Erin K. Stenson
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View article: Urine Complement Factor Ba Identifies Persistent Acute Kidney Injury and Organ Failures in Critically Ill Adults
Urine Complement Factor Ba Identifies Persistent Acute Kidney Injury and Organ Failures in Critically Ill Adults Open
Urine Ba is increased in patients with severe AKI and discriminates between patients who have AKI recovery and patients who develop persistent AKI. A doubling of urine Ba was associated with a 6.6-fold increased odds of persistent AKI. Fut…
View article: The Association Between Vasopressin and Adverse Kidney Outcomes in Children and Young Adults Requiring Vasopressors on Continuous Renal Replacement Therapy
The Association Between Vasopressin and Adverse Kidney Outcomes in Children and Young Adults Requiring Vasopressors on Continuous Renal Replacement Therapy Open
OBJECTIVES: Continuous renal replacement therapy (CRRT) and shock are both associated with high morbidity and mortality in the ICU. Adult data suggest renoprotective effects of vasopressin vs. catecholamines (norepinephrine and epinephrine…
View article: Assessing Cognition in CKD Using the National Institutes of Health Toolbox
Assessing Cognition in CKD Using the National Institutes of Health Toolbox Open
Key Points Participants with CKD had detectable cognitive deficits in fluid cognition, dexterity, and total cognition. Sex differences in cognition exist in people with CKD. Background CKD is largely an age-related clinical disorder with a…
View article: Factors associated with successful liberation from continuous renal replacement therapy in children and young adults: analysis of the worldwide exploration of renal replacement outcomes collaborative in Kidney Disease Registry
Factors associated with successful liberation from continuous renal replacement therapy in children and young adults: analysis of the worldwide exploration of renal replacement outcomes collaborative in Kidney Disease Registry Open
View article: Major Adverse Kidney Events in Pediatric Continuous Kidney Replacement Therapy
Major Adverse Kidney Events in Pediatric Continuous Kidney Replacement Therapy Open
Importance Continuous kidney replacement therapy (CKRT) is increasingly used in youths with critical illness, but little is known about longer-term outcomes, such as persistent kidney dysfunction, continued need for dialysis, or death. Obj…
View article: Continuous Kidney Replacement Therapy and Survival in Children and Young Adults: Findings From the Multinational WE-ROCK Collaborative
Continuous Kidney Replacement Therapy and Survival in Children and Young Adults: Findings From the Multinational WE-ROCK Collaborative Open
View article: Time to Continuous Renal Replacement Therapy Initiation and 90-Day Major Adverse Kidney Events in Children and Young Adults
Time to Continuous Renal Replacement Therapy Initiation and 90-Day Major Adverse Kidney Events in Children and Young Adults Open
Importance In clinical trials, the early or accelerated continuous renal replacement therapy (CRRT) initiation strategy among adults with acute kidney injury or volume overload has not demonstrated a survival benefit. Whether the timing of…
View article: Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK)
Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK) Open
The retrospective WE-ROCK study represents the largest international registry of children receiving CRRT for AKI or FO. It will serve as a broad and invaluable resource for the field of pediatric critical care nephrology that will improve …
View article: Fluid Balance and Its Association With Mortality and Health-Related Quality of Life: A Nonprespecified Secondary Analysis of the Life After Pediatric Sepsis Evaluation
Fluid Balance and Its Association With Mortality and Health-Related Quality of Life: A Nonprespecified Secondary Analysis of the Life After Pediatric Sepsis Evaluation Open
OBJECTIVES: To evaluate the association between fluid balance (FB) and health-related quality of life (HRQL) among children at 1 month following community-acquired septic shock. DESIGN: Nonprespecified secondary analysis of the Life After …
View article: Urine Complement Factor Ba Is Associated with AKI in Critically Ill Children
Urine Complement Factor Ba Is Associated with AKI in Critically Ill Children Open
Key Points Complement activation, specifically factor B, is implicated in AKI pathogenesis in animal models. Urine Ba (an activation fragment of factor B) was significantly higher in critically ill children with stage 3 AKI and sepsis-AKI.…
View article: Electrolyte derangements in critically ill children receiving balanced versus unbalanced crystalloid fluid resuscitation
Electrolyte derangements in critically ill children receiving balanced versus unbalanced crystalloid fluid resuscitation Open
Background Adult studies have demonstrated potential harm from resuscitation with 0.9% sodium chloride (0.9%NaCl), resulting in increased utilization of balanced crystalloids like lactated ringers (LR). The sodium and potassium content of …
