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View article: Engineered Whey Protein Nanoparticles for Intracellular Drug Delivery
Engineered Whey Protein Nanoparticles for Intracellular Drug Delivery Open
Protein-based nanoparticles, composed of water-soluble proteins, represent a promising platform for reducing side effects during drug delivery. They enhance the solubility, stability, and bioavailability of hydrophobic therapeutic agents w…
View article: Lipidomic analysis of differently prepared platelet concentrates in additive solution during storage.
Lipidomic analysis of differently prepared platelet concentrates in additive solution during storage. Open
The expression of LPC and some eicosanoids in BCs could be used as novel biomarkers of PC quality. Future studies are needed to explore their impact on adverse transfusion reactions.
View article: Bioactive lipids as biomarkers of adverse reactions associated with apheresis platelet concentrate transfusion
Bioactive lipids as biomarkers of adverse reactions associated with apheresis platelet concentrate transfusion Open
Platelet concentrate (PC) transfusion seeks to provide haemostasis in patients presenting severe central thrombocytopenia or severe bleeding. PCs may induce adverse reactions (AR) that can occasionally be severe (SAR). PCs contain active b…
View article: YAP promotes cell-autonomous immune responses to tackle intracellular Staphylococcus aureus in vitro
YAP promotes cell-autonomous immune responses to tackle intracellular Staphylococcus aureus in vitro Open
View article: YAP promotes cell-autonomous immune responses to tackle intracellular<i>Staphylococcus aureus in vitro</i>
YAP promotes cell-autonomous immune responses to tackle intracellular<i>Staphylococcus aureus in vitro</i> Open
Transcriptional cofactors YAP/TAZ have recently been found to support autophagy and inflammation, which are part of cell autonomous immunity and are critical in antibacterial defense. Here, we studied the role of YAP against Staphylococcus…
View article: Platelets as Key Factors in Inflammation: Focus on CD40L/CD40
Platelets as Key Factors in Inflammation: Focus on CD40L/CD40 Open
Platelets are anucleate cytoplasmic fragments derived from the fragmentation of medullary megakaryocytes. Activated platelets adhere to the damaged endothelium by means of glycoproteins on their surface, forming the platelet plug. Activate…
View article: Comparison of bacterial filtration efficiency vs. particle filtration efficiency to assess the performance of non-medical face masks
Comparison of bacterial filtration efficiency vs. particle filtration efficiency to assess the performance of non-medical face masks Open
As a result of the current COVID-19 pandemic, the use of facemasks has become commonplace. The performance of medical facemasks is assessed using Bacterial Filtration Efficiency (BFE) tests. However, as BFE tests, require specific expertis…
View article: YAP/TAZ: Key Players for Rheumatoid Arthritis Severity by Driving Fibroblast Like Synoviocytes Phenotype and Fibro-Inflammatory Response
YAP/TAZ: Key Players for Rheumatoid Arthritis Severity by Driving Fibroblast Like Synoviocytes Phenotype and Fibro-Inflammatory Response Open
Objective The role of YAP/TAZ, two transcriptional co-activators involved in several cancers, was investigated in rheumatoid arthritis (RA). Methods Fibroblast like synoviocytes (FLS) from patients with RA or osteoarthritis were cultured i…
View article: In vitro study of the molecular determinants involved in autophagic response during Staphylococcus aureus infection
In vitro study of the molecular determinants involved in autophagic response during Staphylococcus aureus infection Open
Staphylococcus aureus est une bactérie pathogène et commensale de l’Homme capable de déclencher son internalisation dans des cellules phagocytaires non professionnelles (NPPCs). La présence de S. aureus provoque une réponse autophagique ra…
View article: Comparison of Bacterial Filtration Efficiency vs. Particle Filtration Efficiency to Assess the Performance of Non-Medical Face Masks in the Emergency Context of COVID-19 Pandemic
Comparison of Bacterial Filtration Efficiency vs. Particle Filtration Efficiency to Assess the Performance of Non-Medical Face Masks in the Emergency Context of COVID-19 Pandemic Open
As a result of the current COVID-19 pandemic, the use of facemasks has become commonplace. The performance of medical facemasks is assessed using Bacterial Filtration Efficiency (BFE) tests. However, as BFE tests, require specific expertis…
View article: Improved Enzyme Protection Assay to Study <em>Staphylococcus aureus</em> Internalization and Intracellular Efficacy of Antimicrobial Compounds
Improved Enzyme Protection Assay to Study <em>Staphylococcus aureus</em> Internalization and Intracellular Efficacy of Antimicrobial Compounds Open
Staphylococcus aureus expresses virulence factors to trigger its internalization into eukaryote cells and to survive inside different subcellular compartments. This paper describes an enzyme protection assay to study the extent of S. aureu…
View article: Evaluation of in vitro activity of copper gluconate against SARS-CoV-2 using confocal microscopy-based high content screening
Evaluation of in vitro activity of copper gluconate against SARS-CoV-2 using confocal microscopy-based high content screening Open
View article: Lysosomal alkalization to potentiate eradication of intra-osteoblastic Staphylococcus aureus in the bone and joint infection setting
Lysosomal alkalization to potentiate eradication of intra-osteoblastic Staphylococcus aureus in the bone and joint infection setting Open
View article: New insights into the standard method of assessing bacterial filtration efficiency of medical face masks
New insights into the standard method of assessing bacterial filtration efficiency of medical face masks Open
Based on the current knowledge of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) transmission, wearing a mask has been recommended during the COVID-19 pandemic. Bacterial filtration efficiency (BFE) measurements enable design…
View article: Evaluation of effectiveness and compliance with the mupirocin nasal ointment part of Staphylococcus aureus decolonization in real life using UPLC-MS/MS mupirocin quantification
Evaluation of effectiveness and compliance with the mupirocin nasal ointment part of Staphylococcus aureus decolonization in real life using UPLC-MS/MS mupirocin quantification Open
Background Preoperative decolonization is recommended in Staphylococcus aureus nasal carriers scheduled for cardiac surgery. We aimed to evaluate the effectiveness of and compliance with mupirocin use in nasal S. aureus carriers in a real-…
View article: Construction and validation of EGFP-expressing<i>Staphylococcus aureus</i>clinical strains for adhesion and internalization assays on epithelial cells
Construction and validation of EGFP-expressing<i>Staphylococcus aureus</i>clinical strains for adhesion and internalization assays on epithelial cells Open
Background Staphylococcus aureus is both a major pathogen and a commensal bacterium in humans. It is able to adhere at the surface of epithelial cells of the anterior nares and can trigger its internalization inside these non-professional …