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View article: Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response
Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response Open
Oncogenic driver mutations are common in normal tissues, indicating that non-genetic factors are necessary for tumorigenesis. Phenotypic plasticity is a crucial gateway to malignancy, and inflammation can fuel tumorigenesis; however, littl…
View article: The Androgen Receptor and MYC synergise to modulate the synthesis of Siglec-7 ligands in prostate cancer
The Androgen Receptor and MYC synergise to modulate the synthesis of Siglec-7 ligands in prostate cancer Open
Glyco-immune checkpoints have recently been shown to be critical mediators of immunotherapy resistance across multiple cancer types. In clinical trials, immunotherapeutic treatments for prostate cancer have failed to elicit durable clinica…
View article: N-terminal protein-macrocycles enabled by conjugate addition/ring expansion cascade reactions
N-terminal protein-macrocycles enabled by conjugate addition/ring expansion cascade reactions Open
Site selective protein modification is a vital tool in chemical biology and associated biomedical research. In this manuscript, simple, easy-to-prepare acryloyl imides are revealed as novel reagents for selective N-terminal protein bioconj…
View article: A general and accessible approach to enrichment and characterisation of natural anti-Neu5Gc antibodies from human samples
A general and accessible approach to enrichment and characterisation of natural anti-Neu5Gc antibodies from human samples Open
N-glycolylneuraminic acid (Neu5Gc) is a non-human sialic acid which is presented on the surface of human cells following uptake from dietary sources. This is widely hypothesised to drive the production of anti-Neu5Gc antibodies, which have…
View article: A general and accessible approach to enrichment and characterisation of natural anti-Neu5Gc antibodies from human samples
A general and accessible approach to enrichment and characterisation of natural anti-Neu5Gc antibodies from human samples Open
A workflow to enrich and detect anti-Neu5Gc antibodies from individual plasma specimens, using CMAH-transfected human cells as a source of Neu5Gc-containing glycans.
View article: A systematic review reveals conflicting evidence for the prevalence of antibodies against the sialic acid ‘xenoautoantigen’ Neu5Gc in humans and the need for a standardised approach to quantification
A systematic review reveals conflicting evidence for the prevalence of antibodies against the sialic acid ‘xenoautoantigen’ Neu5Gc in humans and the need for a standardised approach to quantification Open
Despite an array of hypothesised implications for health, disease, and therapeutic development, antibodies against the non-human sialic acid N -glycolylneuraminic acid (Neu5Gc) remain a subject of much debate. This systematic review of 114…
View article: Oncogenic RAS drives rapid onset cellular plasticity and elicits a tumour-promoting neutrophil response at the inception of preneoplastic development
Oncogenic RAS drives rapid onset cellular plasticity and elicits a tumour-promoting neutrophil response at the inception of preneoplastic development Open
To date, very little is known regarding the earliest cellular and molecular events within the initial preneoplastic cell (PNC) niche that might determine the outcome of PNC development. Here, we combine in vivo live imaging and single cell…