Esmaeil Mirzaei
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View article: A collagen-based bilayer nanocomposite scaffold for osteochondral tissue regeneration: integrating hydroxyapatite and cellulose nanocrystals
A collagen-based bilayer nanocomposite scaffold for osteochondral tissue regeneration: integrating hydroxyapatite and cellulose nanocrystals Open
Regenerating osteochondral (OC) defects remains a significant challenge in regenerative medicine due to the complex nature of these tissues and their limited self-healing capacity. While tissue engineering offers a promising solution, deve…
View article: Piperine-loaded mesoporous silica nanoparticles as a promising strategy for targeting Echinococcus granulosus protoscoleces
Piperine-loaded mesoporous silica nanoparticles as a promising strategy for targeting Echinococcus granulosus protoscoleces Open
Medical and surgical treatments for cystic echinococcosis (CE) are challenged by various complications. This study evaluates in vitro protoscolicidal activity of piperine-loaded mesoporous silica nanoparticles (PIP-MSNs) against protoscole…
View article: Study of MIC of silver and zinc oxide nanoparticles, strong and cost-effective antibacterial against biofilm-producing Acinetobacter baumannii in Shiraz, Southwest of Iran
Study of MIC of silver and zinc oxide nanoparticles, strong and cost-effective antibacterial against biofilm-producing Acinetobacter baumannii in Shiraz, Southwest of Iran Open
View article: Evaluation of the Spatial Arrangement of Rabbit Hepatocytes Based on Voronoi Tessellation Following Exposure to Zinc Oxide Nanoparticles
Evaluation of the Spatial Arrangement of Rabbit Hepatocytes Based on Voronoi Tessellation Following Exposure to Zinc Oxide Nanoparticles Open
Background: Zinc oxide nanoparticles have been utilized in different fields over the last decades. These nanoparticles can pose significant risks to various organs such as the liver. This study aimed to evaluate the effects of zinc oxide n…
View article: Nanotechnology improves the detection of bacteria: Recent advances and future perspectives
Nanotechnology improves the detection of bacteria: Recent advances and future perspectives Open
Nanotechnology has advanced significantly, particularly in biomedicine, showing promise for nanomaterial applications. Bacterial infections pose persistent public health challenges due to the lack of rapid pathogen detection methods, resul…
View article: Evaluation of the restorative effect of ozone and chitosan–hyaluronic acid with and without mesenchymal stem cells on wound healing in rats
Evaluation of the restorative effect of ozone and chitosan–hyaluronic acid with and without mesenchymal stem cells on wound healing in rats Open
This study evaluated the effect of ozone, chitosan–hyaluronic (Cs–HA) acid and mesenchymal stem cells (MSCs) on wound healing in rats. A total of 64 rats were randomly divided into four groups: control, ozone, Cs–HA + ozone and Cs–HA + ozo…
View article: Development of antibacterial collagen membranes with optimal silver nanoparticle content for periodontal regeneration
Development of antibacterial collagen membranes with optimal silver nanoparticle content for periodontal regeneration Open
The effective control of pathogenic bacteria is crucial in the restoration of periodontal tissue affected by periodontitis. Guided tissue regeneration (GTR) membranes are commonly used to aid in the repair of periodontal defects. Therefore…
View article: Determining the cytotoxicity of the Minimum Inhibitory Concentration (MIC) of silver and zinc oxide nanoparticles in ESBL and carbapenemase producing Proteus mirabilis isolated from clinical samples in Shiraz, Southwest Iran
Determining the cytotoxicity of the Minimum Inhibitory Concentration (MIC) of silver and zinc oxide nanoparticles in ESBL and carbapenemase producing Proteus mirabilis isolated from clinical samples in Shiraz, Southwest Iran Open
View article: Novel Polycaprolactone‐Chitosan Hybrid Scaffold: A Double‐Sided Hernia Mesh for Regeneration of Abdominal Wall Defects with Minimized Adverse Adhesions
Novel Polycaprolactone‐Chitosan Hybrid Scaffold: A Double‐Sided Hernia Mesh for Regeneration of Abdominal Wall Defects with Minimized Adverse Adhesions Open
Front cover: Celebrating innovation in hernia repair, article 2300286 by Esmaeil Mirzaei and co-workers introduces a pioneering double-faced mesh design using electrospun polycaprolactone fibers (PCL) and chitosan nanofibers (CS). This mem…
View article: Isolation of B Cells Using Silane‐Coated Magnetic Nanoparticles
Isolation of B Cells Using Silane‐Coated Magnetic Nanoparticles Open
