Ernst Blum
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View article: Modulating ADME Properties by Fluorination: MK2 Inhibitors with Improved Oral Exposure
Modulating ADME Properties by Fluorination: MK2 Inhibitors with Improved Oral Exposure Open
MAP-activated protein kinase 2 (MK2) plays an important role in the regulation of innate immune response as well as in cell survival upon DNA damage. Despite its potential for the treatment of inflammation and cancer, to date no MK2 low mo…