Ernesto Zecca
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View article: Denosumab versus zoledronic acid: analgesic and survival impact of an extended treatment regimen beyond 2 years in breast cancer
Denosumab versus zoledronic acid: analgesic and survival impact of an extended treatment regimen beyond 2 years in breast cancer Open
View article: Denosumab versus zoledronic acid in metastatic breast cancer: A retrospective observational analysis of 24-dose regimens on analgesia and skeletal-related event prevention
Denosumab versus zoledronic acid in metastatic breast cancer: A retrospective observational analysis of 24-dose regimens on analgesia and skeletal-related event prevention Open
View article: Patient Voices: Multimethod Study on the Feasibility of Implementing Electronic Patient-Reported Outcome Measures in a Comprehensive Cancer Center
Patient Voices: Multimethod Study on the Feasibility of Implementing Electronic Patient-Reported Outcome Measures in a Comprehensive Cancer Center Open
Background “Patient Voices” is a software developed to promote the systematic collection of electronic patient-reported outcome measures (ePROMs) in routine oncology clinical practice. Objective This study aimed to assess compliance with a…
View article: Denosumab Versus Zoledronic Acid in Metastatic Breast Cancer: A Retrospective Observational Analysis of 24-Dose Regimens on Analgesia and Skeletal-Related Event Prevention
Denosumab Versus Zoledronic Acid in Metastatic Breast Cancer: A Retrospective Observational Analysis of 24-Dose Regimens on Analgesia and Skeletal-Related Event Prevention Open
View article: Denosumab Versus Zoledronic Acid: Analgesic and Survival Impact of an Extended Treatment Regimen Beyond 2 Years in Breast Cancer
Denosumab Versus Zoledronic Acid: Analgesic and Survival Impact of an Extended Treatment Regimen Beyond 2 Years in Breast Cancer Open
View article: A genome‐wide association study of European advanced cancer patients treated with opioids identifies regulatory variants on chromosome 20 associated with pain intensity
A genome‐wide association study of European advanced cancer patients treated with opioids identifies regulatory variants on chromosome 20 associated with pain intensity Open
Background Opioids in step III of the WHO analgesic ladder are the standard of care for treating cancer pain. However, a significant minority of patients do not benefit from therapy. Genetics might play a role in predisposing patients to a…
View article: Genomic Study in Opioid-Treated Cancer Patients Identifies Variants Associated With Nausea-Vomiting
Genomic Study in Opioid-Treated Cancer Patients Identifies Variants Associated With Nausea-Vomiting Open
View article: A European pharmacogenomic study of the response to opioids in advanced cancer patients identifies germline variants associated with nausea-vomiting side effect
A European pharmacogenomic study of the response to opioids in advanced cancer patients identifies germline variants associated with nausea-vomiting side effect Open
Opioids are the mainstay therapy for patients affected by moderate to severe cancer pain, yet in about 10–20% of the cases, patients do not benefit from the received analgesic treatment or experience side effects. Genetic variability might…
View article: Anticancer Drugs-Related Hypogonadism in Male Patients with Advanced Cancers on Active Treatment: A Systematic Review
Anticancer Drugs-Related Hypogonadism in Male Patients with Advanced Cancers on Active Treatment: A Systematic Review Open
Background In male patients with cancer treated with antineoplastic drug, hypogonadism is a neglected cause of diminished quality of life. This condition may be cancer related as well as toxicity related. The role of antineoplastic drug in…
View article: Application and accuracy of the EAPC/IASP diagnostic algorithm for neuropathic cancer pain and quantitative sensory testing profile in patients with pain due to cancer
Application and accuracy of the EAPC/IASP diagnostic algorithm for neuropathic cancer pain and quantitative sensory testing profile in patients with pain due to cancer Open
Introduction: Better diagnosis and treatment of neuropathic cancer pain (NcP) remains an unmet clinical need. The EAPC/IASP algorithm was specifically designed for NcP diagnosis; yet, to date, there is no information on its application and…
View article: Finding predictors for successful opioid response in cancer patients: An analysis of data from four randomized controlled trials
Finding predictors for successful opioid response in cancer patients: An analysis of data from four randomized controlled trials Open
Context There is no consensus on which “strong” (or step 3 WHO analgesic ladder) opioid to prescribe to a particular patient with cancer‐related pain. A better understanding of opioid and patient characteristics on treatment response will …
View article: A real‐world study on the prevalence and risk factors of medication related osteonecrosis of the jaw in cancer patients with bone metastases treated with Denosumab
A real‐world study on the prevalence and risk factors of medication related osteonecrosis of the jaw in cancer patients with bone metastases treated with Denosumab Open
Aim Assessing the incidence of Medication Related Osteonecrosis of the Jaw (MRONJ) in cancer patients with bone metastases receiving Denosumab (Dmab) and identifying potential risk factors. Methods A retrospective observational study on co…
View article: Characterizing Different Multidisciplinary Team Models Implemented Within One Comprehensive Cancer Center
Characterizing Different Multidisciplinary Team Models Implemented Within One Comprehensive Cancer Center Open
Despite a high number of MDTWs for advanced/metastatic disease, there is limited involvement of palliative care specialists, psychologists, and nurses.
