Ethan Srinivasan
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View article: IMMU-81. Glioblastoma and other intracranial pathologies elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses
IMMU-81. Glioblastoma and other intracranial pathologies elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses Open
Immunotherapies remain largely ineffective against intracranial malignancies such as glioblastoma (GBM), in part due to profound systemic and local immune dysfunction. Hallmarks of systemic immune dysfunction include bone marrow T cell seq…
View article: CTLT-03 STEROID RESPONSIVENESS PREDICTS FUNCTIONAL OUTCOME FOLLOWING LITT IN MOTOR CORTEX METASTASES
CTLT-03 STEROID RESPONSIVENESS PREDICTS FUNCTIONAL OUTCOME FOLLOWING LITT IN MOTOR CORTEX METASTASES Open
INTRODUCTION Metastases associated with the primary motor cortex (PMC) are associated with significant debility. Laser interstitial thermal therapy (LITT) could proffer less invasive treatment if the risk of thermal damage to corticospinal…
View article: DISP-01. FACTORS AFFECTING POST-ABLATION OUTCOMES AND TRIAL ENROLLMENT IN DIVERSE PATIENTS UNDERGOING LASER INTERSTITIAL THERMAL THERAPY
DISP-01. FACTORS AFFECTING POST-ABLATION OUTCOMES AND TRIAL ENROLLMENT IN DIVERSE PATIENTS UNDERGOING LASER INTERSTITIAL THERMAL THERAPY Open
BACKGROUND Laser interstitial thermal therapy (LITT) is a surgical treatment for progressive brain metastases (BM) following stereotactic radiosurgery (SRS). Although LITT has been increasingly accepted, little is known regarding factors i…
View article: SURG-07. QUANTIFYING THE RISK OF SHORT TERM SEIZURES FOLLOWING LASER INTERSTITIAL THERMAL THERAPY
SURG-07. QUANTIFYING THE RISK OF SHORT TERM SEIZURES FOLLOWING LASER INTERSTITIAL THERMAL THERAPY Open
BACKGROUND Tumor-related epilepsy is a common sequela of both primary and metastatic brain tumors, as well as radiation necrosis (RN). Laser interstitial thermal therapy (LITT) is an effective option for lesional cytoreduction but induces …
View article: NIMG-05. ARTIFICIAL INTELLIGENCE-BASED RESPONSE ASSESSMENT FOR PATIENTS RECEIVING LASER INTERSTITIAL THERMAL THERAPY
NIMG-05. ARTIFICIAL INTELLIGENCE-BASED RESPONSE ASSESSMENT FOR PATIENTS RECEIVING LASER INTERSTITIAL THERMAL THERAPY Open
BACKGROUND Laser interstitial thermal therapy (LITT) is a minimally invasive option for tissue diagnosis, cytoreduction, and rapid post-operative return to systemic therapies for patients with brain tumors or radiation necrosis. As ablated…
View article: SURG-06. IMPACT OF LASER INTERSTITIAL THERMAL THERAPY VERSUS RESECTION FOR METASTASES ASSOCIATED WITH THE MOTOR CORTEX
SURG-06. IMPACT OF LASER INTERSTITIAL THERMAL THERAPY VERSUS RESECTION FOR METASTASES ASSOCIATED WITH THE MOTOR CORTEX Open
BACKGROUND For brain metastases (BM), resection remains a mainstay for the upfront management of large, symptomatic lesions, while laser interstitial thermal therapy (LITT) has become a key treatment for radiographically progressive BM fol…
View article: SRGD-03 PRESENTATION AND POST-OPERATIVE OUTCOMES IN DIVERSE PATIENTS RECEIVING LASER ABLATION FOR CENTRAL NERVOUS SYSTEM METASTASES
SRGD-03 PRESENTATION AND POST-OPERATIVE OUTCOMES IN DIVERSE PATIENTS RECEIVING LASER ABLATION FOR CENTRAL NERVOUS SYSTEM METASTASES Open
OBJECTIVE Laser interstitial thermal therapy (LITT) is a minimally invasive option for the management of intracranial pathologies, including radiographically progressive tumors following stereotactic radiosurgery. Although LITT has been in…
View article: IMUN-04 COMBINING CHECKPOINT BLOCKADE AND LASER ABLATION FOR PROGRESSIVE NON-SMALL CELL LUNG CANCER BRAIN METASTASES
IMUN-04 COMBINING CHECKPOINT BLOCKADE AND LASER ABLATION FOR PROGRESSIVE NON-SMALL CELL LUNG CANCER BRAIN METASTASES Open
BACKGROUND Laser interstitial thermal therapy (LITT) is a minimally invasive surgical treatment being employed frequently for radiographically progressive brain metastases (BM). Considerable interest exists in combining LITT-mediated in si…
View article: NIRL-01 DEEP LEARNING-BASED VOLUMETRIC SEGMENTATION ENABLES RESPONSE ASSESSMENT AFTER LASER INTERSTITIAL THERMAL THERAPY
NIRL-01 DEEP LEARNING-BASED VOLUMETRIC SEGMENTATION ENABLES RESPONSE ASSESSMENT AFTER LASER INTERSTITIAL THERMAL THERAPY Open
BACKGROUND Laser interstitial thermal therapy (LITT) allows for definitive tissue diagnosis, surgical cytoreduction, and faster post-operative return to systemic therapies for patients with brain tumors or radiation necrosis. Ablated tissu…
