. Methods Data were from the US Adelphi Real W…
View article: O045 Repetitive transcranial magnetic stimulation improves sleep in children with autism spectrum disorder
O045 Repetitive transcranial magnetic stimulation improves sleep in children with autism spectrum disorder Open
Introduction There are no controlled studies examining the impact of repetitive transcranial magnetic stimulation (α-rTMS) on sleep difficulties in children with autism spectrum disorder (ASD). Method Twenty children (6-12yrs old; 16 males…
View article: Healthcare resource utilization and economic burden of multiple sclerosis in Chinese patients: results from a real-world survey
Healthcare resource utilization and economic burden of multiple sclerosis in Chinese patients: results from a real-world survey Open
Multiple sclerosis (MS) is uncommon in China and the standard of care is underdeveloped, with limited utilization of disease-modifying treatment (DMT). An understanding of real-world disease burden (including direct medical, non-medical, a…
View article: Associations Among Tremor Amplitude, Activities of Daily Living, and Quality of Life in Patients with Essential Tremor
Associations Among Tremor Amplitude, Activities of Daily Living, and Quality of Life in Patients with Essential Tremor Open
Background: Essential tremor (ET) is a disabling syndrome consisting of tremor, primarily in the upper limbs. We assessed the correlation of The Essential Tremor Rating Assessment Scale (TETRAS) Performance Item 4 ratings of upper limb tre…
View article: The presence and burden of cognitive issues: discordance between the perception of neurologists and people living with multiple sclerosis
The presence and burden of cognitive issues: discordance between the perception of neurologists and people living with multiple sclerosis Open
Background and purpose Cognitive impairment is a common symptom of multiple sclerosis (MS) and occurs in more than 40% of people living with MS (plwMS). No real‐world study has assessed the perception of neurologists and plwMS on cognitive…
View article: Shared Decision-Making in the Treatment of Multiple Sclerosis: Results of a Cross-Sectional, Real-World Survey in Europe and the United States
Shared Decision-Making in the Treatment of Multiple Sclerosis: Results of a Cross-Sectional, Real-World Survey in Europe and the United States Open
Patients who have an active role in treatment decision-making show improved wellbeing and QoL, and overall treatment satisfaction.
View article: The Impact of Agitation in Dementia on Caregivers: A Real-World Survey
The Impact of Agitation in Dementia on Caregivers: A Real-World Survey Open
Background: Dementia patients frequently depend on caregivers. Agitation is a common behavioral dementia symptom particularly burdensome to patients and caregivers. Objective: To assess the association of agitation severity with non-profes…
View article: Agitation in Dementia: Real-World Impact and Burden on Patients and the Healthcare System
Agitation in Dementia: Real-World Impact and Burden on Patients and the Healthcare System Open
Background: At least 90%of patients with dementia experience behavioral or neuropsychiatric symptoms including agitation, psychotic symptoms, apathy, depression, and sleep disturbances. Agitation has been reported to be experienced by 60%o…
View article: Impact of Dementia-Related Behavioral Symptoms on Healthcare Resource Use and Caregiver Burden: Real-World Data from Europe and the United States
Impact of Dementia-Related Behavioral Symptoms on Healthcare Resource Use and Caregiver Burden: Real-World Data from Europe and the United States Open
Background: Dementia is commonly accompanied by neurobehavioral symptoms; however, the relationship between such symptoms and health-related outcomes is unclear. Objective: To investigate the impact of specific neurobehavioral symptoms in …
View article: Real-world assessment of “OFF” episode–related healthcare resource utilization among patients with Parkinson’s disease in the United States
Real-world assessment of “OFF” episode–related healthcare resource utilization among patients with Parkinson’s disease in the United States Open
Patients with PD and "OFF" episodes had higher HCRU and costs than those without "OFF," suggesting that "OFF" episodes contribute to the economic burden of PD. Further research is warranted to examine the extent that current PD treatments …
View article: Work Productivity Outcomes Associated with Ocrelizumab Compared with Other Disease-Modifying Therapies for Multiple Sclerosis
Work Productivity Outcomes Associated with Ocrelizumab Compared with Other Disease-Modifying Therapies for Multiple Sclerosis Open
This real-world evidence suggests that patients with MS treated with OCR experience lower work and activity impairment than patients treated with other DMTs.
View article: A Novel, Integrative Approach for Evaluating Progression in Multiple Sclerosis: Development of a Scoring Algorithm
A Novel, Integrative Approach for Evaluating Progression in Multiple Sclerosis: Development of a Scoring Algorithm Open
Background There is an unmet need for a tool that helps to evaluate patients who are at risk of progressing from relapsing-remitting multiple sclerosis to secondary progressive multiple sclerosis (SPMS). A new tool supporting the evaluatio…
View article: Quantifying the diagnostic pathway for patients with cognitive impairment: real-world data from Australia
Quantifying the diagnostic pathway for patients with cognitive impairment: real-world data from Australia Open
A substantial number of Australians experience cognitive decline and behavioral changes some time before consulting a physician or being diagnosed with dementia. Increasing public awareness of the importance of early diagnosis is essential…
View article: A mixed methods approach towards understanding key disease characteristics associated with the progression from RRMS to SPMS: Physicians’ and patients’ views
A mixed methods approach towards understanding key disease characteristics associated with the progression from RRMS to SPMS: Physicians’ and patients’ views Open
This was the first stage of development of a novel, validated, physician-completed tool to support physician-patient interactions in evaluating signs indicative of disease progression to SPMS. Qualitative and quantitative methods (involvin…
View article: P1‐295: BEHAVIORAL SYMPTOMS AND DISTURBANCES IN DEMENTIA: A HIGHLY PREVALENT CONDITION
P1‐295: BEHAVIORAL SYMPTOMS AND DISTURBANCES IN DEMENTIA: A HIGHLY PREVALENT CONDITION Open
Behavioral and neuropsychiatric symptoms including agitation, aggression and sleep disturbances, are a common and potentially severe problem complicating dementia. Relatively few data on type and frequency of behavioral disturbances (BD) e…
View article: Non-professional caregiver burden is associated with the severity of patients’ cognitive impairment
Non-professional caregiver burden is associated with the severity of patients’ cognitive impairment Open
This study of real-world data confirmed an association between increased caregiver burden and severity of patients' cognitive impairment by analysis of a wide range of validated measures of caregiver burden. These findings suggest that mai…