Okechukwu Paul-Chima Ugwu
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View article: Updates on cancer vaccines in brain cancer: Advances in neuroblastoma, delivery systems, and emerging technologies.
Updates on cancer vaccines in brain cancer: Advances in neuroblastoma, delivery systems, and emerging technologies. Open
Neuroblastoma stands as a major concern in pediatric oncology because it develops from neural crest cells as a neuroendocrine cancer. Nanoparticle-based vaccine delivery approaches the therapeutic activity of immune cells only toward tumor…
View article: A narrative review of power allocation strategies and successive interference cancellation enhancement in NOMA based 5G and future wireless networks
A narrative review of power allocation strategies and successive interference cancellation enhancement in NOMA based 5G and future wireless networks Open
Non-Orthogonal Multiple Access (NOMA), which has been known to achieve outstanding spectral efficiency and massive connectivity, has been identified as an intriguing multiple-access solution for 5G and beyond wireless networks. Power alloc…
View article: Implementing artificial intelligence and machine learning algorithms for optimized crop management: a systematic review on data-driven approach to enhancing resource use and agricultural sustainability
Implementing artificial intelligence and machine learning algorithms for optimized crop management: a systematic review on data-driven approach to enhancing resource use and agricultural sustainability Open
Artificial intelligence (AI) and machine learning (ML) are transforming agriculture by enabling data-driven decisions that elevate productivity and sustainability. This review synthesises 95 studies published between 2013 and 2023 that eva…
View article: A comprehensive review of AI-native 6G: integrating semantic communications, reconfigurable intelligent surfaces, and edge intelligence for next-generation connectivity
A comprehensive review of AI-native 6G: integrating semantic communications, reconfigurable intelligent surfaces, and edge intelligence for next-generation connectivity Open
This review explores the evolving vision of sixth-generation (6G) networks as a paradigm shift from conventional data-centric communication to intelligence-native architectures, where meaning, context, and adaptive decision-making are cent…
View article: Hybrid biofactories: integrating microalgae and engineered microbiomes for enhanced biofuel production in circular carbon systems
Hybrid biofactories: integrating microalgae and engineered microbiomes for enhanced biofuel production in circular carbon systems Open
With the growing world demand for sustainable and carbon-neutral energy sources, microalgae have surfaced as a promising source of next-generation biofuels based on their high lipid content, fast growth rate, and their ability to grow on w…
View article: Securing the future: AI-driven cybersecurity in the age of autonomous IoT
Securing the future: AI-driven cybersecurity in the age of autonomous IoT Open
The Autonomous Internet of Things (A-IoT) represents a major advancement in interconnected systems, enabling self-governing smart devices to operate collaboratively across domains such as smart cities, industrial automation, healthcare, an…
View article: Targeting Cellular Senescence for Healthy Aging: Advances in Senolytics and Senomorphics
Targeting Cellular Senescence for Healthy Aging: Advances in Senolytics and Senomorphics Open
Targeting cellular senescence offers a promising avenue for promoting healthy aging and mitigating age-linked diseases. Continued research into senescence-modulating interventions may lead to novel therapeutics designed to prolong healthsp…
View article: Epitranscriptomic alterations induced by environmental toxins: implications for RNA modifications and disease
Epitranscriptomic alterations induced by environmental toxins: implications for RNA modifications and disease Open
View article: Metabolomics-Driven Standardization of Herbal Medicine: Advances, Applications, and Sustainability Considerations
Metabolomics-Driven Standardization of Herbal Medicine: Advances, Applications, and Sustainability Considerations Open
Standardizing traditional herbal formulations poses significant challenges due to inherent variability in plant sources, environmental conditions, and processing methods. This narrative review explores how metabolomics a powerful high-thro…
View article: Combined Hyaluronic Acid Nanobioconjugates Impair CD44-Signaling for Effective Treatment Against Obesity: A Review of Comparison with Other Actors
Combined Hyaluronic Acid Nanobioconjugates Impair CD44-Signaling for Effective Treatment Against Obesity: A Review of Comparison with Other Actors Open
CD44, a key hyaluronic acid (HA) receptor, has emerged as a central mediator of adipose tissue inflammation, remodeling, and insulin resistance in obesity. Its overexpression in obese adipose depots promotes leukocyte infiltration, pro-inf…
View article: Unveiling the therapeutic potential of the gut microbiota–brain axis: Novel insights and clinical applications in neurological disorders
Unveiling the therapeutic potential of the gut microbiota–brain axis: Novel insights and clinical applications in neurological disorders Open
Over the last several years, the gut microbiota–brain axis has been the focus of medical study, demonstrating the bidirectional nature of gut and brain communication and the resulting influence on neurological and mental health. Trillions …
View article: Bridging the gap: telemedicine as a solution for HIV care inequities in rural and vulnerable communities
Bridging the gap: telemedicine as a solution for HIV care inequities in rural and vulnerable communities Open
View article: Endogenous Plant signals and human Health: Molecular mechanisms, ecological functions, and therapeutic Prospects
Endogenous Plant signals and human Health: Molecular mechanisms, ecological functions, and therapeutic Prospects Open
View article: Biotechnological innovations in soil health management: a systematic review of integrating microbiome engineering, bioinformatics, and sustainable practices
Biotechnological innovations in soil health management: a systematic review of integrating microbiome engineering, bioinformatics, and sustainable practices Open
Fertile soil nourishes plant, animal, and human life. However, soil exploitation is responsible for the majority of inefficient agricultural practices, forest loss, global warming, and surface erosion. Technology is required to repair soil…
View article: Mitigation of Malaria in Sub-Saharan Africa through Vaccination: A Budding Road Map for Global Malaria Eradication
Mitigation of Malaria in Sub-Saharan Africa through Vaccination: A Budding Road Map for Global Malaria Eradication Open
