Esten N. Vandsemb
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View article: T cell phenotype and clonality changes in myeloma patients with short overall survival
T cell phenotype and clonality changes in myeloma patients with short overall survival Open
Overall survival (OS) in multiple myeloma (MM) varies between a couple of months to more than 20 years, influenced by tumor characteristics, the tumor microenvironment (TME), and patient factors such as age and frailty. We analyzed sequent…
View article: PD-1H/VISTA mediates immune evasion in acute myeloid leukemia
PD-1H/VISTA mediates immune evasion in acute myeloid leukemia Open
Acute myeloid leukemia (AML) presents a pressing medical need in that it is largely resistant to standard chemotherapy as well as modern therapeutics, such as targeted therapy and immunotherapy, including anti-programmed cell death protein…
View article: A patient with minimal myeloma treatment who survived for 20 years
A patient with minimal myeloma treatment who survived for 20 years Open
Not available.
View article: Supplementary Figure 4 from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3
Supplementary Figure 4 from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3 Open
Densitometric quantification of Western blot bands. Each graph shows the ratio between expression of protein of interest and its GAPDH loading control for Figures 6B, 6C and 6D. The image scanner Image J was used to compare the density of …
View article: Supplementary Figure 1 from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3
Supplementary Figure 1 from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3 Open
Confirmation of transduction of INA-6 cells. PRL-3 overexpression was confirmed by A) qRT PCR and B) Immunoblotting for PRL-3. GAPDH was used as loading control. PRL-3 down regulation was confirmed by C) qRT PCR. Expression level is presen…
View article: Supplementary Figure 4 from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3
Supplementary Figure 4 from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3 Open
Densitometric quantification of Western blot bands. Each graph shows the ratio between expression of protein of interest and its GAPDH loading control for Figures 6B, 6C and 6D. The image scanner Image J was used to compare the density of …
View article: Supplementary Figure 2 from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3
Supplementary Figure 2 from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3 Open
Densitometric quantification of Western blot bands. Each graph shows the ratio between expression of protein of interest and its GAPDH loading control for Figures 2A, 2B and 2C. The image scanner Image J was used to compare the density of …
View article: Data from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3
Data from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3 Open
Phosphatase of regenerating liver-3 (PTP4A3/PRL-3) is a dual-specificity phosphatase that is upregulated in various types of cancers and is related to poor prognosis and aggressive tumor behavior. The expression level of PRL-3 is elevated …
View article: Data from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3
Data from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3 Open
Phosphatase of regenerating liver-3 (PTP4A3/PRL-3) is a dual-specificity phosphatase that is upregulated in various types of cancers and is related to poor prognosis and aggressive tumor behavior. The expression level of PRL-3 is elevated …
View article: Supplementary Figure 3 from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3
Supplementary Figure 3 from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3 Open
Densitometric quantification of Western blot bands. Each graph shows the ratio between expression of protein of interest and its GAPDH loading control for Figures 3A, 3B, 3C and 3D. The image scanner Image J was used to compare the density…
View article: Supplementary Figure 3 from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3
Supplementary Figure 3 from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3 Open
Densitometric quantification of Western blot bands. Each graph shows the ratio between expression of protein of interest and its GAPDH loading control for Figures 3A, 3B, 3C and 3D. The image scanner Image J was used to compare the density…
View article: Supplementary Figure 2 from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3
Supplementary Figure 2 from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3 Open
Densitometric quantification of Western blot bands. Each graph shows the ratio between expression of protein of interest and its GAPDH loading control for Figures 2A, 2B and 2C. The image scanner Image J was used to compare the density of …
View article: Supplementary Figure 1 from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3
Supplementary Figure 1 from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3 Open
Confirmation of transduction of INA-6 cells. PRL-3 overexpression was confirmed by A) qRT PCR and B) Immunoblotting for PRL-3. GAPDH was used as loading control. PRL-3 down regulation was confirmed by C) qRT PCR. Expression level is presen…
View article: The serine protease matriptase inhibits migration and proliferation in multiple myeloma cells
The serine protease matriptase inhibits migration and proliferation in multiple myeloma cells Open
Our findings may suggest a novel role of matriptase as a tumor suppressor in MM pathogenesis.
View article: Highly expressed genes in multiple myeloma cells – what can they tell us about the disease?