One of the most important advantages and applications of coated nanoparticles in biological applications is their use in isolating different types of cells to diagnose and treat all types of diseases. Therefore, in this research work, the …
View article: Finding a Proper Valproic Acid-Based Autism Spectrum Disorder Model in Zebrafish: Early and Long-term Neurobehavioral Studies
Finding a Proper Valproic Acid-Based Autism Spectrum Disorder Model in Zebrafish: Early and Long-term Neurobehavioral Studies Open
Background: Valproic acid (VPA), which is often used to treat epilepsy, causes a variety of neurobehavioral impairments that closely resemble the phenotype of autism spectrum disorder (ASD) in prenatally exposed individuals. Although the n…
View article: Novel Polycaprolactone‐Chitosan Hybrid Scaffold: A Double‐Sided Hernia Mesh for Regeneration of Abdominal Wall Defects with Minimized Adverse Adhesions
Novel Polycaprolactone‐Chitosan Hybrid Scaffold: A Double‐Sided Hernia Mesh for Regeneration of Abdominal Wall Defects with Minimized Adverse Adhesions Open
As an alternative for currently available hernia meshes, electrospun scaffolds represent good biocompatibility and favorable healing performance. However, they usually cannot meet the minimum mechanical requirements for a successful hernia…
View article: Surface modification of polycaprolactone nanofibers through hydrolysis and aminolysis: a comparative study on structural characteristics, mechanical properties, and cellular performance
Surface modification of polycaprolactone nanofibers through hydrolysis and aminolysis: a comparative study on structural characteristics, mechanical properties, and cellular performance Open
View article: Fabrication of nanofibrous mat surrounded hydrogel scaffold as an encapsulation device for encapsulating pancreas β cells
Fabrication of nanofibrous mat surrounded hydrogel scaffold as an encapsulation device for encapsulating pancreas β cells Open
View article: Nanosilibinin ameliorates anxiety, learning impairment and Wnt-β catenin related genes expression deficits in zebrafish model of Autism Spectrum Disorder
Nanosilibinin ameliorates anxiety, learning impairment and Wnt-β catenin related genes expression deficits in zebrafish model of Autism Spectrum Disorder Open
purpose The present study evaluated the effect of Nanosilibinin (as an inhibitor of Wnt signaling pathway), on neurobehavioral and molecular deficits in Valproic acid zebrafish model of Autism Spectrum Disorder. Methods Zebrafish embryos w…
View article: Optimization of Synthesis Conditions of <i>β</i>‐FeOOH Nanorods towards Antimicrobial Benefits
Optimization of Synthesis Conditions of <i>β</i>‐FeOOH Nanorods towards Antimicrobial Benefits Open
FeOOH nanoparticles have recently appealed to wide‐ranging applications due to their physicochemical properties and size‐tunable synthesis; however, a few studies were performed on the antimicrobial potentials of iron oxyhydroxide nanopart…
View article: Nano Iron Oxide-PCL Composite as an Improved Soft Tissue Scaffold
Nano Iron Oxide-PCL Composite as an Improved Soft Tissue Scaffold Open
Iron oxide nanoparticles were employed to fabricate a soft tissue scaffold with enhanced physicochemical and biological characteristics. Growth promotion effect of L-lysine coated magnetite (Lys@Fe3O4) nanoparticles on the liver cell lines…
View article: A New and Simple Method for Spinal Cord Injury Induction in Mice
A New and Simple Method for Spinal Cord Injury Induction in Mice Open
Introduction: Spinal Cord Injury (SCI) is a devastating disease with poor clinical outcomes. Animal models provide great opportunities to expand our horizons in identifying SCI pathophysiological mechanisms and introducing effective treatm…
View article: Author response for "Local Delivery of Fingolimod through PLGA Nanoparticles and PuraMatrix‐ Embedded Neural Precursor Cells Promote Motor Function Recovery and Tissue Repair in Spinal Cord Injury"
Author response for "Local Delivery of Fingolimod through PLGA Nanoparticles and PuraMatrix‐ Embedded Neural Precursor Cells Promote Motor Function Recovery and Tissue Repair in Spinal Cord Injury" Open
View article: Bio-Assisted Synthesis of Food-Grade FeOOH Nanoellipsoids as Promising Iron Supplements for Food Fortification
Bio-Assisted Synthesis of Food-Grade FeOOH Nanoellipsoids as Promising Iron Supplements for Food Fortification Open
Background and Objective: Nanostructures of FeOOH are approved substitutions for iron salts in treatment of iron deficiencies. These particles can be promising additives to develop iron fortified foods. Researchers are interested to develo…
View article: In vitro evaluation of albendazole nanocrystals against Echinococcus granulosus protoscolices.
