Étienne Larger
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View article: Decreased insulin dose-adjusted hemoglobin A1c in adults with cystic fibrosis-related diabetes treated with elexacaftor-tezacaftor-ivacaftor
Decreased insulin dose-adjusted hemoglobin A1c in adults with cystic fibrosis-related diabetes treated with elexacaftor-tezacaftor-ivacaftor Open
A numerically significant association between ETI and IDAA1c decrease was observed in adults with established CFRD after 24 months of treatment, suggesting ETI contributed to improved glycemic control.
View article: Beyond overweight, visceral adiposity is associated with estimation of cardiovascular risk in patients living with type 1 diabetes: findings from the SFDT1 cohort
Beyond overweight, visceral adiposity is associated with estimation of cardiovascular risk in patients living with type 1 diabetes: findings from the SFDT1 cohort Open
In PWT1D in condition of primary CV prevention, visceral adiposity, assessed by WHtR, is a more robust marker of estimated 10-year CV risk than overweight/obesity status in both men and women.
View article: Paediatric‐to‐adult transition in type 1 diabetes: A two‐centre experience of a structured program, 2014 to 2022
Paediatric‐to‐adult transition in type 1 diabetes: A two‐centre experience of a structured program, 2014 to 2022 Open
Background Transition from paediatric to adult healthcare is a turning point for patients with Type 1 diabetes (T1D). A gradual coordinated process connecting paediatric and adult healthcare providers may improve adherence to adult follow‐…
View article: Heterogeneity of glycaemic phenotypes in type 1 diabetes
Heterogeneity of glycaemic phenotypes in type 1 diabetes Open
Aims/hypothesis Our study aims to uncover glycaemic phenotype heterogeneity in type 1 diabetes. Methods In the Study of the French-speaking Society of Type 1 Diabetes (SFDT1), we characterised glycaemic heterogeneity thanks to a set of com…
View article: Validation of the Body Scan®, a new device to detect small fiber neuropathy by assessment of the sudomotor function: agreement with the Sudoscan®
Validation of the Body Scan®, a new device to detect small fiber neuropathy by assessment of the sudomotor function: agreement with the Sudoscan® Open
Background Sudomotor dysfunction is one of the earliest manifestations of small fiber neuropathy (SFN), reflecting the alteration of sympathetic C fiber innervation of the sweat glands. Among other techniques, such innervation can be asses…
View article: The Prognosis of Glutamic Acid Decarboxylase Antibodies in Women With Hyperglycemia in Pregnancy
The Prognosis of Glutamic Acid Decarboxylase Antibodies in Women With Hyperglycemia in Pregnancy Open
Context We recently reported that the presence of glutamic acid decarboxylase antibodies (GADA) was not associated with large-for-gestational-age infants in women with hyperglycemia in pregnancy (HIP). Objective We explored the association…
View article: The prognosis of glutamic acid decarboxylase antibodies in women with hyperglycemia in pregnancy
The prognosis of glutamic acid decarboxylase antibodies in women with hyperglycemia in pregnancy Open
Additional Figure 1: Flow chart Additional Table 1: Metabolic characteristics and adverse pregnancy outcomes in women with GADA measurement (study sample) or not (excluded from analyses) Additional Table 2: Metabolic characteristics accord…
View article: Protein supplementation changes gut microbial diversity and derived metabolites in subjects with type 2 diabetes
Protein supplementation changes gut microbial diversity and derived metabolites in subjects with type 2 diabetes Open
High-protein diets are promoted for individuals with type 2 diabetes (T2D). However, effects of dietary protein interventions on (gut-derived) metabolites in T2D remains understudied. We therefore performed a multi-center, randomized-contr…
View article: CT imaging shows specific pancreatic abnormalities in persons with cystic fibrosis related diabetes
CT imaging shows specific pancreatic abnormalities in persons with cystic fibrosis related diabetes Open
Cystic fibrosis related diabetes (CFRD) is observed in 20–50% of adults with cystic fibrosis (CF). Pancreas abnormalities on imaging, e.g. pancreas lipomatosis, are frequent in subjects with CF. We hypothesized that specific abnormalities …
View article: GAD Antibodies in Women With Hyperglycemia in Pregnancy: No Association With Large-for-Gestational-Age Birth Weight
GAD Antibodies in Women With Hyperglycemia in Pregnancy: No Association With Large-for-Gestational-Age Birth Weight Open
International audience
View article: High Prevalence of NASH and Advanced Fibrosis in Type 2 Diabetes: A Prospective Study of 330 Outpatients Undergoing Liver Biopsies for Elevated ALT, Using a Low Threshold