Highly expressed genes in multiple myeloma cells – what can they tell us about the disease? Open
Cancer cells can convert proto‐oncoproteins into oncoproteins by increasing the expression of genes that are oncogenic when expressed at high levels. Such genes can promote oncogenesis without being mutated. To find overexpressed genes in …
View article: Inhibition of Cytosolic Phospholipase A2α Induces Apoptosis in Multiple Myeloma Cells
Inhibition of Cytosolic Phospholipase A2α Induces Apoptosis in Multiple Myeloma Cells Open
Cytosolic phospholipase A2α (cPLA2α) is the rate-limiting enzyme in releasing arachidonic acid and biosynthesis of its derivative eicosanoids. Thus, the catalytic activity of cPLA2α plays an important role in cellular metabolism in healthy…
View article: PRL‐3 induces a positive signaling circuit between glycolysis and activation of STAT1/2
PRL‐3 induces a positive signaling circuit between glycolysis and activation of STAT1/2 Open
Multiple myeloma (MM) is an incurable hematologic malignancy resulting from the clonal expansion of plasma cells. MM cells are interacting with components of the bone marrow microenvironment such as cytokines to survive and proliferate. Ph…
View article: Bystander Memory T Cells and IMiD/Checkpoint Therapy in Multiple Myeloma: A Dangerous Tango?
Bystander Memory T Cells and IMiD/Checkpoint Therapy in Multiple Myeloma: A Dangerous Tango? Open
In this review article we discuss the role of the memory T cells in multiple myeloma (MM) and how they may influence immune responses in patients that received immunomodulating drugs and check point therapy.
View article: Phosphatase of regenerating liver‐3 regulates cancer cell metabolism in multiple myeloma
Phosphatase of regenerating liver‐3 regulates cancer cell metabolism in multiple myeloma Open
Cancer cells often depend on microenvironment signals from molecules such as cytokines for proliferation and metabolic adaptations. PRL‐3, a cytokine‐induced oncogenic phosphatase, is highly expressed in multiple myeloma cells and associat…
View article: Targeting phosphoglycerate dehydrogenase in multiple myeloma
Targeting phosphoglycerate dehydrogenase in multiple myeloma Open
Background Multiple myeloma (MM) is a hematological malignancy characterized by the clonal expansion of plasma cells in the bone marrow. To date, this disease is still incurable and novel therapeutic approaches are required. Phosphoglycera…
View article: Targeting Phosphoglycerate Dehydrogenase in Multiple Myeloma
Targeting Phosphoglycerate Dehydrogenase in Multiple Myeloma Open
Background: Multiple myeloma (MM) is a hematological malignancy characterized by the clonal expansion of plasma cells in the bone marrow. To date, this disease is still incurable and novel therapeutic approaches are required. Phosphoglycer…
View article: Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade
Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade Open
Background PD1/PDL1-directed therapies have been unsuccessful for multiple myeloma (MM), an incurable cancer of plasma cells in the bone marrow (BM). Therefore, other immune checkpoints such as extracellular adenosine and its immunosuppres…
View article: Will deeper characterization of the landscape of immune checkpoint molecules in acute myeloid leukemia bone marrow lead to improved therapeutic targeting?
Will deeper characterization of the landscape of immune checkpoint molecules in acute myeloid leukemia bone marrow lead to improved therapeutic targeting? Open
T cells in the bone marrow from patients with acute myeloid leukemia demonstrate increased expression of several immune checkpoint molecules. Can this knowledge be translated into novel therapeutic strategies?
View article: Phosphatase of regenerating liver-3 (PRL-3) is overexpressed in classical Hodgkin lymphoma and promotes survival and migration
Phosphatase of regenerating liver-3 (PRL-3) is overexpressed in classical Hodgkin lymphoma and promotes survival and migration Open
PRL-3 was overexpressed in a subset of cHL patients. Inhibition of PRL-3 increased IL-13 cytokine production and reduced migration, proliferation and viability. The effects could be mediated through regulation of the anti-apoptotic molecul…
View article: Phosphatase of regenerating liver-3 is expressed in acute lymphoblastic leukemia and mediates leukemic cell adhesion, migration and drug resistance
Phosphatase of regenerating liver-3 is expressed in acute lymphoblastic leukemia and mediates leukemic cell adhesion, migration and drug resistance Open
Phosphatase of regenerating liver-3 (PRL-3/PTP4A3) is upregulated in multiple cancers, including BCR-ABL1- and ETV6-RUNX-positive acute lymphoblastic leukemia (ALL). With this study, we aim to characterize the biological role of PRL-3 in B…
View article: Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3
Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3 Open
Phosphatase of regenerating liver-3 (PTP4A3/PRL-3) is a dual-specificity phosphatase that is upregulated in various types of cancers and is related to poor prognosis and aggressive tumor behavior. The expression level of PRL-3 is elevated …
View article: The phosphatase of regenerating liver-3 (PRL-3) is important for IL-6-mediated survival of myeloma cells
The phosphatase of regenerating liver-3 (PRL-3) is important for IL-6-mediated survival of myeloma cells Open
Multiple myeloma (MM) is a neoplastic proliferation of bone marrow plasma cells. PRL-3 is a phosphatase induced by interleukin (IL)-6 and other growth factors in MM cells and promotes MM-cell migration. PRL-3 has also been identified as a …