Éster Cerdeira Sabino
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View article: Hospitalizations due to stroke and their relationship with Chagas disease: a population-based analytical study using data from the Hospital Information System of the Brazilian National Health System, Minas Gerais, Brazil, 2022
Hospitalizations due to stroke and their relationship with Chagas disease: a population-based analytical study using data from the Hospital Information System of the Brazilian National Health System, Minas Gerais, Brazil, 2022 Open
Objective To assess whether hospitalizations due to stroke were associated with Chagas disease and the Chagas disease vulnerability index in the state of Minas Gerais. Methods This was a population-based analytical observational study. Dat…
View article: Evaluating antimicrobial prescriptions in primary health care across an entire Brazilian city through the analysis of electronic medical records: where public health and data science converge
Evaluating antimicrobial prescriptions in primary health care across an entire Brazilian city through the analysis of electronic medical records: where public health and data science converge Open
View article: Crowd signals: Early detection of disease outbreaks using real-time healthcare occupancy data
Crowd signals: Early detection of disease outbreaks using real-time healthcare occupancy data Open
Early detection of disease outbreaks is critical for effective public health response, yet traditional surveillance systems often suffer from delayed reporting. Here, we investigate whether real-time occupancy data from healthcare faciliti…
View article: Genetic diversity of Trypanosoma cruzi in individuals with chronic Chagas disease in the Northern Minas Gerais and Vale do Jequitinhonha regions, Minas Gerais, Brazil
Genetic diversity of Trypanosoma cruzi in individuals with chronic Chagas disease in the Northern Minas Gerais and Vale do Jequitinhonha regions, Minas Gerais, Brazil Open
Chagas disease, caused by the hemoflagellate parasite Trypanosoma cruzi , is a major public health problem in Latin America due to its high prevalence and significant morbidity and mortality. The T. cruzi is classified into seven distinct …
View article: EPIDEMIOLOGY OF LEG ULCERS IN SICKLE CELL DISEASE: MULTICENTER REAL-WORLD DATA STUDY IN BRAZIL
EPIDEMIOLOGY OF LEG ULCERS IN SICKLE CELL DISEASE: MULTICENTER REAL-WORLD DATA STUDY IN BRAZIL Open
View article: INFECÇÃO BACTERIANA EM DOENÇA FALCIFORME: BASES CLÍNICAS E GENÉTICAS
INFECÇÃO BACTERIANA EM DOENÇA FALCIFORME: BASES CLÍNICAS E GENÉTICAS Open
View article: STROKE IN PATIENTS WITH SICKLE CELL DISEASE: EPIDEMIOLOGICAL MEASURES FROM A MULTICENTER REAL-WORLD DATA STUDY IN BRAZIL
STROKE IN PATIENTS WITH SICKLE CELL DISEASE: EPIDEMIOLOGICAL MEASURES FROM A MULTICENTER REAL-WORLD DATA STUDY IN BRAZIL Open
View article: Dataset on Brazilian Municipal Health Policies During the COVID-19 Pandemic
Dataset on Brazilian Municipal Health Policies During the COVID-19 Pandemic Open
Brazil was severely affected by COVID-19, in terms of both the number of infections and deaths. Part of the complexity and mismanagement of health measures in Brazil stemmed from the lack of nationwide policies, leaving local governments t…
View article: Clinical, laboratory and genetic factors associated with smoking in a Brazilian Sickle Cell Disease (SCD) cohort
Clinical, laboratory and genetic factors associated with smoking in a Brazilian Sickle Cell Disease (SCD) cohort Open
Background Smoking is associated with increased morbidity among individuals with sickle cell disease (SCD). While genetic factors influencing smoking behavior have been identified in other populations, they have not been studied in individ…
View article: Active West Nile virus transmission in Brazil: an epidemiological study
Active West Nile virus transmission in Brazil: an epidemiological study Open
View article: Differential Capacitance Spectroscopy for Real-Time Monitoring of RNA Amplification
Differential Capacitance Spectroscopy for Real-Time Monitoring of RNA Amplification Open
RNA amplification is central to viral diagnostics, yet current optical and fluorometric methods, such as PCR and RT-qPCR, remain costly, complex, and resource-intensive. Here, we introduce differential capacitance spectroscopy (DCS) as a r…
