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View article: Label-free protein-structure-sensitive live-cell microscopy for patient-specific assessment of myeloma therapy
Label-free protein-structure-sensitive live-cell microscopy for patient-specific assessment of myeloma therapy Open
The efficacy of drug therapy in multiple myeloma is conventionally assessed by whole-cell-population methods, serum analysis of light chains and monoclonal antibodies, immunofixation electrophoresis, or by flow cytometry of bone marrow asp…
View article: Protein-structure-sensitive mid-infrared optoacoustic microscopy enables label-free assessment of drug therapy in myeloma cells
Protein-structure-sensitive mid-infrared optoacoustic microscopy enables label-free assessment of drug therapy in myeloma cells Open
Conventional live-cell optical microscopy lacks sensitivity and specificity for label-free detection of intracellular protein-structure dynamics, such as conformational transition from α-helix to β-sheet. Detecting intermolecular β-sheet f…
View article: NF-κB c-REL-OTUD4 axis regulates B-cell receptor in B-cell lymphoma
NF-κB c-REL-OTUD4 axis regulates B-cell receptor in B-cell lymphoma Open
Summary The B-cell receptor (BCR) is essential for B-cell development and a crucial clinical target in immuno-oncology. However, therapeutic success against the BCR and downstream signaling pathways is hampered by enhanced NF-κB activation…
View article: c-Rel gain in B cells drives germinal center reactions and autoantibody production
c-Rel gain in B cells drives germinal center reactions and autoantibody production Open
Single-nucleotide polymorphisms and locus amplification link the NF-κB transcription factor c-Rel to human autoimmune diseases and B cell lymphomas, respectively. However, the functional consequences of enhanced c-Rel levels remain enigmat…