Erlend A. Nagelhus
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View article: IP3R2-Mediated Astrocytic Ca2+ Transients Are Critical to Sustain Modulatory Effects of Locomotion on Neurons in Mouse Somatosensory Cortex
IP3R2-Mediated Astrocytic Ca2+ Transients Are Critical to Sustain Modulatory Effects of Locomotion on Neurons in Mouse Somatosensory Cortex Open
Accumulating studies have shown that astrocytes are essential for regulating neurons at both synaptic and circuit levels. The main mechanism of brain astrocytic intracellular Ca2+ activity is through the release of Ca2+ via the inositol 1,…
View article: Increased membrane <scp>Ca<sup>2+</sup></scp> permeability drives astrocytic <scp>Ca<sup>2+</sup></scp> dynamics during neuronal stimulation at excitatory synapses
Increased membrane <span>Ca<sup>2+</sup></span> permeability drives astrocytic <span>Ca<sup>2+</sup></span> dynamics during neuronal stimulation at excitatory synapses Open
Astrocytes are intricately involved in the activity of neural circuits; however, their basic physiology of interacting with nearby neurons is not well established. Using two‐photon imaging of neurons and astrocytes during higher frequency …
View article: Deletion of aquaporin‐4 improves capillary blood flow distribution in brain edema
Deletion of aquaporin‐4 improves capillary blood flow distribution in brain edema Open
Brain edema is a feared complication to disorders and insults affecting the brain. It can be fatal if the increase in intracranial pressure is sufficiently large to cause brain herniation. Moreover, accruing evidence suggests that even sli…
View article: Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice
Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice Open
Increased astrocytic Ca 2+ signaling has been shown in Alzheimer’s disease mouse models, but to date no reports have characterized behaviorally induced astrocytic Ca 2+ signaling in such mice. Here, we employ an event-based algorithm to as…
View article: Author response: Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice
Author response: Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Increased…
View article: Impaired astrocytic Ca <sup>2+</sup> signalling in awake Alzheimer’s disease transgenic mice
Impaired astrocytic Ca <sup>2+</sup> signalling in awake Alzheimer’s disease transgenic mice Open
Increased astrocytic Ca 2+ signaling related to amyloid plaques has been shown in Alzheimer’s disease mouse models, but to date no reports have characterized behaviorally induced astrocytic Ca 2+ signalling in such mice without the confoun…
View article: Membrane Ca<sup>2+</sup>permeability and IP3R2 dependent Ca<sup>2+</sup>-induced Ca<sup>2+</sup>release are essential for astrocytic intracellular Ca<sup>2+</sup>elevation upon neuronal stimulation at the mouse hippocampal CA3 - CA1 excitatory synapses
Membrane Ca<sup>2+</sup>permeability and IP3R2 dependent Ca<sup>2+</sup>-induced Ca<sup>2+</sup>release are essential for astrocytic intracellular Ca<sup>2+</sup>elevation upon neuronal stimulation at the mouse hippocampal CA3 - CA1 excitatory synapses Open
Astrocytes are intricately involved in the activity of neural circuits, however, their basic physiology of interacting with neurons remains controversial. Using dual-indicator two-photon imaging of neurons and astrocytes during stimulation…
View article: Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model
Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model Open
The glymphatic system, that is aquaporin 4 (AQP4) facilitated exchange of CSF with interstitial fluid (ISF), may provide a clearance pathway for protein species such as amyloid-β and tau, which accumulate in the brain in Alzheimer’s diseas…
View article: Ca<sup>2+</sup>signaling in astrocytes is sleep-wake state specific and modulates sleep
Ca<sup>2+</sup>signaling in astrocytes is sleep-wake state specific and modulates sleep Open
Summary Astrocytic Ca 2+ signaling has been intensively studied in health and disease but remains uncharacterized in sleep. Here, we employed a novel activity-based algorithm to assess astrocytic Ca 2+ signals in the barrel cortex of awake…
View article: Astroglial endfeet exhibit distinct Ca<sup>2+</sup> signals during hypoosmotic conditions
