Esther Mintzer
YOU?
Author Swipe
View article: Simulating a <i>for-loop</i> in the human genome: Design and evaluation of recombinase genetic programs that count to three
Simulating a <i>for-loop</i> in the human genome: Design and evaluation of recombinase genetic programs that count to three Open
Summary Pluripotent cells specialize into numerous cell types by receiving external signals, making fate decisions, and executing differentiation functions – a paradigm similar to computer algorithms. While advances in biosensor design hav…
View article: Human skin rejuvenation via mRNA
Human skin rejuvenation via mRNA Open
Aging is characterized by a gradual decline in function, partly due to accumulated molecular damage. Human skin undergoes both chronological aging and environmental degradation, particularly UV-induced photoaging. Detrimental structural an…
View article: Engineering elephant models of cold-adaptation and cancer resistance
Engineering elephant models of cold-adaptation and cancer resistance Open
Throughout their evolution, proboscideans have gotten larger and spread to occupy novel environments throughout the world. These phenotypic changes have been accompanied by a suite of genetic changes including those responsible for tumor s…
View article: Comparative transcriptome analysis of acne vulgaris, rosacea, and hidradenitis suppurativa supports high‐dose dietary zinc as a therapeutic agent
Comparative transcriptome analysis of acne vulgaris, rosacea, and hidradenitis suppurativa supports high‐dose dietary zinc as a therapeutic agent Open
Acne vulgaris, rosacea, and hidradenitis suppurativa are enduring inflammatory skin conditions that frequently manifest with akin clinical attributes, posing a considerable challenge for their distinctive diagnosis. While these conditions …
View article: Comparative Transcriptome Analysis of Acne vulgaris, Rosacea, and Hidradenitis Suppurativa Supports High Dose Dietary Zinc as a Therapeutic Agent
Comparative Transcriptome Analysis of Acne vulgaris, Rosacea, and Hidradenitis Suppurativa Supports High Dose Dietary Zinc as a Therapeutic Agent Open
Acne vulgaris, rosacea, and hidradenitis suppurativa are enduring inflammatory skin conditions that frequently manifest with akin clinical attributes, posing a considerable challenge for their distinctive diagnosis. While these conditions …
View article: Gene editing without<i>ex vivo</i>culture evades genotoxicity in human hematopoietic stem cells
Gene editing without<i>ex vivo</i>culture evades genotoxicity in human hematopoietic stem cells Open
SUMMARY Gene editing the BCL11A erythroid enhancer is a validated approach to fetal hemoglobin (HbF) induction for β-hemoglobinopathy therapy, though heterogeneity in edit allele distribution and HbF response may impact its safety and effi…
View article: Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors
Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors Open
While genome editing has been revolutionized by the advent of CRISPR-based nucleases, difficulties in achieving efficient, nuclease-mediated, homology-directed repair (HDR) still limit many applications. Commonly used DNA donors such as pl…
View article: Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice
Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice Open
Prime editors (PEs) mediate genome modification without utilizing double-stranded DNA breaks or exogenous donor DNA as a template. PEs facilitate nucleotide substitutions or local insertions or deletions within the genome based on the temp…
View article: Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice
Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice Open
Prime editors (PEs) mediate genome modification without utilizing double-stranded DNA breaks or exogenous donor DNA as a template. PEs facilitate nucleotide substitutions or local insertions or deletions within the genome based on the temp…
View article: Precision Cas9 Genome Editing<i>in vivo</i>with All-in-one, Self-targeting AAV Vectors
Precision Cas9 Genome Editing<i>in vivo</i>with All-in-one, Self-targeting AAV Vectors Open
Adeno-associated virus (AAV) vectors are important delivery platforms for therapeutic genome editing but are severely constrained by cargo limits, especially for large effectors like Cas9s. Simultaneous delivery of multiple vectors can lim…
View article: Efficient Homology-directed Repair with Circular ssDNA Donors
Efficient Homology-directed Repair with Circular ssDNA Donors Open
While genome editing has been revolutionized by the advent of CRISPR-based nucleases, difficulties in achieving efficient, nuclease-mediated, homology-directed repair (HDR) still limit many applications. Commonly used DNA donors such as pl…
View article: Enhanced Cas12a editing in mammalian cells and zebrafish
Enhanced Cas12a editing in mammalian cells and zebrafish Open
Type V CRISPR-Cas12a systems provide an alternate nuclease platform to Cas9, with potential advantages for specific genome editing applications. Here we describe improvements to the Cas12a system that facilitate efficient targeted mutagene…