Erinn Downs‐Kelly
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Alterations in the preneoplastic breast microenvironment of<i>BRCA1/2</i>mutation carriers revealed by spatial transcriptomics Open
Breast cancer is the most common cancer in females, affecting one in every eight women and accounting for the majority of cancer-related deaths in women worldwide. Germline mutations in the BRCA1 and BRCA2 genes are significant risk factor…
Data from Expression of the MHC Class II Pathway in Triple-Negative Breast Cancer Tumor Cells Is Associated with a Good Prognosis and Infiltrating Lymphocytes Open
Triple-negative breast cancer (TNBC) is a subtype with heterogeneous patient outcomes. Approximately 40% of patients experience rapid relapse, while the remaining patients have long-term disease-free survival. To determine if there are mol…
View article: Supplementary Materials and Methods, Supplementary Figures 1 through 4, and Supplementary Tables 1 and 2 from Expression of the MHC Class II Pathway in Triple-Negative Breast Cancer Tumor Cells Is Associated with a Good Prognosis and Infiltrating Lymphocytes
Supplementary Materials and Methods, Supplementary Figures 1 through 4, and Supplementary Tables 1 and 2 from Expression of the MHC Class II Pathway in Triple-Negative Breast Cancer Tumor Cells Is Associated with a Good Prognosis and Infiltrating Lymphocytes Open
This file contains: Supplementary Methods for Tissue Processing, RNA-seq, RNA-seq analysis, and Immunohistochemistry. Supplementary Figure 1: Overlap between clusters identified in our data and TNBC subtypes described in previous studies. …
View article: Supplementary Materials and Methods, Supplementary Figures 1 through 4, and Supplementary Tables 1 and 2 from Expression of the MHC Class II Pathway in Triple-Negative Breast Cancer Tumor Cells Is Associated with a Good Prognosis and Infiltrating Lymphocytes
Supplementary Materials and Methods, Supplementary Figures 1 through 4, and Supplementary Tables 1 and 2 from Expression of the MHC Class II Pathway in Triple-Negative Breast Cancer Tumor Cells Is Associated with a Good Prognosis and Infiltrating Lymphocytes Open
This file contains: Supplementary Methods for Tissue Processing, RNA-seq, RNA-seq analysis, and Immunohistochemistry. Supplementary Figure 1: Overlap between clusters identified in our data and TNBC subtypes described in previous studies. …
Data from Expression of the MHC Class II Pathway in Triple-Negative Breast Cancer Tumor Cells Is Associated with a Good Prognosis and Infiltrating Lymphocytes Open
Triple-negative breast cancer (TNBC) is a subtype with heterogeneous patient outcomes. Approximately 40% of patients experience rapid relapse, while the remaining patients have long-term disease-free survival. To determine if there are mol…
Two Instrument Comparison of Reagents From a US FDA-Approved Assay for the Assessment of Ki-67 in High-Risk Early Breast Cancer Open
The objective of this study was to measure concordance of results obtained from the US Food and Drug Administration–approved Ki-67 immunohistochemistry MIB-1 pharmDx assay performed on the Dako Omnis automated staining instrument (Omnis) v…
Clinical and Pathologic Features Associated With Invasive Breast Carcinoma With 2018 American Society of Clinical Oncology/College of American Pathologists In Situ Hybridization Group 2 Results (Human Epidermal Growth Factor Receptor 2 [ <i>HER2</i> ]/Chromosome 17 Centromere [CEP17] Ratio ≥2.0 and Average <i>HER2</i> Copy Number <4.0) Open
Context.— The American Society of Clinical Oncology/College of American Pathologists updated the human epidermal growth factor receptor 2 (HER2) breast carcinoma testing guideline in 2018 to address issues from uncommon HER2 fluorescence i…
The 21-Gene Recurrence Score in Special Histologic Subtypes of Breast Cancer Open
Context.— Recurrence score (RS) testing was developed and validated in invasive ductal and rare lobular carcinomas, although it is used for all special types of breast cancers. Objective.— To determine association of histologic type (HT) a…
Novel temporal and spatial patterns of metastatic colonization from rapid-autopsy tumor biopsies Open
Background Metastatic breast cancer is a deadly disease with a low 5-year survival rate. Tracking metastatic spread in living patients is difficult, and thus poorly understood. Results Via rapid autopsy, we have collected 30 tumor samples …
Human breast microbiome correlates with prognostic features and immunological signatures in breast cancer Open
Background Currently, over half of breast cancer cases are unrelated to known risk factors, highlighting the importance of discovering other cancer-promoting factors. Since crosstalk between gut microbes and host immunity contributes to ma…
Additional file 2 of Human breast microbiome correlates with prognostic features and immunological signatures in breast cancer Open
Additional file 2: Table S1. Differentially abundant bacterial taxa according to clinicopathologic features (tissue type, TNM stage, histologic grade, histology).
