Étienne Croteau
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View article: CT-scan assessment of lung volumes and effect of gravity on lung ventilation during and after total liquid ventilation in piglets
CT-scan assessment of lung volumes and effect of gravity on lung ventilation during and after total liquid ventilation in piglets Open
Total liquid ventilation (TLV) offers hope for helping nano-preterm infants adapt to the extrauterine environment at birth. We aimed to test whether lung volumes could be maintained over time during TLV and whether the prone position alter…
View article: Heart ketone metabolism under acute ketone supplementation in ZDF rats, a type 2 diabetes heart failure model
Heart ketone metabolism under acute ketone supplementation in ZDF rats, a type 2 diabetes heart failure model Open
View article: Shivering, but not adipose tissue thermogenesis, increases as a function of mean skin temperature in cold-exposed men and women
Shivering, but not adipose tissue thermogenesis, increases as a function of mean skin temperature in cold-exposed men and women Open
SUMMARY Skin cooling results in the activation of heat generating mechanisms to counteract heat lost to the environment. Here, we aim to understand the extent that variations in cold-stimulated heat production may be driven by differences …
View article: Ct-Scan Assessment of Lung Volumes and Effect of Gravity on Lung Ventilation During and after Total Liquid Ventilation in Piglets
Ct-Scan Assessment of Lung Volumes and Effect of Gravity on Lung Ventilation During and after Total Liquid Ventilation in Piglets Open
View article: Cerebral and myocardial kinetics of [11C]acetoacetate and [11C]β-hydroxybutyrate: A comparative crossover study in healthy rats
Cerebral and myocardial kinetics of [11C]acetoacetate and [11C]β-hydroxybutyrate: A comparative crossover study in healthy rats Open
View article: Cardiorenal ketone metabolism in healthy humans assessed by 11C-acetoacetate PET: effect of D-β-hydroxybutyrate, a meal, and age
Cardiorenal ketone metabolism in healthy humans assessed by 11C-acetoacetate PET: effect of D-β-hydroxybutyrate, a meal, and age Open
The heart and kidney have a high energy requirement, but relatively little is known about their utilization of ketones as a potential energy source. We assessed the metabolism of the ketone tracer, carbon-11 acetoacetate ( 11 C-AcAc), by t…
View article: The effects of the β<sub>1</sub>‐adrenergic receptor antagonist bisoprolol administration on mirabegron‐stimulated human brown adipose tissue thermogenesis
The effects of the β<sub>1</sub>‐adrenergic receptor antagonist bisoprolol administration on mirabegron‐stimulated human brown adipose tissue thermogenesis Open
Aim Pharmacological stimulation of human brown adipose tissue (BAT) has been hindered by ineffective activation or undesirable off‐target effects. Oral administration of the maximal allowable dose of mirabegron (200 mg), a β 3 ‐adrenergic …
View article: A ketogenic diet lowers myocardial fatty acid oxidation but does not affect oxygen consumption: a study in overweight humans
A ketogenic diet lowers myocardial fatty acid oxidation but does not affect oxygen consumption: a study in overweight humans Open
Objective A ketogenic diet (KD) characterized by very low carbohydrate intake and high fat consumption may simultaneously induce weight loss and be cardioprotective. The “thrifty substrate hypothesis” posits that ketone bodies are more ene…
View article: Synthesis and Preclinical Evaluation of 22-[<sup>18</sup>F]Fluorodocosahexaenoic Acid as a Positron Emission Tomography Probe for Monitoring Brain Docosahexaenoic Acid Uptake Kinetics
Synthesis and Preclinical Evaluation of 22-[<sup>18</sup>F]Fluorodocosahexaenoic Acid as a Positron Emission Tomography Probe for Monitoring Brain Docosahexaenoic Acid Uptake Kinetics Open
Docosahexaenoic acid [22:6(n-3), DHA], a polyunsaturated fatty acid, has an important role in regulating neuronal functions and in normal brain development. Dysregulated brain DHA uptake and metabolism are found in individuals carry…