BACKGROUND: Malaria remains a major public health and economic burden globally, with sub-Saharan Africa (SSA) accounting for over 90% of cases and deaths. Children under five and pregnant women are the most vulnerable. Resistance to artemi…
View article: The Role of Phytochemicals in Age-Related Cognitive Decline: A Natural Solution for Brain Health
The Role of Phytochemicals in Age-Related Cognitive Decline: A Natural Solution for Brain Health Open
Age-related cognitive decline, characterized by memory loss, attention deficits, and reduced executive function, remains a major public health challenge, with limited pharmaceutical interventions offering symptomatic relief. Phytochemicals…
View article: Economic burden of malaria on developing countries: A mini review
Economic burden of malaria on developing countries: A mini review Open
View article: Harnessing nature: plant-derived nanocarriers for targeted drug delivery in cancer therapy
Harnessing nature: plant-derived nanocarriers for targeted drug delivery in cancer therapy Open
Background/objective: The rising global burden of cancer underscores the need for innovative therapies that address limitations of conventional treatments, such as drug resistance, systemic toxicity, and poor bioavailability. Plant-derived…
View article: Lipid-based nano-carriers for the delivery of anti-obesity natural compounds: advances in targeted delivery and precision therapeutics
Lipid-based nano-carriers for the delivery of anti-obesity natural compounds: advances in targeted delivery and precision therapeutics Open
Obesity is a major global health challenge, contributing to metabolic disorders such as type 2 diabetes, cardiovascular diseases, and hypertension. The increasing prevalence of obesity, driven by sedentary lifestyles, poor dietary habits, …
View article: The price of progress: Assessing the financial costs of HIV/AIDS management in East Africa
The price of progress: Assessing the financial costs of HIV/AIDS management in East Africa Open
The epidemic of HIV/AIDS, also known as human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), continues to be a major global public health concern with significant economic ramifications. East Africa is one of the sev…
View article: Medical preparedness for bioterrorism and chemical warfare: A public health integration review
Medical preparedness for bioterrorism and chemical warfare: A public health integration review Open
Global public health faces a major danger from chemical and biological weapon-related terrorism which requires comprehensive emergency preparedness and response strategies. This review investigates present-day public health measures agains…
View article: Unveiling the microbial orchestra: exploring the role of microbiota in cancer development and treatment
Unveiling the microbial orchestra: exploring the role of microbiota in cancer development and treatment Open
View article: Exploring the use of phytotherapy in benign prostatic hyperplasia [BPH]: a systematic review
Exploring the use of phytotherapy in benign prostatic hyperplasia [BPH]: a systematic review Open
Background Benign prostatic hyperplasia [BPH] is a prevalent condition among aging men, characterized by prostate gland enlargement leading to lower urinary tract symptoms [LUTS]. Conventional treatments like alpha-blockers and 5-alpha-re…
View article: Harnessing plant metabolic pathways for innovative diabetes management: unlocking the therapeutic potential of medicinal plants
Harnessing plant metabolic pathways for innovative diabetes management: unlocking the therapeutic potential of medicinal plants Open
The exploration of plant signaling pathways is transforming the way diabetes is managed, providing new, multi-target strategies for controlling this complex metabolic disorder. Medicinal plants are rich in bioactive compounds like phytohor…
View article: Artificial intelligence in personalized medicine: transforming diagnosis and treatment
Artificial intelligence in personalized medicine: transforming diagnosis and treatment Open
The concept of personalised medicine, which adapts care to each patient based on their specific characteristics, has been a long-sought dream in the health field. Artificial intelligence (AI) has made this dream a reality with the advent o…
View article: Natural Antidiabetic Agents: Current Evidence and Development Pathways from Medicinal Plants to Clinical use
Natural Antidiabetic Agents: Current Evidence and Development Pathways from Medicinal Plants to Clinical use Open
Diabetes mellitus is a long-term metabolic condition marked by chronically high levels of glucose in the blood due to insufficient synthesis of insulin or impaired insulin function. Throughout history, several civilizations have used tradi…
View article: Sustainable development goals (SDGs) and resilient healthcare systems: Addressing medicine and public health challenges in conflict zones
Sustainable development goals (SDGs) and resilient healthcare systems: Addressing medicine and public health challenges in conflict zones Open
This review explores the integration of sustainable development goals (SDGs) into healthcare organizations in conflict zones, with a specific focus on emergent models aimed at improving population health. The primary objective is to examin…
View article: The role of pharmacological interventions in managing urological complications during pregnancy and childbirth: A review
The role of pharmacological interventions in managing urological complications during pregnancy and childbirth: A review Open
Pregnancy leads to a number of structural and functional changes in the urinary system, which makes females susceptible to urological complications. This review aims to discuss the epidemiology, complications and prevention and management …
View article: Exploring the Potential of Medicinal Plants in Bone Marrow Regeneration and Hematopoietic Stem Cell Therapy
Exploring the Potential of Medicinal Plants in Bone Marrow Regeneration and Hematopoietic Stem Cell Therapy Open
Blood cell production through hematopoiesis within the bone marrow serves both to maintain blood equilibrium and to respond to tissue injury and infectious demands. Hematopoietic stem cell (HSC) therapy developments have revolutionized med…
View article: Optimizing emergency response systems in urban health crises: A project management approach to public health preparedness and response
Optimizing emergency response systems in urban health crises: A project management approach to public health preparedness and response Open
Effective management of health crises requires public health preparedness and response, especially in urban settings where the complexity and scope of catastrophes provide considerable challenges. The integration of project management fram…