Esra Dirimtekin
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View article: Perineural Invasion in Pancreatic Ductal Adenocarcinoma: Recapitulating Its Importance and Defining Future Directions
Perineural Invasion in Pancreatic Ductal Adenocarcinoma: Recapitulating Its Importance and Defining Future Directions Open
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, mainly due to its aggressive nature, early metastasis, diagnosis at late stages, and limited response to systemic anticancer therapy. Perineural invasion …
View article: A family of LBR biallelic pathogenic variants resulting in rhizomelic skeletal dysplasia with pelger-huet anomaly
A family of LBR biallelic pathogenic variants resulting in rhizomelic skeletal dysplasia with pelger-huet anomaly Open
Introduction: The LBR gene has two primary functions: maintaining the structural integrity of the nuclear envelope and playing a role in cholesterol biosynthesis. Heterozygous variants in the LBR gene have been associated with PelgerHuët a…
View article: BRCA Mutations and MicroRNA Expression Patterns in the Peripheral Blood of Breast Cancer Patients
BRCA Mutations and MicroRNA Expression Patterns in the Peripheral Blood of Breast Cancer Patients Open
Breast cancer (BC) persists as the predominant malignancy globally, standing as the foremost cause of cancer-related mortality among women. Despite notable advancements in prevention and treatment, encompassing the incorporation of targete…
View article: miR-34a-FOXP1 Loop in Ovarian Cancer
miR-34a-FOXP1 Loop in Ovarian Cancer Open
Ovarian cancer (OC) is the main cause of gynecological cancer mortality in most developed countries. microRNA (miR) expression dysregulation has been highlighted in human cancers, and miR-34a is found to be downregulated and associated wit…