High Prevalence of NASH and Advanced Fibrosis in Type 2 Diabetes: A Prospective Study of 330 Outpatients Undergoing Liver Biopsies for Elevated ALT, Using a Low Threshold Open
OBJECTIVE Most people with type 2 diabetes (T2DM) and nonalcoholic steatohepatitis (NASH) or advanced fibrosis remain undiagnosed, resulting in missed opportunities for early intervention. This multicenter prospective study aimed at asse…
View article: High Prevalence of NASH and Advanced Fibrosis in Type 2 Diabetes: A Prospective Study of 330 Outpatients Undergoing Liver Biopsies for Elevated ALT, Using a Low Threshold
High Prevalence of NASH and Advanced Fibrosis in Type 2 Diabetes: A Prospective Study of 330 Outpatients Undergoing Liver Biopsies for Elevated ALT, Using a Low Threshold Open
OBJECTIVE Most people with type 2 diabetes (T2DM) and nonalcoholic steatohepatitis (NASH) or advanced fibrosis (AF) remain undiagnosed, resulting in missed opportunities for early intervention. This multicenter, prospective study assessed …
View article: High Prevalence of NASH and Advanced Fibrosis in Type 2 Diabetes: A Prospective Study of 330 Outpatients Undergoing Liver Biopsies for Elevated ALT, Using a Low Threshold
High Prevalence of NASH and Advanced Fibrosis in Type 2 Diabetes: A Prospective Study of 330 Outpatients Undergoing Liver Biopsies for Elevated ALT, Using a Low Threshold Open
OBJECTIVE Most people with type 2 diabetes (T2DM) and nonalcoholic steatohepatitis (NASH) or advanced fibrosis remain undiagnosed, resulting in missed opportunities for early intervention. This multicenter prospective study aimed at asse…
View article: Decreased steroidogenic enzyme activity in benign adrenocortical tumors is more pronounced in bilateral lesions as determined by steroid profiling in LC-MS/MS during ACTH stimulation test
Decreased steroidogenic enzyme activity in benign adrenocortical tumors is more pronounced in bilateral lesions as determined by steroid profiling in LC-MS/MS during ACTH stimulation test Open
Objective Large response of steroid precursors, including 17-hydroxyprogesterone, to adrenocorticotropic hormone (ACTH) has been described in adrenocortical tumors, suggesting the existence of intra-tumoral enzymatic deficiencies. This stu…
View article: HNF1B-MODY Masquerading as Type 1 Diabetes: A Pitfall in the Etiological Diagnosis of Diabetes
HNF1B-MODY Masquerading as Type 1 Diabetes: A Pitfall in the Etiological Diagnosis of Diabetes Open
Hepatocyte nuclear factor-1B (HNF1B) maturity-onset diabetes of the young (MODY), also referred to as “renal cysts and diabetes syndrome” or MODY-5, is a rare form of monogenic diabetes that is caused by a deletion or a point mutation in t…
View article: Performance of intermittently scanned continuous glucose monitoring systems in people with type 1 diabetes: A pooled analysis
Performance of intermittently scanned continuous glucose monitoring systems in people with type 1 diabetes: A pooled analysis Open
Aims To conduct a pooled analysis to assess the performance of intermittently scanned continuous glucose monitoring (isCGM) in association with the rate of change in sensor glucose in a cohort of children, adolescents, and adults with type…
View article: A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes
A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes Open
To circumvent the limitations of available preclinical models for the study of type 1 diabetes (T1D), we developed a new humanized model, the YES-RIP-hB7.1 mouse. This mouse is deficient of murine major histocompatibility complex class I a…
View article: Prospective external validation of a new non‐invasive test for the diagnosis of non‐alcoholic steatohepatitis in patients with type 2 diabetes
Prospective external validation of a new non‐invasive test for the diagnosis of non‐alcoholic steatohepatitis in patients with type 2 diabetes Open
Summary Background One of the unmet needs in patients with type 2 diabetes mellitus (T2DM) is the prediction of non‐alcoholic liver disease by non‐invasive blood tests, for each of the three main histological features, fibrosis, non‐alcoho…
View article: Response to Letter to the Editor from Woolcott and Castilla-Bancayán: “Diabetes Increases Severe COVID-19 Outcomes Primarily in Younger Adults”
Response to Letter to the Editor from Woolcott and Castilla-Bancayán: “Diabetes Increases Severe COVID-19 Outcomes Primarily in Younger Adults” Open
International audience
View article: Sex disparities in COVID-19 outcomes of inpatients with diabetes: insights from the CORONADO study
Sex disparities in COVID-19 outcomes of inpatients with diabetes: insights from the CORONADO study Open
Objective Male sex is one of the determinants of severe coronavirus diseas-e-2019 (COVID-19). We aimed to characterize sex differences in severe outcomes in adults with diabetes hospitalized for COVID-19. Methods We performed a sex-stratif…