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View article: The Medical Burden of Drug‐Resistant Epilepsy in an Outpatient Clinic of a Tertiary Hospital: A Prospective Study Based on Real‐World Evidence
The Medical Burden of Drug‐Resistant Epilepsy in an Outpatient Clinic of a Tertiary Hospital: A Prospective Study Based on Real‐World Evidence Open
Objective Drug‐resistant epilepsy (DRE) leads to a range of medical and social consequences, which contribute to a high disease burden. We aimed to describe factors associated with an increased medical burden in DRE. Methods We designed a …
View article: Persistent headache after aneurysmal subarachnoid hemorrhage: Prevalence, characteristics, and migraine history as a prognostic factor
Persistent headache after aneurysmal subarachnoid hemorrhage: Prevalence, characteristics, and migraine history as a prognostic factor Open
Objectives/Background Persistent headache (PH) after an aneurysmal subarachnoid hemorrhage (aSAH) and the influence of migraine history (MH) on its evolution and prognosis is poorly understood. Our study aims are to (1) determine the preva…
View article: Association of the Timing and Type of Acute Symptomatic Seizures With Poststroke Epilepsy and Mortality
Association of the Timing and Type of Acute Symptomatic Seizures With Poststroke Epilepsy and Mortality Open
BACKGROUND: Acute symptomatic seizures (ASyS) increase the risk of epilepsy and mortality after a stroke. The impact of the timing and type of ASyS remains unclear. METHODS: This multicenter cohort study included data from 9 centers betwee…
View article: Association of the timing and type of acute symptomatic seizures with post-stroke epilepsy and mortality
Association of the timing and type of acute symptomatic seizures with post-stroke epilepsy and mortality Open
Background Acute symptomatic seizures (ASyS) increase the risk of epilepsy and mortality after a stroke. The impact of the timing and type of ASyS remains unclear. Methods This multicenter cohort study included data from nine centers betwe…
View article: 20467. IMPACTO DE LA EPILEPSIA FARMACORRESISTENTE EN LAS CONSULTAS EXTERNAS DE UN HOSPITAL TERCIARIO: UN ESTUDIO PROSPECTIVO BASADO EN LA PRÁCTICA CLÍNICA
20467. IMPACTO DE LA EPILEPSIA FARMACORRESISTENTE EN LAS CONSULTAS EXTERNAS DE UN HOSPITAL TERCIARIO: UN ESTUDIO PROSPECTIVO BASADO EN LA PRÁCTICA CLÍNICA Open
View article: 21638. CRISIS EPILÉPTICAS EN PACIENTES CON ENFERMEDAD DE ALZHEIMER: CARACTERIZACIÓN EN UNA SERIE DE CASOS Y RELACIÓN CON LA EDAD DE INICIO DE LA ENFERMEDAD
21638. CRISIS EPILÉPTICAS EN PACIENTES CON ENFERMEDAD DE ALZHEIMER: CARACTERIZACIÓN EN UNA SERIE DE CASOS Y RELACIÓN CON LA EDAD DE INICIO DE LA ENFERMEDAD Open
View article: Implications for driving based on the risk of seizures after ischaemic stroke
Implications for driving based on the risk of seizures after ischaemic stroke Open
Background In addition to other stroke-related deficits, the risk of seizures may impact driving ability after stroke. Methods We analysed data from a multicentre international cohort, including 4452 adults with acute ischaemic stroke and …
View article: Identifying risk for status epilepticus with the ADAN scale: a prospective multicenter validation study
Identifying risk for status epilepticus with the ADAN scale: a prospective multicenter validation study Open
Objetivo. El estado epiléptico (EE) es una enfermedad grave con elevada mortalidad. Este estudio tiene como objetivo validar la escala ADAN, propuesta recientemente para identificar pacientes con alto riesgo de desarrollar un EE. Método. S…
View article: Exploratory study of blood biomarkers in patients with post-stroke epilepsy
Exploratory study of blood biomarkers in patients with post-stroke epilepsy Open
Introduction: In addition to clinical factors, blood-based biomarkers can provide useful information on the risk of developing post-stroke epilepsy (PSE). Our aim was to identify serum biomarkers at stroke onset that could contribute to pr…
View article: Riesgo de epilepsia tras una primera crisis epiléptica de etiología desconocida en pacientes de edad avanzada
