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View article: Lactate Dehydrogenase in Patients with Metastatic Colorectal Cancer: Retrospective Study to Explore a Target Subgroup for Utilization as a Tumor Marker
Lactate Dehydrogenase in Patients with Metastatic Colorectal Cancer: Retrospective Study to Explore a Target Subgroup for Utilization as a Tumor Marker Open
Aim: Serum lactate dehydrogenase (LDH) may be a prognostic marker in metastatic colorectal cancer (mCRC). However, mCRC is a heterogeneous disease, and data on LDH-related subgroups are limited. This study aimed to investigate clinical and…
View article: Chemotherapy tolerance and continuity are prognostic for overall survival in patients with localized and advanced biliary tract cancer
Chemotherapy tolerance and continuity are prognostic for overall survival in patients with localized and advanced biliary tract cancer Open
This study shows that a significant proportion of patients with BTC are not eligible or intolerant to chemotherapy in the real world. Maintaining the planned treatment, even with dose reduction, is associated with better OS.
View article: Individualized Triplet Chemotherapy Decision-Making in Metastatic Colorectal Cancer: A Machine-Learning-Driven Study
Individualized Triplet Chemotherapy Decision-Making in Metastatic Colorectal Cancer: A Machine-Learning-Driven Study Open
Objective: The optimal patient subgroup that derives substantial benefit from triplet chemotherapy (FOLFOXIRI/FOLFIRINOX) as first-line treatment for metastatic colorectal cancer (mCRC), and the clinical scenarios in which its increased to…
View article: Assessing the Influence of Proton Pump Inhibitors on Clinical Outcomes in Hormone Receptor-Positive Metastatic Breast Cancer Patients Receiving CDK4/6 Inhibitors: Evidence from a Ribociclib-Dominant Cohort
Assessing the Influence of Proton Pump Inhibitors on Clinical Outcomes in Hormone Receptor-Positive Metastatic Breast Cancer Patients Receiving CDK4/6 Inhibitors: Evidence from a Ribociclib-Dominant Cohort Open
Background and Objectives: Endocrine therapy combined with CDK4/6 inhibitors are widely recognized as the standard first-line approach for treating hormone receptor-positive HER2-negative (HR+/HER2−) metastatic breast cancer (mBC). Nonethe…
View article: Assessment of Fear of Cancer Recurrence in Patients with Colorectal Cancer and Its Association with Pet Ownership: A Cross-Sectional Study
Assessment of Fear of Cancer Recurrence in Patients with Colorectal Cancer and Its Association with Pet Ownership: A Cross-Sectional Study Open
Fear of cancer recurrence (FCR) is a frequent and distressing concern among colorectal cancer (CRC) survivors, often exerting a profound impact on psychological well-being, daily functioning, and treatment adherence. While several clinical…
View article: Metabolic dysfunction‐associated steatotic liver disease, insulin resistance and hepatocellular carcinoma: A deadly triad
Metabolic dysfunction‐associated steatotic liver disease, insulin resistance and hepatocellular carcinoma: A deadly triad Open
Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) has become a leading cause of chronic liver disease worldwide, driven by the increasing prevalence of obesity and insulin resistance (IR). IR, a central feature of…
View article: Stage‐specific characterization of “early‐onset colorectal cancer”: Localized and synchronous metastatic disease
Stage‐specific characterization of “early‐onset colorectal cancer”: Localized and synchronous metastatic disease Open
Early‐onset colorectal cancer (EOCRC) is an alarming entity worldwide. Yet, stage‐specific characteristics and prognosis in localized and synchronous metastatic EOCRC are not well‐defined. Two cohorts of CRC patients (localized and synchro…
View article: Targeting the bioenergetics of a resistant tumor: clinical insights into OXPHOS inhibition for cancer therapy
Targeting the bioenergetics of a resistant tumor: clinical insights into OXPHOS inhibition for cancer therapy Open
Graphical abstract Abstract Although a century has passed since Otto Warburg’s discovery of the glycolytic pathway of energy production by many malignant tumors compared to normal tissues, current data cast doubt on the universality of thi…
View article: Types and Rates of COVID-19 Vaccination in Patients With Newly Diagnosed Microsatellite Stable and Instable Non-Metastatic Colon Cancer
Types and Rates of COVID-19 Vaccination in Patients With Newly Diagnosed Microsatellite Stable and Instable Non-Metastatic Colon Cancer Open
Introduction Microsatellite instable (deficient mismatch repair, dMMR) colon cancer is associated with hypermutability and immune infiltration-activation. COVID-19 vaccines stimulate immune-inflammation response. This study aimed to invest…
View article: Germline genetic variants in Turkish familial multiple myeloma/monoclonal gammopathy of undetermined significance cases
Germline genetic variants in Turkish familial multiple myeloma/monoclonal gammopathy of undetermined significance cases Open
Summary Multiple myeloma (MM) is a haematological malignancy primarily affecting the elderly, with a striking male predilection and ethnic disparities in incidence. Familial predisposition to MM has long been recognized, but the genetic un…
View article: Crizotinib efficacy and safety in patients with advanced NSCLC harboring MET alterations: A real-life data of Turkish Oncology Group
Crizotinib efficacy and safety in patients with advanced NSCLC harboring MET alterations: A real-life data of Turkish Oncology Group Open
Crizotinib is a multikinase inhibitor, effective in non-small cell lung cancer (NSCLC) harboring mesenchymal-epidermal transition (MET) alterations. Although small prospective studies showed efficacy and safety of crizotinib in NSCLC with …
View article: The relationship between clinicopathological parameters and PD-L1 expression level in advanced stage non-small cell lung cancer
The relationship between clinicopathological parameters and PD-L1 expression level in advanced stage non-small cell lung cancer Open
According to the results of our study, many of the clinicopathological parameters are not related to the PD-L1 level. The histological subtype and diagnostic material may affect the level of PD-L1 expression.
