Eshan Ghosh
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View article: An Online Biased Signaling Atlas
An Online Biased Signaling Atlas Open
Biased signaling is a paradigm in signal transduction whereby hormones, probes, or drugs bind the same receptor but engage different intracellular signaling pathways leading to distinct functional outcomes. Whereas there is a wealth of kno…
View article: Conformational sensors and domain-swapping reveal structural and functional differences between β-arrestin isoforms
Conformational sensors and domain-swapping reveal structural and functional differences between β-arrestin isoforms Open
Summary Desensitization, signaling and trafficking of G protein-coupled receptors (GPCRs) are critically regulated by multifunctional adaptor proteins, β-arrestins (βarrs). The two isoforms of βarrs (βarr1 and 2) share a high degree of seq…
View article: Genetically encoded intrabody sensors illuminate structural and functional diversity in GPCR-β-arrestin complexes
Genetically encoded intrabody sensors illuminate structural and functional diversity in GPCR-β-arrestin complexes Open
Interaction of β-arrestins (βarrs) upon agonist-stimulation is a hallmark of G protein-coupled receptors (GPCRs) resulting in receptor desensitization, endocytosis and signaling. Although overall functional roles of βarrs are typically bel…
View article: Core engagement with β-arrestin is dispensable for agonist-induced vasopressin receptor endocytosis and ERK activation
Core engagement with β-arrestin is dispensable for agonist-induced vasopressin receptor endocytosis and ERK activation Open
G protein–coupled receptors (GPCRs) exhibit highly conserved activation and signaling mechanisms by which agonist stimulation leads to coupling of heterotrimeric G proteins and generation of second messenger response. This is followed by r…