Riesgo de epilepsia tras una primera crisis epiléptica de etiología desconocida en pacientes de edad avanzada Open
The risk of epilepsy in the long term following a single seizure of unknown etiology in elderly patients is greater than 80%. Arterial hypertension and mild cognitive impairment at baseline are the most common clinical features. Cortical a…
View article: Efficacy of Perampanel in Nocturnal Seizures in Adult Patients with Epilepsy
Efficacy of Perampanel in Nocturnal Seizures in Adult Patients with Epilepsy Open
Objective . Nocturnal seizures are usually underestimated and represent a major problem in adult patients with epilepsy. Our aim was to study the effectiveness of perampanel for the treatment of nocturnal seizures in adult patients with ep…
View article: Real-Life Effectiveness and Tolerability of Brivaracetam in Focal to Bilateral and Primary Generalized Tonic-Clonic Seizures
Real-Life Effectiveness and Tolerability of Brivaracetam in Focal to Bilateral and Primary Generalized Tonic-Clonic Seizures Open
Purpose. Brivaracetam (BRV), an antiseizure medication indicated for focal-onset seizures, has shown efficacy in the treatment of focal to bilateral tonic-clonic seizures (FBTCS). We aimed to determine the effectiveness and safety of BRV i…
View article: Implications of starting antiepileptic treatment prior to electroencephalography in first epileptic seizures
Implications of starting antiepileptic treatment prior to electroencephalography in first epileptic seizures Open
Administration of AEDs before an early EEG following a first seizure does not decrease the likelihood of detecting epileptiform abnormalities. These findings suggest that starting AED treatment immediately in patients with a high risk of e…
View article: Association of Mortality and Risk of Epilepsy With Type of Acute Symptomatic Seizure After Ischemic Stroke and an Updated Prognostic Model
Association of Mortality and Risk of Epilepsy With Type of Acute Symptomatic Seizure After Ischemic Stroke and an Updated Prognostic Model Open
Importance Acute symptomatic seizures occurring within 7 days after ischemic stroke may be associated with an increased mortality and risk of epilepsy. It is unknown whether the type of acute symptomatic seizure influences this risk. Objec…
View article: Perampanel outcomes at different stages of treatment in people with focal and generalized epilepsy treated in clinical practice: Evidence from the PERMIT study
Perampanel outcomes at different stages of treatment in people with focal and generalized epilepsy treated in clinical practice: Evidence from the PERMIT study Open
Introduction The PERMIT study is the largest pooled analysis of perampanel (PER) clinical practice data conducted to date. Methods This post-hoc analysis of PERMIT investigated the effectiveness, safety and tolerability of PER when used as…
View article: Association of Time of Day With Outcomes Among Patients Triaged for a Suspected Severe Stroke in Nonurban Catalonia
Association of Time of Day With Outcomes Among Patients Triaged for a Suspected Severe Stroke in Nonurban Catalonia Open
Background: We aim to assess whether time of day modified the treatment effect in the RACECAT trial (Direct Transfer to an Endovascular Center Compared to Transfer to the Closest Stroke Center in Acute Stroke Patients With Suspected Large …
View article: Workflows and Outcomes in Patients With Suspected Large Vessel Occlusion Stroke Triaged in Urban and Nonurban Areas
Workflows and Outcomes in Patients With Suspected Large Vessel Occlusion Stroke Triaged in Urban and Nonurban Areas Open
Background: We aim to compare the outcome of patients from urban areas, where the referral center is able to perform thrombectomy, with patients from nonurban areas enrolled in the RACECAT trial (Direct Transfer to an Endovascular Center C…
View article: Relationship between visuoperceptual functions and parietal structural abnormalities in temporal lobe epilepsy
Relationship between visuoperceptual functions and parietal structural abnormalities in temporal lobe epilepsy Open
