Ernest O. Asare
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View article: Drought, Extreme Heat, and Intimate Partner Violence in Low- and Middle-Income Countries
Drought, Extreme Heat, and Intimate Partner Violence in Low- and Middle-Income Countries Open
Importance Recent evidence has shown that elevated temperatures are associated with a higher risk of intimate partner violence (IPV), a serious violation of human rights. However, it remains unclear whether drought also heightens the risk …
View article: How well do disease-specific studies and WHO-CHOICE cost estimates align? Example of estimating cost per episode of diarrhoea and respiratory syncytial virus in 128 low-income and middle-income countries
How well do disease-specific studies and WHO-CHOICE cost estimates align? Example of estimating cost per episode of diarrhoea and respiratory syncytial virus in 128 low-income and middle-income countries Open
Objective Non-disease-specific WHO-CHOICE (CHOosing Interventions that are Cost-Effective) unit costs are often used in cost and cost-effectiveness studies in the absence of country-specific data. This study aims to compare reported countr…
View article: Evaluating the kidney disease progression using a comprehensive patient profiling algorithm: A hybrid clustering approach
Evaluating the kidney disease progression using a comprehensive patient profiling algorithm: A hybrid clustering approach Open
Background Acute kidney injury (AKI) can lead to an approximate ninefold increased risk for developing chronic kidney disease (CKD). Despite this, many AKI survivors lack proper nephrology follow-up, highlighting the urgent need to identif…
View article: Cost-effectiveness analysis of alternative infant and neonatal rotavirus vaccination schedules in Malawi
Cost-effectiveness analysis of alternative infant and neonatal rotavirus vaccination schedules in Malawi Open
Rotavirus is the leading cause of severe diarrhea among children under five worldwide, especially in low- and middle-income countries (LMICs). Although vaccination is the best strategy to prevent rotavirus, obstacles leading to poor vaccin…
View article: Global estimates of rotavirus vaccine efficacy and effectiveness: a rapid review and meta-regression analysis
Global estimates of rotavirus vaccine efficacy and effectiveness: a rapid review and meta-regression analysis Open
National Institutes of Health/National Institute of Allergy and Infectious Diseases (R01AI112970) and the Bill & Melinda Gates Foundation (INV-17940).
View article: Long-term drought and risk of infant mortality in Africa: A cross-sectional study
Long-term drought and risk of infant mortality in Africa: A cross-sectional study Open
Background As extreme events such as drought and flood are projected to increase in frequency and intensity under climate change, there is still large missing evidence on how drought exposure potentially impacts mortality among young child…
View article: Impact of dosing schedules on performance of rotavirus vaccines in Ghana
Impact of dosing schedules on performance of rotavirus vaccines in Ghana Open
There is currently limited evidence regarding how the rotavirus vaccine dosing schedule might be adjusted to improve vaccine performance. We quantified the impact of the previously implemented 6/10-week Rotarix vaccine (RV1) in Ghana to th…
View article: Cost-effectiveness Analysis of Alternative Infant and Neonatal Rotavirus Vaccination Schedules in Malawi
Cost-effectiveness Analysis of Alternative Infant and Neonatal Rotavirus Vaccination Schedules in Malawi Open
Rotavirus is the leading cause of severe diarrhea among children under five worldwide, especially in low- and middle-income countries (LMICs). Although vaccination is the best strategy for preventing rotavirus infection, obstacles leading …
View article: Impact of rotavirus vaccination in Malawi from 2012 to 2022 compared to model predictions
Impact of rotavirus vaccination in Malawi from 2012 to 2022 compared to model predictions Open
View article: Evaluating the kidney disease progression using a comprehensive patient profiling algorithm: A hybrid clustering approach
Evaluating the kidney disease progression using a comprehensive patient profiling algorithm: A hybrid clustering approach Open
Background Among 35.5 million U.S. adults with chronic kidney disease (CKD), more than 557,000 are on dialysis with incurred cost ranges from $97,373 to $102,206 per patient per year. Acute kidney injury (AKI) can lead to an approximate ni…
View article: Cost per episode of diarrhea and respiratory syncytial virus (RSV) in 128 low- and middle-income countries: how well do disease-specific and WHO-CHOICE estimates align?
