Estelle B. Gauda
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View article: Characteristics, triggers, treatments, and experimental models of neonatal acute respiratory distress syndrome
Characteristics, triggers, treatments, and experimental models of neonatal acute respiratory distress syndrome Open
Neonatal acute respiratory distress syndrome (NARDS) is a severe and potentially life-threatening form of lung injury recently defined by the International Neonatal ARDS Consensus. It is marked by extensive lung inflammation and damage to …
View article: L-Citrulline in Neonates: From Bench to Bed Side
L-Citrulline in Neonates: From Bench to Bed Side Open
L-citrulline (L-CIT), a precursor to L-arginine (L-ARG), is a key contributor to the nitric oxide (NO) signaling pathway. Endothelial dysfunction, characterized by deficient nitric oxide synthesis, is implicated in the pathogenesis of vari…
View article: Cardiorespiratory Monitoring Data to Predict Respiratory Outcomes in Extremely Preterm Infants
Cardiorespiratory Monitoring Data to Predict Respiratory Outcomes in Extremely Preterm Infants Open
Rationale: Immature control of breathing is associated with apnea, periodic breathing, intermittent hypoxemia, and bradycardia in extremely preterm infants. However, it is not clear if such events independently predict worse respiratory ou…
View article: SARS-CoV-2 Infection of Young Infants during the Omicron Wave: A Case Series
SARS-CoV-2 Infection of Young Infants during the Omicron Wave: A Case Series Open
We describe the clinical course of 4 infants infected with severe acute respiratory syndrome coronavirus 2. All were admitted to our tertiary care neonatal intensive care unit during the Omicron variant wave in our region. All 4 infants, w…
View article: PGC-1α activity and mitochondrial dysfunction in preterm infants
PGC-1α activity and mitochondrial dysfunction in preterm infants Open
Extremely low gestational age neonates (ELGANs) are born in a relatively hyperoxic environment with weak antioxidant defenses, placing them at high risk for mitochondrial dysfunction affecting multiple organ systems including the nervous, …
View article: Remote ischaemic conditioning in necrotising enterocolitis: a phase I feasibility and safety study
Remote ischaemic conditioning in necrotising enterocolitis: a phase I feasibility and safety study Open
Objective Remote ischaemic conditioning (RIC) improves the outcome of experimental necrotising enterocolitis (NEC) by preserving intestinal microcirculation. The feasibility and safety of RIC in preterm infants with NEC are unknown. The st…
View article: Ileal lactobezoar in extreme premature infant complicated by intestinal perforation: A case report
Ileal lactobezoar in extreme premature infant complicated by intestinal perforation: A case report Open
Lactobezoar, although rare, but numbers increased especially with the rise in numbers of extremely preterm infants worldwide, it most commonly presents later in life but in some cases, such as our case it may happen in 1st 2-3 weeks after …
View article: A preterm infant with abnormal movements
A preterm infant with abnormal movements Open
Journal Article A preterm infant with abnormal movements Get access Maria Casalino, Maria Casalino Faculty of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland Correspondence: Maria Casalino, 18010 Dufferin Street, Newmarket,…
View article: Risk factors for prolonged mechanical ventilation in neonates following gastrointestinal surgery
Risk factors for prolonged mechanical ventilation in neonates following gastrointestinal surgery Open
Lower GA and longer opioid administration were risk factors for prolonged MV in neonates following intestinal surgery. Further research is needed to investigate modifiable practices around pain assessment/ventilation in these patients, and…
View article: Adiponectin and the regulation of gastric content volume in the newborn rat
Adiponectin and the regulation of gastric content volume in the newborn rat Open
Adiponectin, a major component of breastmilk, downregulates fundic smooth muscle contraction potential, thus facilitating gastric volume accommodation. This rodent's adaptive response maximizes breastmilk intake volume after birth.
View article: Recombinant adiponectin protects the newborn rat lung from lipopolysaccharide‐induced inflammatory injury
Recombinant adiponectin protects the newborn rat lung from lipopolysaccharide‐induced inflammatory injury Open
Preterm infants are at high risk for developing bronchopulmonary dysplasia and pulmonary hypertension from inflammatory lung injury. In adult models, adiponectin (APN)-an adipocyte-derived hormone-protects the lung from inflammatory injury…
View article: A 4-week-old infant with wheezing and abnormal movements
A 4-week-old infant with wheezing and abnormal movements Open
Journal Article A 4-week-old infant with wheezing and abnormal movements Get access Marie-Pier Lirette, MBChB, Marie-Pier Lirette, MBChB Pediatric Resident, The Hospital for Sick Children, Toronto, Ontario Correspondence: Marie-Pier Lirett…
View article: Leptin: Master Regulator of Biological Functions that Affects Breathing
Leptin: Master Regulator of Biological Functions that Affects Breathing Open
Obesity is a global epidemic in developed countries accounting for many of the metabolic and cardiorespiratory morbidities that occur in adults. These morbidities include type 2 diabetes, sleep-disordered breathing (SDB), obstructive sleep…
View article: Identifying Gender Disparities and Barriers to Measuring the Status of Female Faculty: The Experience of a Large School of Medicine
Identifying Gender Disparities and Barriers to Measuring the Status of Female Faculty: The Experience of a Large School of Medicine Open
Background: Women in academic medicine are not attaining parity with men in several domains. This issue is not only one of fairness; some funding agencies are requesting data on gender benchmarking. However, most published reports on gende…
View article: Could Postnatal Age–Related Uridine Diphosphate Glucuronic Acid Be a Rate‐Limiting Factor in the Metabolism of Morphine During the First Week of Life?
Could Postnatal Age–Related Uridine Diphosphate Glucuronic Acid Be a Rate‐Limiting Factor in the Metabolism of Morphine During the First Week of Life? Open
Neonates experience dramatic changes in the disposition of drugs after birth as a result of enzyme maturation and environmental adjustment, challenging therapeutic decision making. In this research, we establish postnatal age, postmenstrua…
View article: Lipopolysaccharide exposure during the early postnatal period adversely affects the structure and function of the developing rat carotid body
Lipopolysaccharide exposure during the early postnatal period adversely affects the structure and function of the developing rat carotid body Open
The carotid body (CB) substantially influences breathing in premature infants by affecting the frequency of apnea and periodic breathing. In adult animals, inflammation alters the structure and chemosensitivity of the CB, yet it is not kno…