View article: SRGD-04 FUNCTIONAL OUTCOMES FOLLOWING LASER ABLATION VERSUS RESECTION OF MOTOR CORTEX METASTASES
SRGD-04 FUNCTIONAL OUTCOMES FOLLOWING LASER ABLATION VERSUS RESECTION OF MOTOR CORTEX METASTASES Open
BACKGROUND Laser interstitial thermal therapy (LITT) has clinical utility in treating radiographically progressive brain metastases (BM) following stereotactic radiosurgery (SRS), while resection has been reserved for large, symptomatic le…
View article: Automated segmentation of ablated lesions using deep convolutional neural networks: A basis for response assessment following laser interstitial thermal therapy
Automated segmentation of ablated lesions using deep convolutional neural networks: A basis for response assessment following laser interstitial thermal therapy Open
Background Laser interstitial thermal therapy (LITT) of intracranial tumors or radiation necrosis enables tissue diagnosis, cytoreduction, and rapid return to systemic therapies. Ablated tissue remains in situ, resulting in characteristic …
View article: Combination checkpoint blockade and laser interstitial thermal therapy in radiographically progressive non-small cell lung cancer brain metastases
Combination checkpoint blockade and laser interstitial thermal therapy in radiographically progressive non-small cell lung cancer brain metastases Open
Background Laser interstitial thermal therapy (LITT) is a minimally invasive surgical treatment being employed frequently for radiographically progressive brain metastases. Considerable interest exists in combining LITT-mediated in situ va…
View article: Glioblastoma and other intracranial tumors elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses
Glioblastoma and other intracranial tumors elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses Open
Intracranial tumors present unique challenges for immunotherapy. These can include both local and systemic modes of immune suppression whose mechanistic underpinnings are incompletely understood. Here, we reveal that tumors harbored intrac…
View article: IMMU-49. BETA-ADRENERGIC BLOCKADE LICENSES THE USE OF IMMUNOTHERAPY IN PRIMARY AND METASTATIC BRAIN TUMORS
IMMU-49. BETA-ADRENERGIC BLOCKADE LICENSES THE USE OF IMMUNOTHERAPY IN PRIMARY AND METASTATIC BRAIN TUMORS Open
Immunotherapy is less effective against intracranial metastases compared to extracranial metastases and ineffective against primary brain tumors such as glioblastoma. Brain tumors present a unique challenge to in the context of immunothera…
View article: SURG-38. SAFETY AND EFFICACY OF COMBINATORIAL IMMUNE CHECKPOINT BLOCKADE AND LASER INTERSTITIAL THERMAL THERAPY
SURG-38. SAFETY AND EFFICACY OF COMBINATORIAL IMMUNE CHECKPOINT BLOCKADE AND LASER INTERSTITIAL THERMAL THERAPY Open
INTRODUCTION Treatment of intracranial lesions with laser interstitial thermal therapy (LITT) allows for simultaneous cytoreduction and the potential to generate an anti-tumor immune response. The safety and efficacy of combination immune …
View article: EXTH-30. GOLD NANOSTARS OBVIATE LIMITATIONS TO LASER INTERSTITIAL THERMAL THERAPY (LITT) AND ENHANCE THE POST-LITT IMMUNE RESPONSE
EXTH-30. GOLD NANOSTARS OBVIATE LIMITATIONS TO LASER INTERSTITIAL THERMAL THERAPY (LITT) AND ENHANCE THE POST-LITT IMMUNE RESPONSE Open
Laser interstitial thermal therapy (LITT) is a minimally-invasive technique for the treatment of intracranial tumors that uses a stereotactically-guided laser and real-time magnetic resonance imaging (MRI) to monitor ablation progress. Pre…
View article: EXTH-15. A NOVEL IMMUNE-BASED TREATMENT STRATEGY FOR COMBATTING PROTEIN TUMOR HETEROGENEITY
EXTH-15. A NOVEL IMMUNE-BASED TREATMENT STRATEGY FOR COMBATTING PROTEIN TUMOR HETEROGENEITY Open
Cell-based immunotherapy has revolutionized the treatment of many hematological malignancies but has mostly fail against solid tumors, including glioblastoma (GBM). The reason for this failure is multi-fold, but one of the most significant…
View article: 891 Beta-adrenergic blockade licenses the use of immunotherapy in primary and metastatic brain tumors
891 Beta-adrenergic blockade licenses the use of immunotherapy in primary and metastatic brain tumors Open
Background Immunotherapy is less effective against intracranial metastases compared to extracranial metastases and ineffective against primary brain tumors such as glioblastoma. Brain tumors present a unique challenge to in the context of …