View article: Development of the palliative care referral system: proposal of a tool for the referral of cancer patients to specialized palliative care
Development of the palliative care referral system: proposal of a tool for the referral of cancer patients to specialized palliative care Open
Background Early palliative care (PC) has shown beneficial effects for advanced cancer patients. However, it is still debated what criteria to use to identify patients for PC referral. Aim To document the initial steps of the development o…
View article: Outpatient palliative care referral system (PCRS) for patients with advanced cancer: an impact evaluation protocol
Outpatient palliative care referral system (PCRS) for patients with advanced cancer: an impact evaluation protocol Open
Introduction Early palliative care (PC) in the clinical pathway of advanced cancer patients improves symptom control, quality of life and has a positive impact on overall quality of care. At present, standardised criteria for appropriate r…
View article: Cancer pain: Results of a prospective study on prognostic indicators of pain intensity including pain syndromes assessment
Cancer pain: Results of a prospective study on prognostic indicators of pain intensity including pain syndromes assessment Open
Background: Pain is a prevalent symptom in patients with advanced cancer. Recognition of prognostic factors associated with pain intensity, could help provide better assessment, leading to better pain management. Aim: identifying prognosti…
View article: Telemedicine for outpatient palliative care during COVID-19 pandemics: a longitudinal study
Telemedicine for outpatient palliative care during COVID-19 pandemics: a longitudinal study Open
Objectives During the COVID-19 pandemic, telemedicine (TM) emerged as an important mean to reduce risks of transmission, yet delivering the necessary care to patients. Our aim was to evaluate feasibility, characteristics and satisfaction f…
View article: Neuropathic pain: clinical classification and assessment in patients with pain due to cancer
Neuropathic pain: clinical classification and assessment in patients with pain due to cancer Open
Neuropathic cancer pain (NcP) is associated with worse treatment responses and specific therapy indications, but a standardized clinical diagnosis of NcP is still lacking. This is a prospective observational study on outpatients with cance…
View article: Effect of Opioid Exposure on Efficacy and Tolerability of Sublingual Fentanyl and Subcutaneous Morphine for Severe Cancer Pain Episodes. Secondary Analysis From a Double-Blind Double-Dummy, Randomized Trial
Effect of Opioid Exposure on Efficacy and Tolerability of Sublingual Fentanyl and Subcutaneous Morphine for Severe Cancer Pain Episodes. Secondary Analysis From a Double-Blind Double-Dummy, Randomized Trial Open
View article: Integration of Palliative and Oncology Care in patients with lung and other thoracic cancer: referral criteria and clinical care pathways
Integration of Palliative and Oncology Care in patients with lung and other thoracic cancer: referral criteria and clinical care pathways Open
View article: Comparison of the Tolerability Profile of Controlled-Release Oral Morphine and Oxycodone for Cancer Pain Treatment. An Open-Label Randomized Controlled Trial
Comparison of the Tolerability Profile of Controlled-Release Oral Morphine and Oxycodone for Cancer Pain Treatment. An Open-Label Randomized Controlled Trial Open
View article: Are strong opioids equally effective and safe in the treatment of chronic cancer pain? A multicenter randomized phase IV ‘real life’ trial on the variability of response to opioids
Are strong opioids equally effective and safe in the treatment of chronic cancer pain? A multicenter randomized phase IV ‘real life’ trial on the variability of response to opioids Open
View article: Pharmacokinetic study between a bilayer matrix fentalyl patch and a monolayer matrix fentanyl patch: single dose administration in healthy volunteers
Pharmacokinetic study between a bilayer matrix fentalyl patch and a monolayer matrix fentanyl patch: single dose administration in healthy volunteers Open
Aims Transdermal fentanyl is a well established treatment for cancer pain. The aim of the present study is to assess the relative bioavailability of fentanyl from two different transdermal systems by evaluating plasma drug concentrations a…