Ester Feldmesser
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View article: Mapping the transcriptional landscape of algal resistance to viral infection reveals a core expression program
Mapping the transcriptional landscape of algal resistance to viral infection reveals a core expression program Open
Summary Algal blooms and their demise by viruses drive global‐scale ecological processes in the ocean. These blooms form the foundation of marine food webs, regulate microbial communities, and shape biogeochemical cycles. Although algal po…
View article: Mapping the transcriptional landscape of algal resistance to viral infection reveals a core expression program
Mapping the transcriptional landscape of algal resistance to viral infection reveals a core expression program Open
Algal blooms and their demise by viruses drive global-scale ecological processes in the ocean. These blooms form the foundation of marine food webs, regulate microbial communities, and shape biogeochemical cycles. Although algal population…
View article: Acanthamoeba polyphaga de novo transcriptome and its dynamics during Mimivirus infection
Acanthamoeba polyphaga de novo transcriptome and its dynamics during Mimivirus infection Open
Mimivirus bradfordmassiliense (Mimivirus) is a giant virus that infects Acanthamoeba species – opportunistic human pathogens. Long- and short-read sequencing were used to generate a de novo transcriptome of the host and followed the dynami…
View article: Cathepsin X is a conserved cell death protein involved in algal response to environmental stress
Cathepsin X is a conserved cell death protein involved in algal response to environmental stress Open
Phytoplankton play a crucial role in global primary production and can form vast blooms in aquatic ecosystems. Bloom demise and the rapid turnover of phytoplankton are suggested to involve programmed cell death (PCD) induced by diverse env…
View article: Kinesin family member 2A gates nociception
Kinesin family member 2A gates nociception Open
Nociceptive axons undergo remodeling as they innervate their targets during development and in response to environmental insults and pathological conditions. How is nociceptive morphogenesis regulated? Here, we show that the microtubule de…
View article: The Role of Vitamin D in<i>Emiliania huxleyi</i>: A Microalgal Perspective on UV Exposure
The Role of Vitamin D in<i>Emiliania huxleyi</i>: A Microalgal Perspective on UV Exposure Open
An essential interaction between sunlight and eukaryotes involves the production of vitamin D through exposure to ultraviolet (UV) radiation. While extensively studied in vertebrates, the role of vitamin D in non-animal eukaryotes like mic…
View article: Supplemental data for the publication: "The Role of Vitamin D in Emiliania huxleyi: A Microalgal Perspective on UV-B Exposure"
Supplemental data for the publication: "The Role of Vitamin D in Emiliania huxleyi: A Microalgal Perspective on UV-B Exposure" Open
The following table contains raw transcriptomic data of Emiliania huxleyi CCMP3266 grown under continuous UV radiation or control conditions for 7, 10, and 13 days, obtained using the MARS-seq protocol (Keren-Shaul H. et al. 2013) Column A…
View article: Supplemental data for the publication: "The Role of Vitamin D in Emiliania huxleyi: A Microalgal Perspective on UV-B Exposure"
Supplemental data for the publication: "The Role of Vitamin D in Emiliania huxleyi: A Microalgal Perspective on UV-B Exposure" Open
The following table contains raw transcriptomic data of Emiliania huxleyi CCMP3266 grown under continuous UV radiation or control conditions for 7, 10, and 13 days, obtained using the MARS-seq protocol (Keren-Shaul H. et al. 2013) Column A…
View article: Supplemental data for the publication: "The Role of Vitamin D in Emiliania huxleyi: A Microalgal Perspective on UV-B Exposure"
Supplemental data for the publication: "The Role of Vitamin D in Emiliania huxleyi: A Microalgal Perspective on UV-B Exposure" Open
The following table contains raw transcriptomic data of Emiliania huxleyi CCMP3266 grown under continuous UV radiation or control conditions for 7, 10, and 13 days, obtained using the MARS-seq protocol (Keren-Shaul H. et al. 2013) Column A…
View article: Supplemental data for the publication: "The Role of Vitamin D in Emiliania huxleyi: A Microalgal Perspective on UV-B Exposure"
Supplemental data for the publication: "The Role of Vitamin D in Emiliania huxleyi: A Microalgal Perspective on UV-B Exposure" Open
The following table contains raw transcriptomic data of Emiliania huxleyi CCMP3266 grown under continuous UV radiation or control conditions for 7, 10, and 13 days, obtained using the MARS-seq protocol (Keren-Shaul H. et al. 2013) Column A…
View article: Dendritic cell ICAM-1 strengthens synapses with CD8 T cells but is not required for their early differentiation
Dendritic cell ICAM-1 strengthens synapses with CD8 T cells but is not required for their early differentiation Open
Lymphocyte priming in lymph nodes (LNs) was postulated to depend on the formation of stable T cell receptor (TCR)-specific immune synapses (ISs) with antigen (Ag)-presenting dendritic cells (DCs). The high-affinity LFA-1 ligand ICAM-1 was …
View article: VSV-ΔG-Spike Candidate Vaccine Induces Protective Immunity and Protects K18-hACE2 Mice against SARS-CoV-2 Variants
VSV-ΔG-Spike Candidate Vaccine Induces Protective Immunity and Protects K18-hACE2 Mice against SARS-CoV-2 Variants Open
