Ethan Levien
YOU?
Author Swipe
View article: Slow trajectories generate divergent cell fates following antibiotic stress
Slow trajectories generate divergent cell fates following antibiotic stress Open
Single-cell microfluidic experiments have shown that upon abrupt exposures to antibiotics, genetically homogeneous microbial populations undergo divergent cell fates. The mechanism underlying this divergence is not clear and in particular,…
View article: Size-structured populations with growth fluctuations: Feynman--Kac formula and decoupling
Size-structured populations with growth fluctuations: Feynman--Kac formula and decoupling Open
We study a size--structured population model of proliferating cells in which biomass accumulation and binary division occur at rates modulated by fluctuating internal phenotypes. We quantify how fluctuations in internal variables that infl…
View article: Extremal events dictate population growth rate inference
Extremal events dictate population growth rate inference Open
Recent methods have been developed to map single-cell lineage statistics to population growth. Because population growth selects for exponentially rare phenotypes, these methods inherently depend on sampling large deviations from finite da…
View article: Coalescent processes emerging from large deviations
Coalescent processes emerging from large deviations Open
The classical model for the genealogies of a neutrally evolving population in a fixed environment is due to Kingman. Kingman’s coalescent process, which produces a binary tree, emerges universally from many microscopic models in which the …
View article: Coalescent processes emerging from large deviations
Coalescent processes emerging from large deviations Open
The classical model for the genealogies of a neutrally evolving population in a fixed environment is due to Kingman. Kingman's coalescent process, which produces a binary tree, universally emerges from many microscopic models in which the …
View article: Time-resolved microfluidics unravels individual cellular fates during double-strand break repair
Time-resolved microfluidics unravels individual cellular fates during double-strand break repair Open
Background Double-strand break repair (DSBR) is a highly regulated process involving dozens of proteins acting in a defined order to repair a DNA lesion that is fatal for any living cell. Model organisms such as Saccharomyces cerevisiae ha…
View article: Evolutionary dynamics in non-Markovian models of microbial populations
Evolutionary dynamics in non-Markovian models of microbial populations Open
In the past decade, great strides have been made to quantify the dynamics of single-cell growth and division in microbes. In order to make sense of the evolutionary history of these organisms, we must understand how features of single-cell…
View article: Cooperative assembly confers regulatory specificity and long-term genetic circuit stability
Cooperative assembly confers regulatory specificity and long-term genetic circuit stability Open
In eukaryotes, links in gene regulatory networks are often maintained through cooperative self-assembly between transcriptional regulators (TRs) and DNA cis-regulatory motifs, a strategy widely thought to enable highly specific regulatory …
View article: Single-cell microfluidic analysis unravels individual cellular fates during Double-Strand Break Repair
Single-cell microfluidic analysis unravels individual cellular fates during Double-Strand Break Repair Open
Trinucleotide repeat expansions are responsible for two dozen human disorders. Contracting expanded repeats by Double-Strand Break Repair (DSBR) might be a therapeutic approach. Given the complexity of manipulating human cells, recent assa…
View article: Erratum: Large Deviation Principle Linking Lineage Statistics to Fitness in Microbial Populations [Phys. Rev. Lett. <b>125</b>, 048102 (2020)]
Erratum: Large Deviation Principle Linking Lineage Statistics to Fitness in Microbial Populations [Phys. Rev. Lett. <b>125</b>, 048102 (2020)] Open
This corrects the article DOI: 10.1103/PhysRevLett.125.048102.
View article: Non-genetic variability: survival strategy or nuisance?
Non-genetic variability: survival strategy or nuisance? Open
The observation that phenotypic variability is ubiquitous in isogenic populations has led to a multitude of experimental and theoretical studies seeking to probe the causes and consequences of this variability. Whether it be in the context…
View article: Large Deviation Principle Linking Lineage Statistics to Fitness in Microbial Populations
Large Deviation Principle Linking Lineage Statistics to Fitness in Microbial Populations Open
In exponentially proliferating populations of microbes, the population doubles at a rate less than the average doubling time of a single-cell due to variability at the single-cell level. It is known that the distribution of generation time…
View article: The interplay of phenotypic variability and fitness in finite microbial populations
The interplay of phenotypic variability and fitness in finite microbial populations Open
In isogenic microbial populations, phenotypic variability is generated by a combination of stochastic mechanisms, such as gene expression, and deterministic factors, such as asymmetric segregation of cell volume. Here we address the questi…
View article: Quantifying phenotypic variability and fitness in finite microbial populations
Quantifying phenotypic variability and fitness in finite microbial populations Open
Summary In isogenic microbial populations, phenotypic variability is generated by a combination of intrinsic factors, specified by cell physiology, and environmental factors. Here we address the question: how does phenotypic variability of…
View article: Coupling sample paths to the partial thermodynamic limit in stochastic chemical reaction networks
Coupling sample paths to the partial thermodynamic limit in stochastic chemical reaction networks Open
Many biochemical systems appearing in applications have a multiscale structure so that they converge to piecewise deterministic Markov processes in a thermodynamic limit. The statistics of the piecewise deterministic process can be obtaine…