Estebán Martínez
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View article: Incidence, Clinical Features and Vaccination Coverage of Pneumococcal Disease in People Living with HIV: A Retrospective Cohort Study (2015–2024)
Incidence, Clinical Features and Vaccination Coverage of Pneumococcal Disease in People Living with HIV: A Retrospective Cohort Study (2015–2024) Open
Introduction: The incidence of pneumococcal disease (PD) in people living with HIV (PLWH) is higher than in the general population; therefore, this study aimed to analyze its incidence, clinical characteristics and vaccination coverage in …
View article: Integrase versus protease inhibitor therapy in advanced HIV disease (LAPTOP): a multicountry, randomised, open-label, non-inferiority trial
Integrase versus protease inhibitor therapy in advanced HIV disease (LAPTOP): a multicountry, randomised, open-label, non-inferiority trial Open
Gilead Sciences and Janssen Pharmaceuticals.
View article: Major revision version 13.0 of the European <scp>AIDS</scp> Clinical Society guidelines 2025
Major revision version 13.0 of the European <span>AIDS</span> Clinical Society guidelines 2025 Open
Background The European AIDS Clinical Society (EACS) guidelines were revised for the 21st time in 2025, with updates covering all aspects of HIV care. Key Points of the Guidelines Update The structure of the guidelines has been reorganized…
View article: Risk Assessment in a Global CVD Prevention Cohort of People With HIV by PCE, PREVENT, and SCORE2
Risk Assessment in a Global CVD Prevention Cohort of People With HIV by PCE, PREVENT, and SCORE2 Open
Background REPRIEVE findings catalyzed changes to multiple guidelines directing statin therapy prescribing for people with HIV (PWH). US guidelines use the pooled cohort equation (PCE)-derived 10-year atherosclerotic cardiovascular disease…
View article: Morbidity and risk factors of <scp>COVID</scp> ‐19 in people with <scp>HIV</scp> ‐1 in Europe: A combined observational cohort and nested case–control study
Morbidity and risk factors of <span>COVID</span> ‐19 in people with <span>HIV</span> ‐1 in Europe: A combined observational cohort and nested case–control study Open
Objective To study the COVID‐19 disease course in people living with HIV (PLWH) based on meaningful case numbers, information about comorbidities, antiretroviral and COVID‐19 treatment and HIV disease‐related variables. Methods Multi‐centr…
View article: Long-Term Health Outcomes of People with HIV Engaged in Chemsex: A Prospective Cohort Study on Drug Use, Sexual Behaviour, Sexually-Transmitted Infections and Vulnerability
Long-Term Health Outcomes of People with HIV Engaged in Chemsex: A Prospective Cohort Study on Drug Use, Sexual Behaviour, Sexually-Transmitted Infections and Vulnerability Open
Chemsex incidence and syphilis rates declined, but persistent high-risk behaviours, subgroup vulnerabilities, and increasing demand for sexuality-related assistance require targeted interventions and comprehensive support.
View article: Establishing shared definitions of virological failure and discontinuation for long-acting injectable cabotegravir and rilpivirine therapy (the CONSENSUS-LAI Study): an international survey and Delphi process
Establishing shared definitions of virological failure and discontinuation for long-acting injectable cabotegravir and rilpivirine therapy (the CONSENSUS-LAI Study): an international survey and Delphi process Open
ViiV Healthcare.
View article: Hypertension and blood pressure changes with dolutegravir or comparator antiretroviral therapy in randomized trials through 96 weeks
Hypertension and blood pressure changes with dolutegravir or comparator antiretroviral therapy in randomized trials through 96 weeks Open
Background To date, there are limited published data from randomized trials evaluating the effects of integrase strand transfer inhibitor-based regimens, including dolutegravir-based antiretroviral therapy (ART), on blood pressure (BP) in …
View article: Traumatic Events and Post-Traumatic Stress Disorder in Adolescents with Severe Eating Disorder Admitted to a Day Care Hospital
Traumatic Events and Post-Traumatic Stress Disorder in Adolescents with Severe Eating Disorder Admitted to a Day Care Hospital Open
Background: It is common for patients with eating disorders (ED) to report traumatic experiences early in their lifetime. The objective of this study was to explore the presence and types of traumatic events and the comorbidity with Post-T…
View article: Epidemiology of Aspergillosis Diagnoses in the U.S. using a National EHR Database, 2013-2023
Epidemiology of Aspergillosis Diagnoses in the U.S. using a National EHR Database, 2013-2023 Open
Importance Aspergillosis is an under-recognized fungal infection associated with rising hospitalizations, concerns about antifungal resistance, and substantial morbidity and mortality in the U.S. Yet, national data on aspergillosis remain …
View article: Factors Affecting Risk of Cardiovascular Disease (CVD) Events in a Global CVD Prevention Cohort of People With Human Immunodeficiency Virus (HIV)
Factors Affecting Risk of Cardiovascular Disease (CVD) Events in a Global CVD Prevention Cohort of People With Human Immunodeficiency Virus (HIV) Open
Background Persons with HIV face increased risks of major adverse cardiovascular events (MACE), partially mitigated by statin therapy. Methods We characterized factors associated with MACE and MACE subcomponents among PWH enrolled in REPRI…
View article: HIV-Tat upregulates the expression of senescence biomarkers in CD4+ T-cells
HIV-Tat upregulates the expression of senescence biomarkers in CD4+ T-cells Open
Introduction Current antiretroviral therapy (ART) for HIV infection reduces plasma viral loads to undetectable levels and has increased the life expectancy of people with HIV (PWH). However, this increased lifespan is accompanied by signs …
