Estelle Dransart
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View article: Spatial N-glycan rearrangement on α5β1 integrin nucleates galectin-3 oligomers to determine endocytic fate
Spatial N-glycan rearrangement on α5β1 integrin nucleates galectin-3 oligomers to determine endocytic fate Open
Membrane glycoproteins frequently adopt different conformations when altering between active and inactive states. Here, we discover a molecular switch that exploits dynamic spatial rearrangements of N-glycans during such conformational tra…
View article: Next-generation small molecule inhibitors of clathrin function acutely inhibit endocytosis
Next-generation small molecule inhibitors of clathrin function acutely inhibit endocytosis Open
Clathrin-mediated endocytosis (CME) is the predominant endocytic pathway in eukaryotic cells and a major regulator of cell physiology as it facilitates the internalization of receptors, channels, and transporters and viral entry. The clath…
View article: Publisher Correction: Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis
Publisher Correction: Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis Open
View article: Clathrin-independent endocytosis and retrograde transport in cancer cells promote cytotoxic CD8 T cell activation
Clathrin-independent endocytosis and retrograde transport in cancer cells promote cytotoxic CD8 T cell activation Open
Endophilin A3-mediated clathrin-independent endocytosis (EndoA3-mediated CIE) mediates the internalization of immunoglobulin-like proteins, including key immune synapse components. Here, we identify ICAM1 as a novel EndoA3-dependent cargo,…
View article: Clathrin-independent endocytosis and retrograde transport in cancer cells promote cytotoxic CD8 T cell activation
Clathrin-independent endocytosis and retrograde transport in cancer cells promote cytotoxic CD8 T cell activation Open
Endophilin A3-mediated clathrin-independent endocytosis (EndoA3-mediated CIE) mediates the internalization of immunoglobulin-like proteins, including key immune synapse components. Here, we identify ICAM1 as a novel EndoA3-dependent cargo,…
View article: Clathrin-independent endocytosis and retrograde transport in cancer cells promote cytotoxic CD8 T cell activation
Clathrin-independent endocytosis and retrograde transport in cancer cells promote cytotoxic CD8 T cell activation Open
Endophilin A3-mediated clathrin-independent endocytosis (EndoA3-mediated CIE) mediates the internalization of immunoglobulin-like proteins, including key immune synapse components. Here, we identify ICAM1 as a novel EndoA3-dependent cargo,…
View article: Exploration into Galectin-3 Driven Endocytosis and Lattices
Exploration into Galectin-3 Driven Endocytosis and Lattices Open
Essentially all plasma membrane proteins are glycosylated, and their activity is regulated by tuning their cell surface dynamics. This is achieved by glycan-binding proteins of the galectin family that either retain glycoproteins within la…
View article: SLC3A2 N-glycosylation and Golgi remodeling regulate SLC7A amino acid exchangers and stress mitigation
SLC3A2 N-glycosylation and Golgi remodeling regulate SLC7A amino acid exchangers and stress mitigation Open
Proteostasis requires oxidative metabolism (ATP) and mitigation of the associated damage by glutathione, in an increasingly dysfunctional relationship with aging. SLC3A2 (4F2hc, CD98) plays a role as a disulfide-linked adaptor to the SLC7A…
View article: Spatial N-glycan rearrangement on α<sub>5</sub>β<sub>1</sub>integrin nucleates galectin-3 oligomers to determine endocytic fate
Spatial N-glycan rearrangement on α<sub>5</sub>β<sub>1</sub>integrin nucleates galectin-3 oligomers to determine endocytic fate Open
Summary Membrane glycoproteins frequently adopt different conformations when altering between active and inactive states. Here, we discover a molecular switch that exploits dynamic spatial rearrangements of N-glycans during such conformati…
View article: Growth factor-induced desialylation for the fast control of endocytosis
Growth factor-induced desialylation for the fast control of endocytosis Open
Summary It is commonly assumed that the glycan makeup of glycoproteins that reach the cell surface is final and static. Here, we challenge this notion by the discovery of a molecular switch that induces acute and reversible changes of glyc…
View article: Supplementary Figure S3 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Supplementary Figure S3 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
Combination treatment induces a long-term anti-metastatic immune response
View article: Data from Gastric Adenocarcinomas Express the Glycosphingolipid Gb<sub>3</sub>/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit
Data from Gastric Adenocarcinomas Express the Glycosphingolipid Gb<sub>3</sub>/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit Open
The B-subunit of the bacterial Shiga toxin (STxB), which is nontoxic and has low immunogenicity, can be used for tumor targeting of breast, colon, and pancreatic cancer. Here, we tested whether human gastric cancers, which are among the mo…
View article: Supplementary Figure 4 from Gastric Adenocarcinomas Express the Glycosphingolipid Gb<sub>3</sub>/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit
Supplementary Figure 4 from Gastric Adenocarcinomas Express the Glycosphingolipid Gb<sub>3</sub>/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit Open
STxB retains binding capacity to Gb3 at low pH in St3051 cells
View article: Supplementary Figure S3 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Supplementary Figure S3 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
