Etsuko Sano
YOU?
Author Swipe
View article: MAPT-A152T mutation drives neuronal hyperactivity through Fyn-NMDAR signaling in human iPSC-Derived neurons: Insights into Alzheimer's pathogenesis
MAPT-A152T mutation drives neuronal hyperactivity through Fyn-NMDAR signaling in human iPSC-Derived neurons: Insights into Alzheimer's pathogenesis Open
These data demonstrate that the A152T mutation in the MAPT gene increases neuronal excitability through the tau-Fyn-NMDAR pathway in excitatory neurons, shedding light on its role in AD pathogenesis.
View article: Tau aggregation induces cell death in iPSC-derived neurons
Tau aggregation induces cell death in iPSC-derived neurons Open
Abnormal accumulation of tau proteins in the brain is observed in neurodegenerative diseases such as Alzheimer’s disease and is closely associated with neuronal cell death. However, the mechanism by which tau causes neuronal cell death rem…
View article: Controlling gene activation by enhancers through a drug-inducible topological insulator
Controlling gene activation by enhancers through a drug-inducible topological insulator Open
While regulation of gene-enhancer interaction is intensively studied, its application remains limited. Here, we reconstituted arrays of CTCF-binding sites and devised a synthetic topological insulator with tetO for chromatin-engineering (S…
View article: Author response: Controlling gene activation by enhancers through a drug-inducible topological insulator
Author response: Controlling gene activation by enhancers through a drug-inducible topological insulator Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract While regulation of gene-enhancer interact…
View article: Controlling gene activation by enhancers through a drug-inducible topological insulator
Controlling gene activation by enhancers through a drug-inducible topological insulator Open
While regulation of gene-enhancer interaction is better understood, its application remains limited. Here, we reconstituted arrays of CTCF binding sites and devised a s ynthetic t opological insulator with t etO for ch romatin-engineering …
View article: Control of directionality of chromatin folding for the inter- and intra-domain contacts at the Tfap2c–Bmp7 locus
Control of directionality of chromatin folding for the inter- and intra-domain contacts at the Tfap2c–Bmp7 locus Open
Our results show that the TZ not only separates the two domains, but also bears a wide interval that shows isotropic behavior of chromatin folding, indicating a potentially complex nature of actual boundaries in the genome. We also show th…
View article: MOESM2 of Control of directionality of chromatin folding for the inter- and intra-domain contacts at the Tfap2c–Bmp7 locus
MOESM2 of Control of directionality of chromatin folding for the inter- and intra-domain contacts at the Tfap2c–Bmp7 locus Open
Additional file 2. Table S1. List of ENCODE files of the CTCF binding peaks used in the study. Table S2. List of the CRISPR target sequences and their genomic coordinates, using the mm9 assembly. Table S3. Combination of CRISPR targets use…