In vitro evaluation of albendazole nanocrystals against Echinococcus granulosus protoscolices. Open
Echinococcus granulosus is a zoonotic parasite causing hydatidosis in humans and animals. This study has been done in order to investigate the effect of albendazole nanocrystals on the viability of E. granulosus protoscolices. The average …
View article: Effects of Dextran-Coated Superparamagnetic Iron Oxide Nanoparticles on Mouse Embryo Development, Antioxidant Enzymes and Apoptosis Genes Expression, and Ultrastructure of Sperm, Oocytes and Granulosa Cells.
Effects of Dextran-Coated Superparamagnetic Iron Oxide Nanoparticles on Mouse Embryo Development, Antioxidant Enzymes and Apoptosis Genes Expression, and Ultrastructure of Sperm, Oocytes and Granulosa Cells. Open
There is considerable concern regarding D-SPIONs toxic effects on IVF, and mitochondrial and cell membrane damage in mouse spermatozoa and oocytes, which may be related to oxidative stress and apoptotic events.
View article: Simple and Robust Fabrication and Characterization of Conductive Carbonized Nanofibers Loaded with Gold Nanoparticles for Bone Tissue Engineering Applications
Simple and Robust Fabrication and Characterization of Conductive Carbonized Nanofibers Loaded with Gold Nanoparticles for Bone Tissue Engineering Applications Open
Bone tissue engineering is a new and applicable emerging approach to repair the bone defects. In this regard, designing and robust fabrication of tissue engineering scaffolds that could provide an appropriate environment for cell prolifera…
View article: Propagation of limbal stem cells on polycaprolactone and polycaprolactone/gelatin fibrous scaffolds and transplantation in animal model
Propagation of limbal stem cells on polycaprolactone and polycaprolactone/gelatin fibrous scaffolds and transplantation in animal model Open
Introduction: This study was conducted to compare the effect of nanofibrous polycaprolactone (PCL) and PCL/gelatin (PCL/Gel) on limbal epithelial stem cell (LESC) and its efficiency for transplantation in animal model. Methods…
View article: Chitosan-based layered nanofibers loaded with herbal extract as wound-dressing materials on wound model studies
Chitosan-based layered nanofibers loaded with herbal extract as wound-dressing materials on wound model studies Open
In the present study, multilayer electrospun chitosan-based dressing containing Semellil extract (ANGIPARS ™) was fabricated and evaluated as wound dressing. The first layer was polyurethane nanofibers which used as a protective layer, the…
View article: Sensory and Motor Behavior Evidences Supporting the Usefulness of Conditioned Medium from Dental Pulp-Derived Stem Cells in Spinal Cord Injury in Rats
Sensory and Motor Behavior Evidences Supporting the Usefulness of Conditioned Medium from Dental Pulp-Derived Stem Cells in Spinal Cord Injury in Rats Open
Intraspinal administration of SHED-CM loaded in collagen hydrogel leads to improved functional recovery and proposes a cell-free therapeutic approach for SCI.
View article: Evaluating the effect of pH on mechanical strength and cell compatibility of nanostructured collagen hydrogel by the plastic compression method
Evaluating the effect of pH on mechanical strength and cell compatibility of nanostructured collagen hydrogel by the plastic compression method Open
Objective(s): One of the main constraints of collagen hydrogel scaffolds for using in tissue engineering is mechanical weakness. Plastic compression (PC) is a physical method to overcome the mechanical limitation of collagen hydrogel. Mate…
View article: Nanofibrillated chitosan/polycaprolactone bionanocomposite scaffold with improved tensile strength and cellular behavior
Nanofibrillated chitosan/polycaprolactone bionanocomposite scaffold with improved tensile strength and cellular behavior Open
Objective(s): Fabrication of scaffolds with improved mechanical properties and favorable cellular compatibility is crucial for many tissue engineering applications. This study was aimed to improve mechanical and biological properties of po…
View article: Polyethylenimine-based nanocarriers in co-delivery of drug and gene: a developing horizon
Polyethylenimine-based nanocarriers in co-delivery of drug and gene: a developing horizon Open
The meaning of gene therapy is the delivery of DNA or RNA to cells for the treatment or prevention of genetic disorders. The success rate of gene therapy depends on the progression and safe gene delivery system. The vectors available for g…