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View article: Clinical Utility of a Digital Dermoscopy Image-Based Artificial Intelligence Device in the Diagnosis and Management of Skin Cancer by Dermatologists
Clinical Utility of a Digital Dermoscopy Image-Based Artificial Intelligence Device in the Diagnosis and Management of Skin Cancer by Dermatologists Open
Background: Patients with skin lesions suspicious for skin cancer or atypical melanocytic nevi of uncertain malignant potential often present to dermatologists, who may have variable dermoscopy triage clinical experience. Objective: To eva…
View article: Appropriate Statistical Methods to Assess Cross-study Diagnostic 23-Gene Expression Profile Test Performance for Cutaneous Melanocytic Neoplasms
Appropriate Statistical Methods to Assess Cross-study Diagnostic 23-Gene Expression Profile Test Performance for Cutaneous Melanocytic Neoplasms Open
Comparing studies of molecular ancillary diagnostic tests for difficult-to-diagnose cutaneous melanocytic neoplasms presents a methodological challenge, given the disparate ways accuracy metrics are calculated. A recent report by Boothby-S…
View article: Diagnostic Utility of the 23-gene Expression Profile Test for an Atypical Intradermal Melanocytic Proliferation
Diagnostic Utility of the 23-gene Expression Profile Test for an Atypical Intradermal Melanocytic Proliferation Open
Ancillary tests such as immunohistochemistry (IHC) and gene expression profile (GEP) testing may be needed to arrive at a definitive diagnosis for some atypical melanocytic neoplasms. A 34-year-old male with a family history of melanoma pr…
View article: A Physician's Guide to the Use of Gene Expression Profile Ancillary Diagnostic Testing for Cutaneous Melanocytic Neoplasms.
A Physician's Guide to the Use of Gene Expression Profile Ancillary Diagnostic Testing for Cutaneous Melanocytic Neoplasms. Open
Open communication between dermatopathologists and dermatologists, especially regarding GEP testing, can be a vital component to achieve appropriate clinicopathologic correlation for otherwise ambiguous melanocytic lesions.
View article: Superficial solitary fibrous tumor masquerading as a dermoid cyst: a case report
Superficial solitary fibrous tumor masquerading as a dermoid cyst: a case report Open
BACKGROUND: Solitary fibrous tumors (SFTs) are relatively rare spindle cell neoplasms uncommonly seen in dermatology practice. Initially discovered as a pleural tumor, SFTs have also been found in extra-pleural sites including the skin and…
View article: Primary cutaneous perivascular epithelioid cell tumors: two cases and a review of the literature
Primary cutaneous perivascular epithelioid cell tumors: two cases and a review of the literature Open
Report _Case Presentation _Photo Vignette _Letter Authors declare that the contents of this article are their own original unpublished findings. Title: Primary cutaneous perivascular epithelioid cell tumors: two cases and a review of the l…
View article: Case of Metastatic Malignant Melanoma Simulating Granuloma Annulare
Case of Metastatic Malignant Melanoma Simulating Granuloma Annulare Open
Malignant melanoma and particularly metastatic melanoma represent a diagnostic challenge due to the wide variety of histologic patterns, resemblance to benign entities, and extensive range of clinical presentations. A high index of suspici…
View article: Dysmorphic Trichophyton rubrum Mimicking Blastomycosis
Dysmorphic Trichophyton rubrum Mimicking Blastomycosis Open
We will describe a 62 year old immunocompromised, diabetic, male patient who presented with several cutaneous lesions. The patient was 4 years post-nephrectomy due to renal cell carcinoma and 6 months post-renal transplantation at time of …
View article: 61-Year-Old White Female with a Non-Healing Ulcerated Ankle Mass
61-Year-Old White Female with a Non-Healing Ulcerated Ankle Mass Open
Merkel cell carcinoma is a rare cutaneous carcinoma from the tactile Merkel cells. With fewer than half the patients surviving more than one year and fewer than 20% surviving beyond five years. These tumors are rarely suspected until the b…
View article: Establishing an evidence-based decision point for clinical use of the 31-gene expression profile test in cutaneous melanoma
Establishing an evidence-based decision point for clinical use of the 31-gene expression profile test in cutaneous melanoma Open
Treatment plans for cutaneous melanoma are based upon individual risk of recurrence. Decisions made post-diagnosis include recommendation for a sentinel lymph node biopsy (SLNB), followed by management decisions such as surveillance, frequ…
View article: Aleukemic leukemia cutis February 2019
Aleukemic leukemia cutis February 2019 Open
Readers comment on aleukemic leukemia cutis (February 2019) and on human papillomavirus vaccination (March 2019).
View article: Review of Instructive Cases from the Zola Cooper and Lee T. Nesbitt Seminar
Review of Instructive Cases from the Zola Cooper and Lee T. Nesbitt Seminar Open
Histopathological examination is considered to be the gold standard for diagnosis. However, research has shown that clinical correlation with pathological examination is crucial for the appropriate diagnosis. This is especially true in der…
View article: How to Succeed in Fellowship Acquisition: A Survey of Pathology Residents
How to Succeed in Fellowship Acquisition: A Survey of Pathology Residents Open
Medical school curricula limit students' exposure to pathology practice while pathology subspecialty training programs require residents to apply for fellowships as early as the end of their first year of training. Thus, limited exposure t…
View article: Duodenal-Type Follicular Lymphoma: A Clinicopathologic Review
Duodenal-Type Follicular Lymphoma: A Clinicopathologic Review Open
Duodenal-type follicular lymphoma (D-FL) is a newly recognized entity in the 2016 World Health Organization classification update. It has an immunophenotype similar to that of other FLs and usually carries the typical t(14;18)(q32;q21) tra…
View article: Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Used to Correctly Identify Kingella kingae Endocarditis
Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Used to Correctly Identify Kingella kingae Endocarditis Open
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect proteins in micro-organisms.Comparison of the protein fingerprint with a database of reference spectra allows MALDI-TOF MS to…