Ethan Baratz
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View article: The iron chaperone and nucleic acid–binding activities of poly(rC)-binding protein 1 are separable and independently essential
The iron chaperone and nucleic acid–binding activities of poly(rC)-binding protein 1 are separable and independently essential Open
Significance Poly(rC)-binding protein 1 (PCBP1) regulates multiple cellular processes; many studies have focused on its role in tumor formation and metastasis through its capacity to bind nucleic acids. PCBP1 binds to DNA and RNA and media…
View article: Iron Chaperone Poly rC Binding Protein 1 Protects Mouse Liver From Lipid Peroxidation and Steatosis
Iron Chaperone Poly rC Binding Protein 1 Protects Mouse Liver From Lipid Peroxidation and Steatosis Open
Background and Aims Iron is essential yet also highly chemically reactive and potentially toxic. The mechanisms that allow cells to use iron safely are not clear; defects in iron management are a causative factor in the cell‐death pathway …
View article: The human-specific <i>BOLA2</i> duplication modifies iron homeostasis and anemia predisposition in chromosome 16p11.2 autism patients
The human-specific <i>BOLA2</i> duplication modifies iron homeostasis and anemia predisposition in chromosome 16p11.2 autism patients Open
Human-specific duplications at chromosome 16p11.2 mediate recurrent pathogenic 600 kbp BP4-BP5 copy number variations, one of the most common genetic causes of autism. These copy number polymorphic duplications are under positive selection…
View article: PHRM-04. COMPARISON OF PHARMACOKINETIC PARAMETERS BETWEEN NON-HUMAN PRIMATES AND HUMAN PATIENTS
PHRM-04. COMPARISON OF PHARMACOKINETIC PARAMETERS BETWEEN NON-HUMAN PRIMATES AND HUMAN PATIENTS Open
INTRODUCTION: Chemotherapeutic agents are evaluated in at least two animal species prior to evaluation in humans. In children with CNS tumors, the plasma and CSF pharmacokinetics of these agents are derived from models like non-human prima…