Since the emergence of the original SARS-CoV-2, several variants were described, raising questions as to the ability of recently developed vaccine platforms to induce immunity and provide protection against these variants. Here, we utilize…
View article: <scp>miR</scp>‐4734 conditionally suppresses <scp>ER</scp> stress‐associated proinflammatory responses
<span>miR</span>‐4734 conditionally suppresses <span>ER</span> stress‐associated proinflammatory responses Open
Prolonged metabolic stress can lead to severe pathologies. In metabolically challenged primary fibroblasts, we assigned a novel role for the poorly characterized miR‐4734 in restricting ATF4 and IRE1‐mediated upregulation of a set of proin…
View article: Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients
Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients Open
The TP53 gene is mutated in approximately 60% of all colorectal cancer (CRC) cases. Over 20% of all TP53-mutated CRC tumors carry missense mutations at position R175 or R273. Here we report that CRC tumors harboring R273 mutations are more…
View article: Complete Genome Sequence of <i>Emiliania huxleyi</i> Virus Strain M1, Isolated from an Induced <i>E. huxleyi</i> Bloom in Bergen, Norway
Complete Genome Sequence of <i>Emiliania huxleyi</i> Virus Strain M1, Isolated from an Induced <i>E. huxleyi</i> Bloom in Bergen, Norway Open
Emiliania huxleyi virus strain M1 (EhVM1), a large double-stranded DNA virus from the family Phycodnaviridae , was isolated from an Emiliania huxleyi bloom during a mesocosm experiment in Raunefjorden, Bergen, Norway. Here, we report its c…
View article: Supplementary material
Supplementary material Open
This repository contains supplementary data of the manuscript "Acanthamoeba polyphaga de novo transcriptome and its dynamics during Mimivirus infection"
View article: Dendritic cell ICAM-1 strengthens immune synapses but is dispensable for effector and memory responses
Dendritic cell ICAM-1 strengthens immune synapses but is dispensable for effector and memory responses Open
Lymphocyte priming in lymph nodes (LNs) depends on the formation of functional TCR specific immune synapses (ISs) with antigen (Ag) presenting dendritic cells. The high affinity LFA-1 ligand ICAM-1 has been implicated in different ISs stud…
View article: Combined presentation and immunogenicity analysis reveals a recurrent RAS.Q61K neoantigen in melanoma
Combined presentation and immunogenicity analysis reveals a recurrent RAS.Q61K neoantigen in melanoma Open
Neoantigens are now recognized drivers of the antitumor immune response. Recurrent neoantigens, shared among groups of patients, have thus become increasingly coveted therapeutic targets. Here, we report on the data-driven identification o…
View article: Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients
Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients Open
Colorectal cancer (CRC) is the third most common cancer worldwide. The TP53 gene is mutated in approximately 60% of all CRC cases. Sporadic CRC is characterized by high prevalence of TP53 hotspot missense mutations. In particular, over 20 …
View article: Ecological significance of extracellular vesicles in modulating host-virus interactions during algal blooms
Ecological significance of extracellular vesicles in modulating host-virus interactions during algal blooms Open
Extracellular vesicles are produced by organisms from all kingdoms and serve a myriad of functions, many of which involve cell-cell signaling, especially during stress conditions and host-pathogen interactions. In the marine environment, c…
View article: Reduced Lamin A/C Does Not Facilitate Cancer Cell Transendothelial Migration but Compromises Lung Metastasis
Reduced Lamin A/C Does Not Facilitate Cancer Cell Transendothelial Migration but Compromises Lung Metastasis Open
The mechanisms by which the nuclear lamina of tumor cells influences tumor growth and migration are highly disputed. Lamin A and its variant lamin C are key lamina proteins that control nucleus stiffness and chromatin conformation. Downreg…
View article: The ecological significance of extracellular vesicles in modulating host-virus interactions during algal blooms
The ecological significance of extracellular vesicles in modulating host-virus interactions during algal blooms Open
Extracellular vesicles are produced by organisms from all kingdoms and serve a myriad of functions, many of which involve cell-cell signaling, especially during stress conditions and host-pathogen interactions. In the marine environment, c…
View article: Emiliania huxleyi pan-transcriptome: mRNA, protein, and annotation
Emiliania huxleyi pan-transcriptome: mRNA, protein, and annotation Open
This project contains the files of the Emiliania huxleyi pan-transcriptome. It was constructed from Illumina reads of the following strains: CCMP2090, CCMP373, CCMP374.Included are the following files:unified_loci_Ehux_v4_May2020.fasta - o…
View article: The molecular mechanisms that determine different degrees of polyphagy in the <i>Bemisia tabaci</i> species complex
The molecular mechanisms that determine different degrees of polyphagy in the <i>Bemisia tabaci</i> species complex Open
The whitefly Bemisia tabaci is a closely related group of >35 cryptic species that feed on the phloem sap of a broad range of host plants. Species in the complex differ in their host‐range breadth, but the mechanisms involved remain poorly…