View article: Genetic modifiers of frequent vaso-occlusive hospitalizations among individuals with sickle cell disease (SCD)
Genetic modifiers of frequent vaso-occlusive hospitalizations among individuals with sickle cell disease (SCD) Open
Sickle cell disease (SCD) is characterized by painful vaso-occlusive crises (VOC), which occur due to the adhesion of sickled erythrocytes and leukocytes to the endothelium, leading to vascular obstruction and tissue ischemia. Recurrent VO…
View article: Mortality from sickle cell disease in Brazil
Mortality from sickle cell disease in Brazil Open
Despite early diagnosis through neonatal screening and improved access to vaccines, antibiotics, and disease-modifying therapies, many individuals with sickle cell disease (SCD) die before age 60. This study evaluated causes and independen…
View article: Echocardiographic predictors of mortality in heart failure from Chagas cardiomyopathy: Refining risk stratification with speckle-tracking echocardiography
Echocardiographic predictors of mortality in heart failure from Chagas cardiomyopathy: Refining risk stratification with speckle-tracking echocardiography Open
View article: Evolution and spillover dynamics of yellow fever at the urban-forest interface
Evolution and spillover dynamics of yellow fever at the urban-forest interface Open
Ten years after the onset of the largest yellow fever epidemic in the Americas, its transmission dynamics in neotropical primate hosts remain unclear. Using ground- and canopy-level entomology, systematic primate carcass surveillance, and …
View article: Risk factors associated with HIV infection in four large Brazilian blood centers: A multicentric case-control study (2009–2017)
Risk factors associated with HIV infection in four large Brazilian blood centers: A multicentric case-control study (2009–2017) Open
The risk factors identified suggest that the blood donor screening process in Brazilian blood centers does not adequately identify donors at increased risk for HIV and further studies should be carried out to support changes to improve the…
View article: Plasmonic and quantitative lateral flow assay for grayscale imaging of neutralizing antibodies SARS-CoV-2
Plasmonic and quantitative lateral flow assay for grayscale imaging of neutralizing antibodies SARS-CoV-2 Open
Lateral flow immunoassays (LFIAs) have modernized decentralized mass testing and significantly impacted the healthcare system. It provides a rapid and accessible method for serological testing, which is an important tool for screening pati…
View article: COVID-19 modulates pregnancy outcomes
COVID-19 modulates pregnancy outcomes Open
The COVID-19 pandemic exposed many pregnant individuals to SARS-CoV-2. Literature suggests a link between gestational COVID-19 and adverse gestational outcomes. However, among all the factors that could impact pregnancy, COVID-19 is not th…
View article: Bridging the gap in Chagas disease management: a mixed-methods study using an implementation science approach within the Brazilian primary health care system—‘Implementa-Chagas/SaMi-Trop project’
Bridging the gap in Chagas disease management: a mixed-methods study using an implementation science approach within the Brazilian primary health care system—‘Implementa-Chagas/SaMi-Trop project’ Open
View article: Improved HIV-1 RNA detection using whole blood versus plasma in antiretroviral-treated individuals
Improved HIV-1 RNA detection using whole blood versus plasma in antiretroviral-treated individuals Open
Currently, nucleic acid testing (NAT) platforms detect HIV-1 in plasma. Using whole blood (WB) could improve HIV-1 detectability as cellular elements may also contain HIV-1 nucleic acids. We used well-characterized paired WB/plasma panels …
View article: Bimodal distributions of anti-Trypanosoma cruzi antibody levels in blood donors are associated with parasite detection and antibody waning in peripheral blood
Bimodal distributions of anti-Trypanosoma cruzi antibody levels in blood donors are associated with parasite detection and antibody waning in peripheral blood Open