View article: SYST-17 GOLD NANOSTARS ENHANCE THE EFFICACY AND SAFETY OF LASER INTERSTITIAL THERAPY FOR THE TREATMENT OF INTRACRANIAL TUMORS
SYST-17 GOLD NANOSTARS ENHANCE THE EFFICACY AND SAFETY OF LASER INTERSTITIAL THERAPY FOR THE TREATMENT OF INTRACRANIAL TUMORS Open
Laser interstitial thermal therapy (LITT) is a minimally-invasive technique for the treatment of intracranial tumors that uses a stereotactically-guided laser for ablation. Magnetic resonance thermal imaging is used to monitor ablation pro…
View article: Gold Nanostars Obviate Limitations to Laser Interstitial Thermal Therapy (LITT) for the Treatment of Intracranial Tumors
Gold Nanostars Obviate Limitations to Laser Interstitial Thermal Therapy (LITT) for the Treatment of Intracranial Tumors Open
Purpose: Laser interstitial thermal therapy (LITT) is an effective minimally invasive treatment option for intracranial tumors. Our group produced plasmonics-active gold nanostars (GNS) designed to preferentially accumulate within intracra…
View article: Laser ablation of a sphenoid wing meningioma: A case report and review of the literature
Laser ablation of a sphenoid wing meningioma: A case report and review of the literature Open
Background: Meningiomas are the most common primary central nervous system neoplasm in the United States. While the majority of meningiomas are benign, the World Health Organization (WHO) Grade I tumors, a not-insignificant proportion of t…
View article: Erratum to “E.C. Lerner, E.S. Srinivasan, G. Broadwater, et al. Factors Associated With New-Onset Seizures Following Stereotactic Radiosurgery for Newly Diagnosed Brain Metastases. Adv Radiat Oncol. 2022;7:101054.”
Erratum to “E.C. Lerner, E.S. Srinivasan, G. Broadwater, et al. Factors Associated With New-Onset Seizures Following Stereotactic Radiosurgery for Newly Diagnosed Brain Metastases. Adv Radiat Oncol. 2022;7:101054.” Open
[This corrects the article DOI: 10.1016/j.adro.2022.101054.].
View article: Risk of Tract Seeding Following Laser Interstitial Thermal Therapy for Brain Tumors
Risk of Tract Seeding Following Laser Interstitial Thermal Therapy for Brain Tumors Open
BACKGROUND: The management of intracranial oncological disease remains a significant challenge despite advances in systemic cancer therapy. Laser interstitial thermal therapy (LITT) represents a novel treatment for local control of brain t…
View article: Commentary: Laser Interstitial Thermal Therapy for First-Line Treatment of Surgically Accessible Recurrent Glioblastoma: Outcomes Compared With a Surgical Cohort
Commentary: Laser Interstitial Thermal Therapy for First-Line Treatment of Surgically Accessible Recurrent Glioblastoma: Outcomes Compared With a Surgical Cohort Open
LITT is an increasingly used minimally invasive surgery in neuro-oncology. Current literature has demonstrated its safety and efficacy in treating primary brain tumors, brain metastases, and radiation necrosis, particularly in the context …
View article: Factors Associated With New-Onset Seizures Following Stereotactic Radiosurgery for Newly Diagnosed Brain Metastases
Factors Associated With New-Onset Seizures Following Stereotactic Radiosurgery for Newly Diagnosed Brain Metastases Open
Our data suggest that larger total treatment volume and the presence of focal neurologic deficits at presentation are associated with new-onset seizures within 3 months of SRS. High-risk patients undergoing SRS may benefit from counseling …
View article: LOCL-09 SHORT-TERM SEIZURE OUTCOMES IN PATIENTS WITH TREATED WITH LASER INTERSTITIAL THERMAL THERAPY
LOCL-09 SHORT-TERM SEIZURE OUTCOMES IN PATIENTS WITH TREATED WITH LASER INTERSTITIAL THERMAL THERAPY Open
Laser interstitial thermal therapy (LITT) is a minimally invasive treatment modality for intracranial tumor and radiation necrosis (RN). A transient increase in edema following LITT typically resolves within three months post-procedure. We…
View article: LOCL-14 FACTORS ASSOCIATED WITH TRACT SEEDING AFTER LASER INTERSTITIAL THERMAL THERAPY FOR INTRACRANIAL TUMORS
LOCL-14 FACTORS ASSOCIATED WITH TRACT SEEDING AFTER LASER INTERSTITIAL THERMAL THERAPY FOR INTRACRANIAL TUMORS Open
Laser interstitial thermal therapy (LITT) is a growing minimally-invasive approach for treatment of intracranial tumors. Stereotactic placement of the laser catheter within the target lesion carries a theoretical risk of tract seeding, whi…