View article: Manipulation of Dietary DHA does not Alter DHA Brain Uptake Kinetics in Mice Despite Changing Brain and Plasma DHA Levelsvs
Manipulation of Dietary DHA does not Alter DHA Brain Uptake Kinetics in Mice Despite Changing Brain and Plasma DHA Levelsvs Open
Background Increased brain docosahexaenoic acid (DHA) uptake reflects a compensatory mechanism for maintaining brain DHA homeostasis and can be captured through PET‐MRI scan uptake studies using radiolabeled DHA. It has been previously sho…
View article: Cardiorenal ketone metabolism: a positron emission tomography study in healthy humans
Cardiorenal ketone metabolism: a positron emission tomography study in healthy humans Open
Ketones are alternative energy substrates for the heart and kidney but no studies have investigated their metabolism simultaneously in both organs in humans. The present double tracer positron emission tomography (PET) study evaluated the …
View article: OR31-03 Testosterone Gender-affirming Hormonal Therapy Is Associated With Decreased Cerebral Blood Flow In Transgender Teens
OR31-03 Testosterone Gender-affirming Hormonal Therapy Is Associated With Decreased Cerebral Blood Flow In Transgender Teens Open
Disclosure: S. Cote: None. K. Fathy: None. S. Lenet: None. O. Espinosa-Bentancourt: None. E. Lavallee: None. E. Croteau: None. D. Rottembourg: None. J. Lepage: None. K. Whittingstall: None. There is increasing demand for gender-affirming h…
View article: Inhibition of the beta-1 adrenergic receptor does not potentiate mirabegron-stimulated human brown adipose tissue thermogenesis.
Inhibition of the beta-1 adrenergic receptor does not potentiate mirabegron-stimulated human brown adipose tissue thermogenesis. Open
Pharmacological stimulation of human brown adipose tissue (BAT) has been hindered by either ineffective activation or undesirable off-target secondary effects. Oral administration of the maximal allowable dose of mirabegron (200 mg), a β3-…
View article: Radiosynthesis of 20-[18F]fluoroarachidonic acid for PET-MR imaging: Biological evaluation in ApoE4-TR mice
Radiosynthesis of 20-[18F]fluoroarachidonic acid for PET-MR imaging: Biological evaluation in ApoE4-TR mice Open
View article: Exercise Capacity and Perceived Exertion on Treadmill Stress Test Performed While Wearing vs Without a Surgical Mask: A Randomized Clinical Trial in Healthy Adults
Exercise Capacity and Perceived Exertion on Treadmill Stress Test Performed While Wearing vs Without a Surgical Mask: A Randomized Clinical Trial in Healthy Adults Open
View article: A ketogenic intervention improves dorsal attention network functional and structural connectivity in mild cognitive impairment
A ketogenic intervention improves dorsal attention network functional and structural connectivity in mild cognitive impairment Open
Ketones, the brain's alternative fuel to glucose, bypass the brain glucose deficit and improve cognition in mild cognitive impairment (MCI). Our goal was to assess the impact of a 6-month ketogenic intervention on the functional connectivi…
View article: Quantitative SPECT (QSPECT) at high count rates with contemporary SPECT/CT systems
Quantitative SPECT (QSPECT) at high count rates with contemporary SPECT/CT systems Open
View article: The regional effect of serum hormone levels on cerebral blood flow in healthy nonpregnant women
The regional effect of serum hormone levels on cerebral blood flow in healthy nonpregnant women Open
Sex hormones estrogen (EST) and progesterone (PROG) have received increased attention for their important physiological action outside of reproduction. While studies have shown that EST and PROG have significant impacts on brain function, …
View article: The feasibility, reliability, and incremental value of two-dimensional speckle-tracking for the detection of significant coronary stenosis after treadmill stress echocardiography
The feasibility, reliability, and incremental value of two-dimensional speckle-tracking for the detection of significant coronary stenosis after treadmill stress echocardiography Open
View article: A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment
A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment Open