Combination treatment induces a long-term anti-metastatic immune response
View article: Supplementary Figure 6 from Gastric Adenocarcinomas Express the Glycosphingolipid Gb<sub>3</sub>/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit
Supplementary Figure 6 from Gastric Adenocarcinomas Express the Glycosphingolipid Gb<sub>3</sub>/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit Open
The topoisomerase-inhibitor SN38 has similar effects on cell proliferation in Gb3 positive (St3051) or Gb3 negative (AGS) cells
View article: Supplementary Figure 5 from Gastric Adenocarcinomas Express the Glycosphingolipid Gb<sub>3</sub>/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit
Supplementary Figure 5 from Gastric Adenocarcinomas Express the Glycosphingolipid Gb<sub>3</sub>/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit Open
Control for specificity of intracellular uptake with control (BSA-Cy3)
View article: Supplementary Figure S5 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Supplementary Figure S5 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
NG2 and ICAM-1 staining are increased by combined treatment
View article: Supplementary Figure 1 from Gastric Adenocarcinomas Express the Glycosphingolipid Gb<sub>3</sub>/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit
Supplementary Figure 1 from Gastric Adenocarcinomas Express the Glycosphingolipid Gb<sub>3</sub>/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit Open
A) Scoring system for STxB-staining B) Gb3 detection with/without cholesterol depletion C-D) Gb3 not upregulated in gastritis
View article: Supplementary Figure S1 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Supplementary Figure S1 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
KRN7000 adjuvant or low doses irradiation does not modify tumor response
View article: Supplementary Figure S2 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Supplementary Figure S2 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
CTLA4, PD1 and Tim3 expression on CD8+ T cells is not modulated by combination treatment
View article: Supplementary Figure S2 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Supplementary Figure S2 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
CTLA4, PD1 and Tim3 expression on CD8+ T cells is not modulated by combination treatment
View article: Data from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Data from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
There is growing interest in the association of radiotherapy and immunotherapy for the treatment of solid tumors. Here, we report an extremely effective combination of local irradiation (IR) and Shiga Toxin B (STxB)–based human papillomavi…
View article: Supplementary Figure S4 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Supplementary Figure S4 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
Tumor vessels staining is not significantly affected by treatments
View article: Supplementary Figure 3 from Gastric Adenocarcinomas Express the Glycosphingolipid Gb<sub>3</sub>/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit
Supplementary Figure 3 from Gastric Adenocarcinomas Express the Glycosphingolipid Gb<sub>3</sub>/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit Open
Gb3-expression is down-regulated in senescent cancer cells (marked by SA-β-galactosidase)
View article: Data from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Data from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
There is growing interest in the association of radiotherapy and immunotherapy for the treatment of solid tumors. Here, we report an extremely effective combination of local irradiation (IR) and Shiga Toxin B (STxB)–based human papillomavi…
View article: Supplementary Figure 4 from Gastric Adenocarcinomas Express the Glycosphingolipid Gb<sub>3</sub>/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit
Supplementary Figure 4 from Gastric Adenocarcinomas Express the Glycosphingolipid Gb<sub>3</sub>/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit Open
STxB retains binding capacity to Gb3 at low pH in St3051 cells
View article: Supplementary Figure 2 from Gastric Adenocarcinomas Express the Glycosphingolipid Gb<sub>3</sub>/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit
Supplementary Figure 2 from Gastric Adenocarcinomas Express the Glycosphingolipid Gb<sub>3</sub>/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit Open
Gb3-expression during cell division and mitosis in GP220 gastric cancer cells
View article: Supplementary Figure S5 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Supplementary Figure S5 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
NG2 and ICAM-1 staining are increased by combined treatment
View article: Supplementary Tables from Gastric Adenocarcinomas Express the Glycosphingolipid Gb<sub>3</sub>/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit
Supplementary Tables from Gastric Adenocarcinomas Express the Glycosphingolipid Gb<sub>3</sub>/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit Open
Supplementary Tables: I) Gastric Carcinoma Patient Collective and Clinical Data II) Patient collective with clinically manifest gastritis III) Characteristics of cancer cell lines IV) IC50-values for gastric cancer cell lines
View article: Supplementary Figure S1 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer
Supplementary Figure S1 from Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer Open
KRN7000 adjuvant or low doses irradiation does not modify tumor response