Additional file 2 of Novel temporal and spatial patterns of metastatic colonization from breast cancer rapid-autopsy tumor biopsies Open
Additional file 2: Tables S1-9.
Additional file 5 of Novel temporal and spatial patterns of metastatic colonization from breast cancer rapid-autopsy tumor biopsies Open
Additional file 5: Somatic SNVs vcf file.
Additional file 6 of Novel temporal and spatial patterns of metastatic colonization from breast cancer rapid-autopsy tumor biopsies Open
Additional file 6: Somatic other variants vcf file.
Additional file 4 of Novel temporal and spatial patterns of metastatic colonization from breast cancer rapid-autopsy tumor biopsies Open
Additional file 4: Somatic SNVs with ssID reference.
Additional file 3 of Human breast microbiome correlates with prognostic features and immunological signatures in breast cancer Open
Additional file 3: Table S2. Differentially expressed genes between tumor (n = 196) versus healthy control (n = 55) breast tissue. Inclusion criteria were |fold change| > 2 and FDR
Pancreatic metastases to the colon: an unusual cause of colonic obstruction Open
We report a case of a 73-year-old woman who developed pancreatic adenocarcinoma and presented with a colonic obstruction due to isolated metastasis to the colon, the primary lesion being diagnosed subsequently on imaging. The histopatholog…
Intramammary Angiomatoid Fibrous Histiocytoma, a Rare<i> EWSR1</i> Rearranged Mesenchymal Neoplasm in a Previously Unreported Anatomic Location with Review of the Cleveland Clinic Experience Open
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor that is most commonly reported to arise in the subcutaneous tissues of the upper extremities in adolescents and young adults. At present, the WHO classifies this neoplasm a…
Primary Cystic Pleuropulmonary Synovial Sarcoma Presenting as Recurrent Pneumothorax Open
Primary pleuropulmonary synovial sarcomas are quite rare, representing 0.1–0.5% of all pulmonary malignancies. We report an entirely cystic monophasic synovial sarcoma in a 25-year-old male who presented with recurrent pneumothorax and no …
Impact of an alternative chromosome 17 probe and the 2013 American Society of Clinical Oncology and College of American Pathologists guidelines on fluorescence in situ hybridization for the determination of <i>HER2</i> gene amplification in breast cancer Open
BACKGROUND The dual‐probe fluorescence in situ hybridization (FISH) assay for human epidermal growth factor receptor 2 ( HER2 ) gene amplification in breast cancer provides an HER2 : CEP17 (centromere enumeration probe for chromosome 17) r…
RAI1 Alternate Probe Identifies Additional Breast Cancer Cases as Amplified Following Equivocal HER2 Fluorescence In Situ Hybridization Testing: Experience From a National Reference Laboratory Open
Context.—In 2013 the American Society of Clinical Oncology and College of American Pathologists updated the HER2 guidelines and changed the equivocal category for HER2 in situ hybridization testing to an average HER2 copy number of 4.0 to …
Inconsistent Results With Different Secondary Reflex Assays for Resolving<i>HER2</i>Status Open
Use of different control loci for ISH is associated with discordant results, and PCR is more likely to classify cases as nonamplified, possibly due to contamination with nontumor cells. While resolution of HER2 -equivocal results is desira…
Automated Bright-Field Dual-Color In Situ Hybridization for MDM2: Interobserver Reproducibility and Correlation With Fluorescence In Situ Hybridization in a Series of Soft Tissue Consults Open
Context.—Atypical lipomatous tumors/well-differentiated liposarcomas contain alterations in the 12q13-15 region resulting in amplification of MDM2 and nearby genes. Identifying MDM2 amplification is a useful ancillary test, as the histolog…
HER2 Immunohistochemistry-Guided Targeted Fluorescence In Situ HybridizationAnalysis Does Not Help Identify Intratumoral Heterogeneity in Breast Cancer Open
The updated 2013 American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) guidelines proposed revised scoring for both immunohistochemical (IHC)– and in situ hybridization–determined HER2 status with the aim of cap…
Targeted Vaccination against Human α-Lactalbumin for Immunotherapy and Primary Immunoprevention of Triple Negative Breast Cancer Open
We have proposed that safe and effective protection against the development of adult onset cancers may be achieved by vaccination against tissue-specific self-proteins that are “retired” from expression at immunogenic levels in normal tiss…
Expression of the MHC Class II Pathway in Triple-Negative Breast Cancer Tumor Cells Is Associated with a Good Prognosis and Infiltrating Lymphocytes Open
Triple-negative breast cancer (TNBC) is a subtype with heterogeneous patient outcomes. Approximately 40% of patients experience rapid relapse, while the remaining patients have long-term disease-free survival. To determine if there are mol…