Cost per episode of diarrhea and respiratory syncytial virus (RSV) in 128 low- and middle-income countries: how well do disease-specific and WHO-CHOICE estimates align? Open
Objective Non-disease-specific WHO-CHOICE unit costs are often used in cost and cost-effectiveness studies in the absence of country-specific data. This study aims to compare reported country-specific disease costs and the corresponding WH…
View article: Impact of dosing schedules on performance of rotavirus vaccines in Ghana
Impact of dosing schedules on performance of rotavirus vaccines in Ghana Open
Background Available live-oral rotavirus vaccines are associated with low to moderate performance in low- and middle-income settings. There is limited evidence relating to how the vaccine dosing schedule might be adjusted to improve vaccin…
View article: Impact of rotavirus vaccination in Malawi from 2012 to 2022 compared to model predictions before, during, and after the COVID-19 pandemic
Impact of rotavirus vaccination in Malawi from 2012 to 2022 compared to model predictions before, during, and after the COVID-19 pandemic Open
Background Rotarix® rotavirus vaccine was introduced into the Malawi national immunization program in October 2012. We used a previously developed mathematical models to estimate overall vaccine effectiveness over a 10-year period followin…
View article: Global Estimates of Rotavirus Vaccine Efficacy and Effectiveness: A Meta-Regression Analysis
Global Estimates of Rotavirus Vaccine Efficacy and Effectiveness: A Meta-Regression Analysis Open
View article: Floods and Diarrhea Risk in Young Children in Low- and Middle-Income Countries
Floods and Diarrhea Risk in Young Children in Low- and Middle-Income Countries Open
Importance Climate change is associated with more frequent and intense floods. Current research on the association between flood exposure and diarrhea risk is limited mainly to short-term and event-specific analyses. Moreover, how prior dr…
View article: Climate Drivers of Malaria Transmission Seasonality and Their Relative Importance in Sub‐Saharan Africa
Climate Drivers of Malaria Transmission Seasonality and Their Relative Importance in Sub‐Saharan Africa Open
A new database of the Entomological Inoculation Rate (EIR) was used to directly link the risk of infectious mosquito bites to climate in Sub‐Saharan Africa. Applying a statistical mixed model framework to high‐quality monthly EIR measureme…
View article: Long-term Drought and Diarrhea among Children under Five and the Role of Water, Sanitation, and Hygiene Practices
Long-term Drought and Diarrhea among Children under Five and the Role of Water, Sanitation, and Hygiene Practices Open
Background and Aim. Climate change is projected to intensify drought conditions, which may increase the risk of diarrheal diseases in children. However, evidence on the association between drought and diarrhea risk is scarce. This study ai…
View article: Climate drivers of malaria seasonality and their relative importance in Sub-Saharan Africa
Climate drivers of malaria seasonality and their relative importance in Sub-Saharan Africa Open
A new database of the Entomological Inoculation Rate (EIR) is used to directly link the risk of infectious mosquito bites to climate in Sub-Saharan Africa. Applying a statistical mixed model framework to high-quality monthly EIR measuremen…
View article: Associations between long-term drought and diarrhea among children under five in low- and middle-income countries
Associations between long-term drought and diarrhea among children under five in low- and middle-income countries Open
View article: The influence of demographic and meteorological factors on temporal patterns of rotavirus infection in Dhaka, Bangladesh
The influence of demographic and meteorological factors on temporal patterns of rotavirus infection in Dhaka, Bangladesh Open
To quantify the potential impact of rotavirus vaccines and identify strategies to improve vaccine performance in Bangladesh, a better understanding of the drivers of pre-vaccination rotavirus patterns is required. We developed and fitted m…
View article: Case fatality risk of diarrhoeal pathogens: a systematic review and meta-analysis
Case fatality risk of diarrhoeal pathogens: a systematic review and meta-analysis Open
Background Estimates of the relative contribution of different pathogens to all-cause diarrhoea mortality are needed to inform global diarrhoea burden models and prioritize interventions. We aimed to investigate and estimate heterogeneity …
View article: Spatiotemporal Patterns of Diarrhea Incidence in Ghana and the Impact of Meteorological and Socio-Demographic Factors
Spatiotemporal Patterns of Diarrhea Incidence in Ghana and the Impact of Meteorological and Socio-Demographic Factors Open
Background Diarrhea remains a significant public health problem and poses a considerable financial burden on Ghana's health insurance scheme. In order to prioritize district-level hotspots of diarrhea incidence for effective targeted inter…
View article: Associations Between Drought and Childhood Diarrhea in Low- and Middle-Income Countries
Associations Between Drought and Childhood Diarrhea in Low- and Middle-Income Countries Open
BACKGROUND AND AIM: Diarrheal diseases are the fifth leading cause of death among children under five. Climate change is projected to intensify hydrological variability and extreme weather events such as drought. However, current evidence …
View article: Modeling of rotavirus transmission dynamics and impact of vaccination in Ghana
Modeling of rotavirus transmission dynamics and impact of vaccination in Ghana Open
View article: Modeling of rotavirus transmission dynamics and impact of vaccination in Ghana
Modeling of rotavirus transmission dynamics and impact of vaccination in Ghana Open
Background Rotavirus incidence remains relatively high in low-income countries (LICs) compared to high-income countries (HICs) after vaccine introduction. Ghana introduced monovalent rotavirus vaccine in April 2012 and despite the high cov…
View article: Modelled and observed mean and seasonal relationships between climate, population density and malaria indicators in Cameroon
Modelled and observed mean and seasonal relationships between climate, population density and malaria indicators in Cameroon Open
View article: Machine learning methods to forecast temporal pattern of Aedes mosquito species using meteorological variables in Ontario, Canada
Machine learning methods to forecast temporal pattern of Aedes mosquito species using meteorological variables in Ontario, Canada Open
View article: Assessing Climate Driven Malaria Variability in Ghana Using a Regional Scale Dynamical Model
Assessing Climate Driven Malaria Variability in Ghana Using a Regional Scale Dynamical Model Open
Malaria is a major public health challenge in Ghana and adversely affects the productivity and economy of the country. Although malaria is climate driven, there are limited studies linking climate variability and disease transmission acros…
View article: A breeding site model for regional, dynamical malaria simulations evaluated using in situ temporary ponds observations
A breeding site model for regional, dynamical malaria simulations evaluated using in situ temporary ponds observations Open
Daily observations of potential mosquito developmental habitats in a suburb of Kumasi in central Ghana reveal a strong variability in their water persistence times, which ranged between 11 and 81 days. The persistence of the ponds was stro…
View article: Mosquito breeding site water temperature observations and simulations towards improved vector-borne disease models for Africa
Mosquito breeding site water temperature observations and simulations towards improved vector-borne disease models for Africa Open
An energy budget model is developed to predict water temperature of typical mosquito larval developmental habitats. It assumes a homogeneous mixed water column driven by empirically derived fluxes. The model shows good agreement at both ho…