Background In our previous study of blood donors in the Argentinian Chaco Province, we documented bimodal distributions of anti- Trypanosoma cruzi antibody (Ab) levels, suggesting potential self-cure in donors with low-reactive samples. Th…
View article: A VLPs based vaccine protects against Zika virus infection and prevents cerebral and testicular damage
A VLPs based vaccine protects against Zika virus infection and prevents cerebral and testicular damage Open
Still, Zika virus (ZIKV) infection poses a substantial public health risk, especially for pregnant women and their fetuses, as it can result in congenital abnormalities and fetal mortality during pregnancy. Despite significant advances in …
View article: Molecular Epidemiology of St. Louis Encephalitis Virus, São Paulo State, Brazil, 2016–2018
Molecular Epidemiology of St. Louis Encephalitis Virus, São Paulo State, Brazil, 2016–2018 Open
We detected St. Louis encephalitis virus (SLEV) in 0.16% (3/3,375) of Aedes and Sabethes spp. mosquitoes captured during 2016-2018 in São Paulo State, Brazil. We also isolated and confirmed that the SLEV strains belong to genotype III. Con…
View article: Yellow fever virus resurgence in São Paulo State, Brazil, 2024-2025
Yellow fever virus resurgence in São Paulo State, Brazil, 2024-2025 Open
Yellow fever virus (YFV) was detected in two distinct geographic locations in São Paulo State, Brazil, between September 2024 and February 2025. Phylogenetic analysis of six new genomes revealed a re-introduction in 2022 from Midwest Brazi…
View article: Sustainable Electrochemical-Magnetic Biosensor Fabricated from Recycled Materials for Label-Free Detection of SARS-CoV-2 in Human Saliva
Sustainable Electrochemical-Magnetic Biosensor Fabricated from Recycled Materials for Label-Free Detection of SARS-CoV-2 in Human Saliva Open
The COVID-19 pandemic has highlighted the critical need for scalable, rapid, and cost-effective diagnostic solutions, especially in resource-limited settings. In this study, we developed a sustainable magnetic electrochemical biosensor for…
View article: Immune and vascular modulation by HERVs: the role of CXCR1 and IL18RAP in dengue severity progression
Immune and vascular modulation by HERVs: the role of CXCR1 and IL18RAP in dengue severity progression Open
Introduction Human Endogenous Retroviruses (HERVs), which can be activated by viral infections, have complex roles in gene regulation and immune modulation. However, their contribution to disease progression is not yet fully understood. De…
View article: Transcriptomic insights into early mechanisms underlying post-chikungunya chronic inflammatory joint disease
Transcriptomic insights into early mechanisms underlying post-chikungunya chronic inflammatory joint disease Open
View article: Assessing <scp>HIV</scp> trends among blood donors in five Brazilian blood centers: The impact of individual donor assessment
Assessing <span>HIV</span> trends among blood donors in five Brazilian blood centers: The impact of individual donor assessment Open
Background In many countries, including Brazil, time‐based blood donation deferral policies for gay, bisexual, and other men who have sex with men (gbMSM) have been replaced by individual donor assessment (IDA). We examined HIV prevalence …
View article: Syphilis seroprevalence and risk factors among first-time blood donors in Brazil: A comprehensive repeated cross-sectional analysis spanning a decade
Syphilis seroprevalence and risk factors among first-time blood donors in Brazil: A comprehensive repeated cross-sectional analysis spanning a decade Open
Background Syphilis remains a global health challenge, with rising incidence rates worldwide Prevalence surveys conducted in Brazil over extended periods of time are scarce. This study examines the secular trends and risk factors for syphi…
View article: Dynamics of SARS-CoV-2 infection over two epidemic waves in Manaus, Brazil: A serological study of seven thousand blood donors
Dynamics of SARS-CoV-2 infection over two epidemic waves in Manaus, Brazil: A serological study of seven thousand blood donors Open
Background Most longitudinal studies of COVID-19 incidence have used unlinked samples. The city of Manaus, Brazil, has a blood donation program which allows sample linkage, and was struck by two large COVID-19 epidemic waves between mid-20…