Eswar Prasad R. Iyer
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View article: The Zinc-BED Transcription Factor Bedwarfed Promotes Proportional Dendritic Growth and Branching through Transcriptional and Translational Regulation in Drosophila
The Zinc-BED Transcription Factor Bedwarfed Promotes Proportional Dendritic Growth and Branching through Transcriptional and Translational Regulation in Drosophila Open
Dendrites are the primary points of sensory or synaptic input to a neuron and play an essential role in synaptic integration and neural function. Despite the functional importance of dendrites, relatively less is known about the underlying…
View article: The Zinc-BED transcription factor Bedwarfed promotes proportional dendritic growth and branching through transcriptional and translational regulation in<i>Drosophila</i>
The Zinc-BED transcription factor Bedwarfed promotes proportional dendritic growth and branching through transcriptional and translational regulation in<i>Drosophila</i> Open
Dendrites are the primary points of sensory or synaptic inputs to a neuron and play an essential role in synaptic integration and neural function. Despite the functional importance of dendrites, relatively less is known about the underlyin…
View article: Sexually dimorphic neural encoding of threat discrimination in nucleus accumbens afferents drives suppression of reward behavior
Sexually dimorphic neural encoding of threat discrimination in nucleus accumbens afferents drives suppression of reward behavior Open
Learning to predict threat is essential but equally important yet often overlooked is learning about the absence of threat. Interrogating neural activity in two nucleus accumbens afferents in male and female mice during aversive and neutra…
View article: Barcoded oligonucleotides ligated on RNA amplified for multiplexed and parallel <i>in situ</i> analyses
Barcoded oligonucleotides ligated on RNA amplified for multiplexed and parallel <i>in situ</i> analyses Open
We present barcoded oligonucleotides ligated on RNA amplified for multiplexed and parallel insitu analyses (BOLORAMIS), a reverse transcription-free method for spatially-resolved, targeted, in situ RNA identification of single or multiple …
View article: Expansion sequencing: Spatially precise in situ transcriptomics in intact biological systems
Expansion sequencing: Spatially precise in situ transcriptomics in intact biological systems Open
Identifying transcript location in cells Identifying where specific RNAs occur within a cell or tissue has been limited by technology and imaging capabilities. Expansion microscopy has allowed for better visualization of small structures b…
View article: Expansion Sequencing: Spatially Precise<i>In Situ</i>Transcriptomics in Intact Biological Systems
Expansion Sequencing: Spatially Precise<i>In Situ</i>Transcriptomics in Intact Biological Systems Open
Methods for highly multiplexed RNA imaging are limited in spatial resolution, and thus in their ability to localize transcripts to nanoscale and subcellular compartments. We adapt expansion microscopy, which physically expands biological s…
View article: The ethics of experimenting with human brain tissue
The ethics of experimenting with human brain tissue Open
View article: Barcoded oligonucleotides ligated on RNA amplified for multiplex and parallel in-situ analyses
Barcoded oligonucleotides ligated on RNA amplified for multiplex and parallel in-situ analyses Open
We present B arcoded O ligonucleotides L igated O n R NA A mplified for M ultiplexed and parallel I n- S itu analysis (BOLORAMIS), a reverse-transcription (RT)-free method for spatially-resolved, targeted, in-situ RNA identification of sin…
View article: Dendritic Cytoskeletal Architecture Is Modulated by Combinatorial Transcriptional Regulation in <i>Drosophila melanogaster</i>
Dendritic Cytoskeletal Architecture Is Modulated by Combinatorial Transcriptional Regulation in <i>Drosophila melanogaster</i> Open
Transcription factors (TFs) have emerged as essential cell autonomous mediators of subtype specific dendritogenesis; however, the downstream effectors of these TFs remain largely unknown, as are the cellular events that TFs control to dire…
View article: Correction: Addressing the ethical issues raised by synthetic human entities with embryo-like features
Correction: Addressing the ethical issues raised by synthetic human entities with embryo-like features Open
View article: Addressing the ethical issues raised by synthetic human entities with embryo-like features
Addressing the ethical issues raised by synthetic human entities with embryo-like features Open
The "14-day rule" for embryo research stipulates that experiments with intact human embryos must not allow them to develop beyond 14 days or the appearance of the primitive streak. However, recent experiments showing that suitably cultured…
View article: Author response: Addressing the ethical issues raised by synthetic human entities with embryo-like features
Author response: Addressing the ethical issues raised by synthetic human entities with embryo-like features Open
View article: The TRP Channels Pkd2, NompC, and Trpm Act in Cold-Sensing Neurons to Mediate Unique Aversive Behaviors to Noxious Cold in Drosophila
The TRP Channels Pkd2, NompC, and Trpm Act in Cold-Sensing Neurons to Mediate Unique Aversive Behaviors to Noxious Cold in Drosophila Open
View article: Highly efficient Cas9-mediated transcriptional programming
Highly efficient Cas9-mediated transcriptional programming Open