Astroglial endfeet exhibit distinct Ca<sup>2+</sup> signals during hypoosmotic conditions Open
Astrocytic endfeet cover the brain surface and form a sheath around the cerebral vasculature. An emerging concept is that endfeet control blood–brain water transport and drainage of interstitial fluid and waste along paravascular pathways.…
View article: Blood-Brain Barrier Dysfunction in Idiopathic Intracranial Hypertension
Blood-Brain Barrier Dysfunction in Idiopathic Intracranial Hypertension Open
Idiopathic intracranial hypertension (IIH) is traditionally considered benign and characterized by symptoms related to increased intracranial pressure, including headache and impaired vision. We have previously demonstrated that brains of …
View article: Aquaporin‐4‐independent volume dynamics of astroglial endfeet during cortical spreading depression
Aquaporin‐4‐independent volume dynamics of astroglial endfeet during cortical spreading depression Open
Cortical spreading depression (CSD) is a slowly propagating wave of depolarization of gray matter. This phenomenon is believed to underlie the migraine aura and similar waves of depolarization may exacerbate injury in a number of neurologi…
View article: Ca2+ Signals in Astrocytes Facilitate Spread of Epileptiform Activity
Ca2+ Signals in Astrocytes Facilitate Spread of Epileptiform Activity Open
Epileptic seizures are associated with increased astrocytic Ca2+ signaling, but the fine spatiotemporal kinetics of the ictal astrocyte-neuron interplay remains elusive. By using 2-photon imaging of awake head-fixed mice with chronic hippo…
View article: IC‐06‐02: NON‐INVASIVE IMAGING OF BRAIN CLEARANCE PATHWAYS USING MULTIPLE ECHO TIME ARTERIAL SPIN LABELLING: AN AQUAPORIN‐4 STUDY
IC‐06‐02: NON‐INVASIVE IMAGING OF BRAIN CLEARANCE PATHWAYS USING MULTIPLE ECHO TIME ARTERIAL SPIN LABELLING: AN AQUAPORIN‐4 STUDY Open
Evidence suggests that impaired rates of clearance increase amyloid-β (Aβ) accumulation in Alzheimer's disease (AD). Brain aquaporin-4 (AQP4) water channels appear to play a key role in Aβ clearance, possibly via the glymphatic pathway. To…
View article: LTP induction boosts glutamate spillover by driving withdrawal of astroglia
LTP induction boosts glutamate spillover by driving withdrawal of astroglia Open
SUMMARY Extrasynaptic actions of glutamate are limited by high-affinity transporters on perisynaptic astroglial processes (PAPs), which helps to maintain point-to-point transmission in excitatory circuits. Memory formation in the brain is …
View article: Brain Capillary Ultrastructure in Idiopathic Normal Pressure Hydrocephalus: Relationship With Static and Pulsatile Intracranial Pressure
Brain Capillary Ultrastructure in Idiopathic Normal Pressure Hydrocephalus: Relationship With Static and Pulsatile Intracranial Pressure Open
Idiopathic normal pressure hydrocephalus (iNPH) is a neurodegenerative disease of unknown cause. We investigated the morphology of capillaries in frontal cortex biopsies from iNPH patients and related the observations to overnight intracra…
View article: Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow
Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow Open
Significance Transport of nutrients and clearance of waste products are prerequisites for healthy brain function. It is still debated whether solutes are transported through the interstitial space by pressure-mediated bulk flow or by diffu…
View article: Human and mouse cortical astrocytes differ in aquaporin-4 polarization toward microvessels
Human and mouse cortical astrocytes differ in aquaporin-4 polarization toward microvessels Open
Aquaporin-4 (AQP4), the predominant water channel in the brain, is expressed in astrocytes and ependymal cells. In rodents AQP4 is highly polarized to perivascular astrocytic endfeet and loss of AQP4 polarization is associated with disease…
View article: Deletion of Aquaporin-4 Curtails Extracellular Glutamate Elevation in Cortical Spreading Depression in Awake Mice
Deletion of Aquaporin-4 Curtails Extracellular Glutamate Elevation in Cortical Spreading Depression in Awake Mice Open
Cortical spreading depression (CSD) is a phenomenon that challenges the homeostatic mechanisms on which normal brain function so critically depends. Analyzing the sequence of events in CSD holds the potential of providing new insight in th…