View article: The complement system in pediatric acute kidney injury
The complement system in pediatric acute kidney injury Open
View article: Use of Relative Blood Volume Monitoring to Reduce Intradialytic Hypotension in Hospitalized Patients Receiving Dialysis
Use of Relative Blood Volume Monitoring to Reduce Intradialytic Hypotension in Hospitalized Patients Receiving Dialysis Open
IntroductionIntradialytic hypotension (IDH) is a frequent complication of hemodialysis in hospitalized patients with acute kidney injury (AKI) who require renal replacement therapy and those with end stage kidney disease (ESKD), occurring …
View article: Management and Associated Toxicokinetics of Massive Valproic Acid Ingestion with High Flow Continuous Venovenous Hemodiafiltration
Management and Associated Toxicokinetics of Massive Valproic Acid Ingestion with High Flow Continuous Venovenous Hemodiafiltration Open
View article: An Apple a Day Keeps Dialysis Away
An Apple a Day Keeps Dialysis Away Open
Kidney transplantation is the preferred treatment for kidney failure and improves both quality of life and mortality. There is a growing discrepancy between eligible recipients on the waiting list and the number of suitable donor kidneys. …
View article: A Pilot Study of the Safety and Efficacy of Alkali Therapy on Vascular Function in Kidney Transplant Recipients
A Pilot Study of the Safety and Efficacy of Alkali Therapy on Vascular Function in Kidney Transplant Recipients Open
View article: Severe SARS-CoV-2 Infection in a Pediatric Patient Requiring Extracorporeal Membrane Oxygenation
Severe SARS-CoV-2 Infection in a Pediatric Patient Requiring Extracorporeal Membrane Oxygenation Open
The overwhelming majority of pediatric cases of SARS-CoV-2 infection are mild or asymptomatic with only a handful of pediatric deaths reported. We present a case of severe COVID-19 infection in a pediatric patient with signs of hyperinflam…
View article: PERSEVERE Biomarkers Predict Severe Acute Kidney Injury and Renal Recovery in Pediatric Septic Shock
PERSEVERE Biomarkers Predict Severe Acute Kidney Injury and Renal Recovery in Pediatric Septic Shock Open
Rationale: Acute kidney injury (AKI), a common complication of sepsis, is associated with substantial morbidity and mortality and lacks definitive disease-modifying therapy. Early, reliable identification of at-risk patients is impo…
View article: <scp>PPAR</scp><i>α</i>contributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis
<span>PPAR</span><i>α</i>contributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis Open
Sepsis-associated acute kidney injury (AKI) is a significant problem in critically ill children and adults resulting in increased morbidity and mortality. Fundamental mechanisms contributing to sepsis-associated AKI are poorly understood. …
View article: The Pediatric Sepsis Biomarker Risk Model (PERSEVERE) Biomarkers Predict Clinical Deterioration and Mortality in Immunocompromised Children Evaluated for Infection
The Pediatric Sepsis Biomarker Risk Model (PERSEVERE) Biomarkers Predict Clinical Deterioration and Mortality in Immunocompromised Children Evaluated for Infection Open
View article: Interleukin-27 as a candidate diagnostic biomarker for bacterial infection in immunocompromised pediatric patients
Interleukin-27 as a candidate diagnostic biomarker for bacterial infection in immunocompromised pediatric patients Open
Despite prior work demonstrating IL-27 and PCT as possible biomarkers of bacterial infection in immunocompromised pediatric patients, we were unable to validate these findings. This illustrates the challenges associated with developing rel…
View article: Hyperchloremia Is Associated With Complicated Course and Mortality in Pediatric Patients With Septic Shock*
Hyperchloremia Is Associated With Complicated Course and Mortality in Pediatric Patients With Septic Shock* Open
Objective: Hyperchloremia is associated with poor outcome among critically ill adults, but it is unknown if a similar association exists among critically ill children. We determined if hyperchloremia is associated with poor outcomes in chi…
View article: Association Between Fluid Balance and Outcomes in Critically Ill Children
Association Between Fluid Balance and Outcomes in Critically Ill Children Open
Fluid overload is common and is associated with substantial morbidity and mortality in critically ill children. Additional research should now ideally focus on interventions aimed to mitigate the potential for harm associated with fluid ov…
View article: Associations Between Fluid Balance and Outcomes in Critically Ill Children
Associations Between Fluid Balance and Outcomes in Critically Ill Children Open
Background: Fluid therapy is a mainstay during the resuscitation of critically ill children. After initial stabilization, excessive fluid accumulation may lead to complications of fluid overload, which has been independently associated wit…