View article: Brentuksimab Vedotin Treatment in Relaps Refractory Hodgkin Lymphoma: A Single Center Experience
Brentuksimab Vedotin Treatment in Relaps Refractory Hodgkin Lymphoma: A Single Center Experience Open
Amaç: Bu retrospektif çalışmada relaps/refrakter (R/R) hodgkin lenfoma (HL) hasta grubunda brentuksimab vedotin (BV) tedavisinin etkinlik ve güvenilirliğini göstermeyi amaçlayan
View article: Association Between Blood Type and Epidermal Growth Factor Receptor Mutation Positivity in Lung Adenocarcinoma Patients
Association Between Blood Type and Epidermal Growth Factor Receptor Mutation Positivity in Lung Adenocarcinoma Patients Open
Lung cancer is the most common cancer worldwide in both females and males. 1 The non-small cell lung cancer (NSCLC) distribution among all lung cancer is approximately 85%, and adenocarcinoma is the most common histological subtype in both…
View article: Comment on “Potential role of ACE2 in coronavirus disease 2019 (COVID-19) prevention and management”
Comment on “Potential role of ACE2 in coronavirus disease 2019 (COVID-19) prevention and management” Open
Sciendo provides publishing services and solutions to academic and professional organizations and individual authors. We publish journals, books, conference proceedings and a variety of other publications.
View article: Mean platelet volume and response to the first line therapy in newly diagnosed adult immune thrombocytopenia patients: a retrospective study
Mean platelet volume and response to the first line therapy in newly diagnosed adult immune thrombocytopenia patients: a retrospective study Open
MPV can be used as a predictor of early response to the first line treatment in newly diagnosed adult primary ITP patients.
View article: A Case of Acute Myeloid Leukemia Transformed from Myelodisplastic Syndrome Which Relapsed with der(1) t(1;19) Chromosomal Abnormality After Allogenic Transplantation
A Case of Acute Myeloid Leukemia Transformed from Myelodisplastic Syndrome Which Relapsed with der(1) t(1;19) Chromosomal Abnormality After Allogenic Transplantation Open
Transplantation ÖZETSitogenetik değişiklikler, miyeloid ve lenfoid malignitelerin patofizyolojisi, risk sınıflaması, tedavi ve prognozunu belirlemede büyük önem taşımaktadır.Sıklıkla çocukluk çağı akut lenfoblastik lösemilerinde görülen t(…
View article: KIR Genotype and KIR Ligand Phenotypes That Improve the in Vitro Cord Blood or Autologous NK Cell Mediated Cytotoxicity Against Myeloma Marrow Plasma Cells
KIR Genotype and KIR Ligand Phenotypes That Improve the in Vitro Cord Blood or Autologous NK Cell Mediated Cytotoxicity Against Myeloma Marrow Plasma Cells Open
InstructionKiller Immunoglobulin-like Receptor (KIR) inhibition is known to influence the cytotoxic effects of natural killer (NK) cells against cancer cells. KIRs can be protective against relapse in myeloma (MM) (Gabriel et al Blood 2010…
View article: Radiotherapy-Related Dural Sarcoma and Its Management: Case Report
Radiotherapy-Related Dural Sarcoma and Its Management: Case Report Open
ABS TRACT Sarcomas are malignant neoplasms that arise from mesenchymal tissues.Sarcomas of the meninges may originate primarily from mesenchymal cells or may be metastases of extracranial soft tissue sarcomas.Radiotherapy (RT)-related dura…