Erin Kaleta
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View article: Descriptive Analysis of Positive Strongyloides Serology Across Three Academic Medical Centers
Descriptive Analysis of Positive Strongyloides Serology Across Three Academic Medical Centers Open
View article: Whole-Blood PCR Preferred for Timely Diagnosis of Neuroinvasive West Nile Virus Infections: Lessons From the 2021 Arizona Outbreak
Whole-Blood PCR Preferred for Timely Diagnosis of Neuroinvasive West Nile Virus Infections: Lessons From the 2021 Arizona Outbreak Open
Background In 2021, the state of Arizona experienced the largest focal outbreak of West Nile virus (WNV) in US history. Timely and accurate diagnostic testing remains a challenge for WNV due to transient viremia and limited immunoassay spe…
View article: Development of a rapid lateral flow assay for detection of anti-coccidioidal antibodies
Development of a rapid lateral flow assay for detection of anti-coccidioidal antibodies Open
Coccidioides spp. are dimorphic fungi that are capable of infecting human and non-human mammals and can cause diverse manifestations of coccidioidomycosis or Valley fever (VF). In combination with clinical symptoms and radiographic finding…
View article: Clinical Laboratory Utility of a Humanized Antibody in Commercially Available Enzyme Immunoassays for Coccidioidomycosis
Clinical Laboratory Utility of a Humanized Antibody in Commercially Available Enzyme Immunoassays for Coccidioidomycosis Open
In southwestern and western regions of the United States, at least half a million diagnostic tests for coccidioidomycosis (valley fever) are run annually. Enzyme immunoassays (EIAs) are blood tests which require precise dilution of patient…
View article: Third COVID-19 vaccine dose boosts neutralizing antibodies in poor responders
Third COVID-19 vaccine dose boosts neutralizing antibodies in poor responders Open
Background While evaluating COVID-19 vaccine responses using a rapid neutralizing antibody (NAb) test, we observed that 25% of mRNA vaccine recipients did not neutralize >50%. We termed this group “vaccine poor responders” (VPRs). The obje…
View article: Third COVID-19 Vaccine Dose Boosts Neutralizing Antibodies in Poor Responders
Third COVID-19 Vaccine Dose Boosts Neutralizing Antibodies in Poor Responders Open
Background While evaluating COVID-19 vaccine responses using a rapid neutralizing antibody (NAb) test, we observed that 25% of RNA vaccine recipients did not neutralize >50%. We termed this group “vaccine poor responders” (VPRs). The objec…
View article: Third COVID-19 Vaccine Dose Boosts Neutralising Antibodies in Poor Responders
Third COVID-19 Vaccine Dose Boosts Neutralising Antibodies in Poor Responders Open
Objective To determine if poor responders to COVID-19 RNA vaccines (<50% neutralisation) after two doses would remain poor responders, or if a third dose could elicit high levels of NAbs. Design Clinical follow-up study Setting Academic an…
View article: Development of a rapid point-of-care test that measures neutralizing antibodies to SARS-CoV-2
Development of a rapid point-of-care test that measures neutralizing antibodies to SARS-CoV-2 Open
View article: NEJM Knowledge+/AACC Learning Lab Contributors 2021
NEJM Knowledge+/AACC Learning Lab Contributors 2021 Open
View article: Development of a Rapid Point-Of-Care Test that Measures Neutralizing Antibodies to SARS-CoV-2
Development of a Rapid Point-Of-Care Test that Measures Neutralizing Antibodies to SARS-CoV-2 Open
Background After receiving a COVID-19 vaccine, most recipients want to know if they are protected from infection and for how long. Since neutralizing antibodies are a correlate of protection, we developed a lateral flow assay (LFA) that me…
View article: Extreme Hyperglycemia in an Elderly Patient
Extreme Hyperglycemia in an Elderly Patient Open
View article: Retrospective clinical evaluation of 4 lateral flow assays for the detection of SARS-CoV-2 IgG
Retrospective clinical evaluation of 4 lateral flow assays for the detection of SARS-CoV-2 IgG Open
View article: Retrospective Clinical Evaluation of Four Lateral Flow Assays for the Detection of SARS-CoV-2 Antibodies
Retrospective Clinical Evaluation of Four Lateral Flow Assays for the Detection of SARS-CoV-2 Antibodies Open
Coronavirus disease 2019 (COVID-19) is a potentially life-threatening respiratory infection caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), for which numerous serologic assays are available. In a CLIA laboratory setting, we …
View article: NEJM Knowledge+/AACC Learning Lab Contributors 2019
NEJM Knowledge+/AACC Learning Lab Contributors 2019 Open
View article: The Critical Necessity of a Well-Written Standard Operating Procedure
The Critical Necessity of a Well-Written Standard Operating Procedure Open
Having a well-structured standard operating procedure (SOP) is a cornerstone for a productive and safe clinical laboratory. It is the foundation of all activities in the lab and ensures that everyone is on the same page when performing tes…
View article: Neonatal Intensive Care Unit Quality Initiative
Neonatal Intensive Care Unit Quality Initiative Open
We identified three variables contributing to hemolysis and instituted two clinical practice interventions to significantly reduce test cancellations due to hemolysis.
View article: Simultaneous Quantitation of 78 Drugs and Metabolites in Urine with a Dilute-And-Shoot LC–MS-MS Assay
Simultaneous Quantitation of 78 Drugs and Metabolites in Urine with a Dilute-And-Shoot LC–MS-MS Assay Open
A novel LC-MS-MS assay that simultaneously detects and quantitates 78 drugs and metabolites was developed and validated for chronic pain management. Urine specimen was diluted and mixed with internal standards (ISs) before injected into LC…
View article: Label-free detection and identification of protein ligands captured by receptors in a polymerized planar lipid bilayer using MALDI-TOF MS
Label-free detection and identification of protein ligands captured by receptors in a polymerized planar lipid bilayer using MALDI-TOF MS Open