INTRODUCTION White matter (WM) energy supply is crucial for axonal function and myelin maintenance. Providing ketones, the brain’s alternative fuel to glucose, is a therapeutic strategy to bypass the brain’s glucose-specific energy deficit…
View article: A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment
A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment Open
Introduction White matter (WM) energy supply is crucial for axonal function and myelin maintenance. An exogenous source of ketones, the brain's alternative fuel to glucose, bypasses the brain's glucose‐specific energy deficit and improves …
View article: Selection of the optimal intensity normalization region for FDG-PET studies of normal aging and Alzheimer’s disease
Selection of the optimal intensity normalization region for FDG-PET studies of normal aging and Alzheimer’s disease Open
View article: Metabolism of Exogenous D-Beta-Hydroxybutyrate, an Energy Substrate Avidly Consumed by the Heart and Kidney
Metabolism of Exogenous D-Beta-Hydroxybutyrate, an Energy Substrate Avidly Consumed by the Heart and Kidney Open
There is growing interest in the metabolism of ketones owing to their reported benefits in neurological and more recently in cardiovascular and renal diseases. As an alternative to a very high fat ketogenic diet, ketones precursors for ora…
View article: A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment
A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment Open
Introduction Unlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides (kMCTs) could improve cognition in MCI by providing the brain wi…
View article: Links Between Metabolic and Structural Changes in the Brain of Cognitively Normal Older Adults: A 4-Year Longitudinal Follow-Up
Links Between Metabolic and Structural Changes in the Brain of Cognitively Normal Older Adults: A 4-Year Longitudinal Follow-Up Open
We aimed to longitudinally assess the relationship between changing brain energy metabolism (glucose and acetoacetate) and cognition during healthy aging. Participants aged 71 ± 5 year underwent cognitive evaluation and quantitative positr…
View article: [P3–317]: DHA BRAIN UPTAKE AND <i>APOE4</i> STATUS: A PET STUDY WITH [1‐<sup>11</sup>C]‐DHA
[P3–317]: DHA BRAIN UPTAKE AND <i>APOE4</i> STATUS: A PET STUDY WITH [1‐<sup>11</sup>C]‐DHA Open
The APOE ɛ4 (APOE4) allele is the strongest genetic risk factor identified for developing Alzheimer's disease (AD). Among brain lipids, alteration in the omega-3 (ω-3) polyunsaturated fatty acid docosahexaenoic acid (DHA) homeostasis is im…
View article: [IC‐P‐170]: STRATEGIES TO INCREASE BRAIN ENERGY SUPPLY IN MILD ALZHEIMER's DISEASE
[IC‐P‐170]: STRATEGIES TO INCREASE BRAIN ENERGY SUPPLY IN MILD ALZHEIMER's DISEASE Open
Alzheimer's disease (AD) is characterized by brain glucose hypometabolism. Fat-derived brain fuels such ketones (acetoacetate) have been proposed as an alternative fuel to compensate for the brain energy deficit widely observed in AD. We h…
View article: [P2–015]: STRATEGIES TO INCREASE BRAIN ENERGY SUPPLY IN MILD ALZHEIMER's DISEASE
[P2–015]: STRATEGIES TO INCREASE BRAIN ENERGY SUPPLY IN MILD ALZHEIMER's DISEASE Open
Alzheimer's disease (AD) is characterized by brain glucose hypometabolism. Fat-derived brain fuels such ketones (acetoacetate) have been proposed as an alternative fuel to compensate for the brain energy deficit widely observed in AD. We h…
View article: Treatment with enalapril and not diltiazem ameliorated progression of chronic kidney disease in rats, and normalized renal AT1 receptor expression as measured with PET imaging
Treatment with enalapril and not diltiazem ameliorated progression of chronic kidney disease in rats, and normalized renal AT1 receptor expression as measured with PET imaging Open
ACE inhibitors are considered first line of treatment in patients with many forms of chronic kidney disease (CKD). Other antihypertensives such as calcium channel blockers achieve similar therapeutic effectiveness in attenuating hypertensi…
View article: DHA brain uptake and APOE4 status: a PET study with [1-11C]-DHA
DHA brain uptake and APOE4 status: a PET study with [1-11C]-DHA Open