View article: Could reduced dosing maintain more people on antiretrovirals after the sudden cuts in USAID funding? A crisis response
Could reduced dosing maintain more people on antiretrovirals after the sudden cuts in USAID funding? A crisis response Open
Antiretroviral therapy shortages caused by sudden and severe cuts in USAID and PEPFAR have focused attention on strategies to extend antiretroviral supplies and mitigate this crisis. Efficacy data are now available from seven randomized co…
View article: Impact of training healthcare professionals in the detection and management of neuropsychiatric comorbidities in people with <scp>HIV</scp>: The <scp>CONECTAR</scp> project in <scp>Spain</scp>
Impact of training healthcare professionals in the detection and management of neuropsychiatric comorbidities in people with <span>HIV</span>: The <span>CONECTAR</span> project in <span>Spain</span> Open
Introduction Although anxiety, depression and insomnia in people with HIV (PWH) are prevalent and have a major impact on clinical outcomes and quality of life, physicians fail to evaluate them routinely. The CONECTAR Project [Neuropsychiat…
View article: Burden of liver steatosis and liver fibrosis in a large cohort of people living with <scp>HIV</scp>
Burden of liver steatosis and liver fibrosis in a large cohort of people living with <span>HIV</span> Open
Background Liver steatosis (LS) and liver fibrosis (LF) can increase the risk of cardiovascular disease in people with HIV, but their prevalence and associated factors are poorly understood. This study aimed to assess the prevalence of and…
View article: Prevalence, risk factors and the impact of tenofovir treatment in SARS-CoV-2 infection and COVID-19 disease among people living with HIV: A cross-sectional population-based study
Prevalence, risk factors and the impact of tenofovir treatment in SARS-CoV-2 infection and COVID-19 disease among people living with HIV: A cross-sectional population-based study Open
Ongoing surveillance and tailored interventions are crucial for at-risk PWH amid evolving SARS-CoV-2 variants. Tenofovir did not prevent SARS-CoV-2 infection or COVID-19.
View article: Effects of Pitavastatin on COVID-19 Incidence and Seriousness Among a Global Cohort of People With HIV
Effects of Pitavastatin on COVID-19 Incidence and Seriousness Among a Global Cohort of People With HIV Open
Background Among people with HIV (PWH), COVID-19 is common and potentially severe. We leveraged REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) to assess the effects of statin therapy for cardiovascular disease prevention on …
View article: Blood Parameters in Children and Adolescents With Underweight and Atypical Anorexia Nervosa
Blood Parameters in Children and Adolescents With Underweight and Atypical Anorexia Nervosa Open
Objective This study aimed to identify biochemical, hematological, and endocrinological abnormalities in a sample of children and adolescents with underweight AN and atypical AN and to compare these results between the two groups. Method B…
View article: Metabolic, Mitochondrial, and Inflammatory Effects of Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate in Asymptomatic Antiretroviral-Naïve People with HIV
Metabolic, Mitochondrial, and Inflammatory Effects of Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate in Asymptomatic Antiretroviral-Naïve People with HIV Open
This study aimed to comprehensively assess the metabolic, mitochondrial, and inflammatory effects of first-line efavirenz, emtricitabine, and tenofovir disoproxil fumarate (EFV/FTC/TDF) single-tablet regimen (STR) relative to untreated asy…
View article: Rapid initiation of bictegravir/emtricitabine/tenofovir alafenamide as first-line therapy in HIV infection. A prospective study
Rapid initiation of bictegravir/emtricitabine/tenofovir alafenamide as first-line therapy in HIV infection. A prospective study Open
Introduction Rapid initiation of ART after HIV diagnosis is recommended for individual and public health benefits. However, certain clinical and ART-related considerations hinder immediate initiation of therapy. Methods An open-label, sing…
View article: Early Detection of Cancer and Precancerous Lesions in Persons With HIV Through a Comprehensive Cancer Screening Protocol
Early Detection of Cancer and Precancerous Lesions in Persons With HIV Through a Comprehensive Cancer Screening Protocol Open
Background Non-AIDS defining malignancies present a growing challenge for persons with human immunodeficiency virus (HIV, PWH), yet tailored interventions for timely cancer diagnosis are lacking. The Spanish IMPAC-Neo protocol was designed…
View article: Considerations on the Associations Between Antiretroviral Regimen and Changes in Blood Pressure in the D2EFT Study
Considerations on the Associations Between Antiretroviral Regimen and Changes in Blood Pressure in the D2EFT Study Open
Journal Article Accepted manuscript Considerations on the associations between antiretroviral regimen and changes in blood pressure in the D2EFT study Get access Esteban Martinez Esteban Martinez Hospital Clínic-IDIBAPS, Barcelona, SpainUn…
View article: Effectiveness, safety and discontinuation rates of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) in people with HIV using real-world data: a systematic review and meta-analysis
Effectiveness, safety and discontinuation rates of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) in people with HIV using real-world data: a systematic review and meta-analysis Open
Background The use of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) is based on the results of robust clinical trials. Objectives To assess the effectiveness and safety of BIC/FTC/TAF in treatment-naïve (TN) and treatment-e…