Purpose: Progressive gray matter volume reductions beyond the epileptogenic area has been described in temporal lobe epilepsy. There is less evidence regarding correlations between gray and white matter volume changes and multi-domain cogn…
View article: Onset of efficacy and adverse events during Cenobamate titration period
Onset of efficacy and adverse events during Cenobamate titration period Open
Reductions in seizure frequency occurred during titration with initial efficacy observed prior to reaching the target dose. These reductions were regarded as clinically meaningful because they may indicate early efficacy at lower doses tha…
View article: Epileptic seizures in the emergency room: clinical and electroencephalographic findings associated with brain perfusion patterns on computed tomography
Epileptic seizures in the emergency room: clinical and electroencephalographic findings associated with brain perfusion patterns on computed tomography Open
View article: Estado epiléptico refractario en un varón de 76 años con antecedentes de trasplante renal
Estado epiléptico refractario en un varón de 76 años con antecedentes de trasplante renal Open
View article: Seizures after Ischemic Stroke: A Matched Multicenter Study
Seizures after Ischemic Stroke: A Matched Multicenter Study Open
Objective The purpose of this study was to identify risk factors for acute symptomatic seizures and post‐stroke epilepsy after acute ischemic stroke and evaluate the effects of reperfusion treatment. Methods We assessed the risk factors fo…
View article: PERMIT study: a global pooled analysis study of the effectiveness and tolerability of perampanel in routine clinical practice
PERMIT study: a global pooled analysis study of the effectiveness and tolerability of perampanel in routine clinical practice Open
View article: Magnetic resonance imaging findings in focal‐onset status epilepticus
Magnetic resonance imaging findings in focal‐onset status epilepticus Open
Background and purpose Magnetic resonance imaging (MRI) is commonly used in the diagnostic work‐up for status epilepticus (SE). The purpose of this study was to characterize MRI features in SE patients and determine their association with …
View article: Medium‐term effects of COVID‐19 pandemic on epilepsy: A follow‐up study
Medium‐term effects of COVID‐19 pandemic on epilepsy: A follow‐up study Open
Depression rates increased significantly after the first wave. Depression, drug-resistant epilepsy, and a reduction in family income were independent risk factors for an increased seizure frequency. Perception of telemedicine worsened, ind…
View article: Implicaciones de iniciar fármacos antiepilépticos previo a la realización de EEG en primeras crisis epilépticas
Implicaciones de iniciar fármacos antiepilépticos previo a la realización de EEG en primeras crisis epilépticas Open
Administration of AEDs before an early EEG following a first seizure does not decrease the likelihood of detecting epileptiform abnormalities. These findings suggest that starting AED treatment immediately in patients with a high risk of e…
View article: Blood Biomarkers to Predict Long-Term Mortality after Ischemic Stroke
Blood Biomarkers to Predict Long-Term Mortality after Ischemic Stroke Open
Stroke is a major cause of disability and death globally, and prediction of mortality represents a crucial challenge. We aimed to identify blood biomarkers measured during acute ischemic stroke that could predict long-term mortality. Nine …
View article: Overnight switch from levetiracetam to brivaracetam. Safety and tolerability
Overnight switch from levetiracetam to brivaracetam. Safety and tolerability Open
View article: Efficacy and tolerability of perampanel as a first add-on therapy with different anti-seizure drugs
Efficacy and tolerability of perampanel as a first add-on therapy with different anti-seizure drugs Open
View article: Epilepsy in time of COVID‐19: A survey‐based study
Epilepsy in time of COVID‐19: A survey‐based study Open
The COVID-19 pandemic has effects in epilepsy patients. Patients with tumor-related, drug-resistant epilepsy, insomnia, and economic difficulties are at a higher risk of increased seizure frequency. Telemedicine represents a suitable tool …