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View article: Morphogen-driven differentiation is precluded by physical confinement in human iPSCs spheroids
Morphogen-driven differentiation is precluded by physical confinement in human iPSCs spheroids Open
Introduction Cell lineage specification is tightly associated with profound morphological changes in the developing human embryo, particularly during gastrulation. The interplay between mechanical forces and biochemical signals is poorly u…
View article: Morphogen-driven human iPSCs differentiation in 3D <i>in vitro</i> models of gastrulation is precluded by physical confinement
Morphogen-driven human iPSCs differentiation in 3D <i>in vitro</i> models of gastrulation is precluded by physical confinement Open
In early human development, gastrulation is tightly associated with lineage specification. The interplay between mechanical forces and biochemical signals during these processes is poorly understood. Here, we dissect the effects of biochem…
View article: 3D multicellular systems in disease modelling: From organoids to organ-on-chip
3D multicellular systems in disease modelling: From organoids to organ-on-chip Open
Cell-cell interactions underlay organ formation and function during homeostasis. Changes in communication between cells and their surrounding microenvironment are a feature of numerous human diseases, including metabolic disease and neurol…
View article: High-content image analysis to study phenotypic heterogeneity in endothelial cell monolayers
High-content image analysis to study phenotypic heterogeneity in endothelial cell monolayers Open
Endothelial cells (ECs) are heterogeneous across and within tissues, reflecting distinct, specialised functions. EC heterogeneity has been proposed to underpin EC plasticity independently from vessel microenvironments. However, heterogenei…
View article: High content Image Analysis to study phenotypic heterogeneity in endothelial cell monolayers
High content Image Analysis to study phenotypic heterogeneity in endothelial cell monolayers Open
Endothelial cells (EC) are heterogeneous across and within tissues, reflecting distinct, specialised functions. EC heterogeneity has been proposed to underpin EC plasticity independently from vessel microenvironments. However, heterogeneit…